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Mitigation of Obesity: A Phytotherapeutic Approach
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
A.B. Sharangi, Suddhasuchi Das
This plant is belongs to the Rutaceae family. Antiobesity effect of C. aurantium contains synephrine, a stimulant with comparable characteristics as caffeine and ephedrine. It is observed to have similar effects by increasing metabolism and energy expenditure and suppressing appetite (Haaz et al., 2006). C. aurantium aided in weight loss and increase thermogenesis to some extent. On the contrary, the loss of fat mass in the test group was appreciably superior compared to the placebo and control groups (Suryawanshi et al., 2011).
Drug Therapy for Obesity
Published in Ruth Chambers, Paula Stather, Tackling Obesity and Overweight Matters in Health and Social Care, 2022
Other potentially dangerous diet supplements can be bought online that might cause harm. Even if it is indicated that they should be bought directly from a pharmacist in the UK because of their medicinal properties, they can be readily purchased online from eBay, Wish.com and AliExpress, according to a recent Which? investigation.11 The investigators found that pills and powders containing yohimbine or synephrine were being promoted for weight loss that are extracted from herbs (from the bark of a tree and from bitter orange extract, retrospectively) and can inadvertently affect someone’s heart rate or blood pressure; these were easily bought from these online marketplaces.
Diseases of the Nervous System
Published in George Feuer, Felix A. de la Iglesia, Molecular Biochemistry of Human Disease, 2020
George Feuer, Felix A. de la Iglesia
Certain dietary factors appear to be associated with the onset of the attack in migraine patients; chocolate, cheese, or citrus fruits are most frequently quoted foodstuffs. Oranges are known to contain considerable amounts of octopamine and N-methyloctopamine or synephrine (Figure 9). Apart from tyramine, there may be other compounds related to migraine. Patients suffering from dietary migraine excrete significantly less free tyramine and far less conjugated tyramine than control subjects. It has been suggested that dietary factors may precipitate an inborn defect in the metabolism of tyramine and related factors.
Review of galectin-3 inhibitors in the treatment of nonalcoholic steatohepatitis
Published in Expert Review of Clinical Pharmacology, 2021
Atef Al Attar, Ani Antaramian, Mazen Noureddin
Gal-3 has been targeted by both natural and synthetic compounds. Synephrine is an active compound made from citrus tree leaves and is said to have anti-cancer properties. One study showed that targeting esophageal squamous carcinoma cells with synephrine can downregulate Gal-3, which inactivates the AKT and ERK pathways [57], but its precise action on Gal-3 is unknown. Additionally, RN1, a polysaccharide purified from the Panax flower, can also bind to Gal-3 and suppress the Gal-3-associated signaling pathway activity shown in pancreatic ductal adenocarcinoma cells [58]. Furthermore, modified heparin derivatives can abolish the Gal-3-mediated augmentation in lung metastasis of human melanoma and colon cancer cells by inhibiting Gal-3 ligand binding [59].
Review of Published Bitter Orange Extract and p-Synephrine Adverse Event Clinical Study Case Reports
Published in Journal of Dietary Supplements, 2020
Sidney J. Stohs, Sidhartha D. Ray
In this case study as in other case reports, the authors failed to review the literature, citing another case study and no current literature. The authors stated that “the patient’s condition could be attributed to his use of synephrine-containing weight loss and performance–enhancing supplements.” The authors further noted that mixing caffeine with synephrine can “lead to an increase in the adverse effects profile of each,” contrary to recent research (Unnikrishnan et al. 2018), while citing an article involving a product that contained ephedrine. No link or direct association with p-synephrine was demonstrated.