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Ethnobotany of the Silk Road – Georgia, the Cradle of Wine
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Rainer W. Bussmann, Narel Y. Paniagua Zambrana, Shalva Sikharulidze, Zaal Kikvidze, David Kikodze, David Tchelidze, Ketevan Batsatsashvili
Interesting local uses of medicinal plants include Botrychium lunaria L. and Sedum caucasisum Boris for the treatment of wounds, Daphne glomerata L. for toothache, Rhododendron caucasicum as a diuretic, and Rumex alpinus for intestinal problems and hemorrhoids. These applications are, however, by no means based on orally transmitted traditional knowledge; rather, they have been obtained from popular magazine clippings, or again, as local herbal remedies (Bussmann et al., 2016a,b, 2017a,b, 2018). Thus, overall, the Georgian herbal medicinal tradition, as it stands, is much less diverse than elsewhere in Central Asia, China, and the Himalayas (Figure 11.11).
Inhibiting Low-Density Lipoproteins Intimal Deposition and Preserving Nitric Oxide Function in the Vascular System
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Synonym: Sedum rosea (L.) Scop.Common names: hong jing tian (Chinese); rhodiolaSubclass Rosidae, Superorder Rosanae, Order Saxifragales, Family CrassulaceaeMedicinal use: tonic (China)
Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis
Published in Pharmaceutical Biology, 2023
Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang, Ling Shen
Emerging evidence has indicated that traditional Chinese medicine exhibited a therapeutic effect on PCOS (Xu et al. 2021; Ji et al. 2022). For example, salidroside is one of the important active ingredients of sedum rosea, which could inhibit dihydrotestosterone (DHT)-induced oxidative stress in KGN cells (Ji et al. 2022). In addition, Liuwei Dihuang Pills could effectively alleviate the symptoms of PCOS in rats by modulating the PI3K/Akt pathway (Qiu et al. 2020). Moreover, baicalin was able to attenuate hyperandrogenism in PCOS rats (Yu et al. 2019). In the current study, we found baicalin treatment significantly reduced the free testosterone, total testosterone, LH and FSH levels in rats with PCOS. In addition, baicalin was able to suppress the viability, proliferation and trigger the apoptosis of KGN cells. These studies suggested that traditional Chinese medicines could relieve the symptoms of PCOS in different ways. Meanwhile, baicalin might be regarded as a therapeutic agent for the treatment of PCOS (Yu et al. 2019; Fan et al. 2022).
Ameliorative effects of the traditional Chinese medicine formula Qing-Mai-Yin on arteriosclerosis obliterans in a rabbit model
Published in Pharmaceutical Biology, 2020
Lei Zhang, Jia-Qin Yuan, Fu-Chen Song, Mei-Dong Zhu, Qi Li, Sheng-Hua Liu, Kai Zhao, Cheng Zhao
Traditional Chinese medicines (TCMs) have been used for management of various diseases in China for thousands of years. As natural herbal medicines, TCMs are commonly safe for people to use for fighting against many of difficult miscellaneous diseases (Zhang Q et al. 2019; Du et al. 2020; Long et al. 2020). Qing-Mai-Yin (QMY) is a clinically used TCM formula for treating AS, ASO, and dyslipidemia, etc. (Wang et al. 2004), consists of the roots of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae), whole herb of Siegesbeckia orientalis L. (Compositae), tuber of Amorphophallus sinensis Belval (Araceae), roots of Rheum officinale L. (Polygonaceae), whole herb of Sedum sarmentosum Bunge (Crassulaceae), Laminaria japonica Aresch (Laminariaceae), Ostrea gigas Thunb. (Ostreidae), and Ramulus of Euonymus alatus (Thunb.) Sieb (Celastraceae). Based on cytotoxic test and electron microscope determination, previous research revealed that QMY has protective effect on TNF-α stimulated vascular endothelial cells (VECs) against cell death, cell apoptosis and cellular structure damage (Zhang et al. 2013; Qian and Zhao 2014). However, there is no systemic study on QMY regarding its chemical compositions and its curative activities on ASO animal model as well as the related potential mechanisms. Consequently, our present study investigates the effects of Qing-Mai-Yin (QMY) on an ASO rabbit model and its potential mechanisms.
Pharmaceuticals agents for preventing NSAID-induced gastric ulcers: a patent review
Published in Expert Review of Clinical Pharmacology, 2021
Daiane Franco Teixeira, Anamaria Mendonça Santos, Ana Maria Santos Oliveira, José Adão Carvalho Nascimento Júnior, Luiza Abrahão Frank, Marilia Trindade De Santana Souza, Enilton Aparecido Camargo, Mairim Russo Serafini
Another patent was founded by Oliveira (2018) when they produced polysaccharides from balsam leaves (Sedum dendroideum) to treat ethanol-induced gastric ulcers. The results showed a significant improvement in inflammatory parameters, gastroprotective activity, and immunomodulatory activity (BR 102,017,011,953–0 A2) [57].