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Phytopharmaceuticals in Cancer Treatment
Published in Prakash Srinivasan Timiri Shanmugam, Understanding Cancer Therapies, 2018
Prince Clarance, Paul Agastian
Sclerotiorin is an orange-yellow colored pigment belonging to the azaphilone class of pigments and was originally isolated from Penicillium sclerotiorum (Curtin and Reilly 1940). Today it is isolated from many other filamentous fungi. Recently Giridharan et al. (2012) reported that the endophytic fungi Cephalotheca faveolata from the healthy leaves of Eugenia jambolana Lam. are able to produce sclerotiorin (Giridharan et al. 2012).
Therapeutic potentials of endophytes for healthcare sustainability
Published in Egyptian Journal of Basic and Applied Sciences, 2021
Ayodeji O. Falade, Kayode E. Adewole, Temitope C. Ekundayo
Endophytes are also sources of the anticancer enzyme, asparaginase. Studies have shown that asparaginase from Colletotrichum sp. E5T9 effectively inhibited the survival rate of CaCo2 (colon adenocarcinoma) and HepG2 (hepatocyte carcinoma) cells [36,37]. However, beauvericin, a cyclic peptide purified from Fusarium sp. (No. DZ27) has been reported to inhibit KB and KBv200 cells growth by induction of ‘apoptosis’ via amelioration of oxidative stress, release of cytochrome c, upregulation of ‘caspase-9 and −3, cleavage of poly (ADP-ribose) polymerase (PARP)’ and failure of mitochondrial membrane potential [38]. Also, sclerotiorin obtained from Cephalotheca faveolate has been shown to stop the proliferation of colon cancer (HCT-116) cells through increased production of BAX, lowered production of BCL-2 and consequently, elevated the amount of cleaved caspase-3, which caused apoptosis of cancer cell lines [39].
Marine natural products as antifouling molecules – a mini-review (2014–2020)
Published in Biofouling, 2020
Ling-Li Liu, Chuan-Hai Wu, Pei-Yuan Qian
(+)-Sclerotiorin (53) was first isolated from the fungal strain Penicillium sclerotiorum (CHNSCLM-0013) by Maccurin and Reilly (1940). The chemical structure of 53 was characterized as a γ-lactone, a conjugated ketone, a chlorine atom at C-5 and a branched C-7 side chain. This compound inhibited settlement of cyprids of the barnacle A. amphitrite, with an EC50 value of 5.6 μg ml−1 (Wei et al. 2017). Eleven new and four known thielavins were isolated from an ethyl acetate (EtOAc) extract of the marine-derived fungal strain Thielavia sp. UST030930-004. Thielavins A (54), H (55), W–Y (56–58) and Z2–Z7 (59–64) were active against cyprid settlement of A. amphitrite, with EC50 values ranging from 1.2 to 36.3 μg ml−1 (Table 1). The inhibitory effect of compounds 56–58 and 60 was notably reversible (Han et al. 2017).