China
Africa
Explore chapters and articles related to this topic
Inflammatory Responses Acquired Following Environmental Exposures Are Involved in Pathogenesis of Musculoskeletal Pain
Published in Kohlstadt Ingrid, Cintron Kenneth, Metabolic Therapies in Orthopedics, Second Edition, 2018
Ritchie C. Shoemaker, James C. Ryan
Cortright discusses TRP channels and pain in 2009 [98]. TRP channel inhibitors block pain by blocking receptors where pain signals are generated. Xu published a report [99] on benefits of an antagonist of TRPV1 (called SB-366791) that dramatically reduced abdominal pain. Similarly, Zhu also published [100] on correction of pancreatic pain in animals by blockade of nerve growth factor. In these animals, density of TRPV1 on pancreatic sensory neurons was reduced.
Research progress of p38 as a new therapeutic target against morphine tolerance and the current status of therapy of morphine tolerance
Published in Journal of Drug Targeting, 2023
TRPV1 channels have been identified to play an important role in peripheral neuropathy and neuropathic pain [101,102] (Figure 2). In the state of pain, p38MAPK of the MPKA family is activated by inflammatory stimulation, which in turn activates TRPV1 to release neuropeptides and enhance the sensitivity to injury [102]. Recently, TRPV1 has become a new target for the treatment of morphine addiction and morphine tolerance [103]. Chronic morphine administration increases the expression of TRPV1 in the spinal dorsal horn and dorsal root ganglion neurons [104]. After the administration of TRPV1 antagonist SB-366791, the results of the thermal nociceptive behaviour test showed that SB-366791 decreased the release rate of substance P (SP) and calcitonin gene-related peptide (CGRP) and decreased morphine tolerance [105].
A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation
Published in Temperature, 2023
Dustin D. Luu, Aerial M. Owens, Mubark D. Mebrat, Wade D. Van Horn
A rat and mouse TRPV1 splice variant, TRPV1t, was reported to be involved in the amiloride-insensitive salt taste receptors in the chorda tympani [154,163–165]; albeit controversially [170–173]. TRPV1lt is reported to be heat-activated, and the addition of RTx, shifts the temperature activation curve to lower temperatures [154]. The TRPV1 antagonists, capsazepine and SB-366791, inhibited RTx, CAP, and heat activation and shifted the temperature curve to correspondingly higher temperatures [154]. Reverse transcription polymerase chain reaction (RT-PCR) revealed a 338 base pair band with 100% sequence identity to rTRPV1, rTRPV2, VR.5ʹsv, and SIC [154]. Based on the reported primer [154,174], the band is within the TMD region between S2-S5. However, it remains unclear if the reported responses are from TRPV1 or TRPV1lt because the sequence of the TRPV1t was not identified. It is still unclear how heat sensitivity of TRPV1t differs compared to that of the WT and further characterization is needed.