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COVID-19 Pandemic and Traditional Chinese Medicines
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Roheena Abdullah, Ayesha Toor, Hina Qaiser, Afshan Kaleem, Mehwish Iqtedar, Tehreema Iftikhar, Muhammad Riaz, Dou Deqiang
These granules are utilized in treatment of severe and short term upper respiratory tract infections because they possess characteristic broad spectrum anti-viral affect. The inhibiting activity of Shufeng jiedu capsules has proved to be effective against para-influenza virus, H1N1, respiratory syncytial virus (RSV), herpes simplex virus (HSV) type 1 and 2, adenivirus, coxsackievirus B4 and B5. The capsules constitute of Ban Lan Gen (radix isatidis), Bupleurum, Forsythia, Verbena, Rhizoma Phragmitis Communis (reed root), Glycyrrhiza glabra (licorice), Polygonum cuspidatum (Japanese knotweed) and Bupleurum falcatum (Chinese thoroughwax) that are effective for alleviation of inflammatory effects [21, 29].
Inflammatory Biomarkers: An Important Tool for Herbal Drug Discovery
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Mahfoozur Rahman, Ankit Sahoo, Mohammad Atif, Sarwar Beg
Resveratrol (RSV) is a polyphenolic compound that occurs naturally and is mostly derived from the skin of the grapes (Vitis vinifera). Various literatures have found thatthe root of polygonum cuspidatum is used as popular medicine in Japan and China, apart from grape skin. It includes enriched resveratrol. An effective action against arthritis is shown by the intra-articular injection of resveratrol by delaying in the IL-1, ROS, tumor protein (p53)-induced apoptosis, LTB-4, PGE2, and MPPs in animal models. Furthermore, it is also summarized in Table 1.1.
Chemopreventive Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
Resveratrol, also known as trans-3,5,4′-trihydroxystilbene (Figure 12.41), is a member of the phytoalexin family of compounds biosynthesized in plants during periods of environmental stress such as adverse weather conditions or attack by insects, animals, or pathogens. It has been found in more than 70 plant species, examples of which include peanuts, mulberries, red grapes, white hellebore, and fescue grass. Resveratrol is also a significant active ingredient in the powdered root of the Japanese knotweed (Polygonum cuspidatum), an Asian folk medicine known as “Kojo-Kon”. Structure of resveratrol (trans-3,5,4′-trihydroxystilbene).
Advances for pharmacological activities of Polygonum cuspidatum - A review
Published in Pharmaceutical Biology, 2023
Jia Ke, Meng-Ting Li, Shuyang Xu, Jianpeng Ma, Ming-Yuan Liu, Yan Han
Polygonum cuspidatum Sieb. et Zucc (Polygonaceae) is a traditional Chinese herb that grows in Asia and North America. The roots of Polygonum cuspidatum (PC) are listed in the Pharmacopoeia of the People’s Republic of China using the name of Huzhang. Resveratrol, polydatin, quercetin, emodin, and their derivatives are the primary active phytochemical components of PC. These phytochemical components of PC have undergone extensive research and are thought to be essential for PC’s medicinal functions (Lachowicz and Oszmiański 2019; Wang, Feng et al. 2019). Moreover, PC has been known to have anti-inflammatory (Liu et al. 2018), antioxidant (Zeng et al. 2019), antiviral (Lin et al. 2015), antimicrobial (Yang et al. 2015), neuroprotective effects (Liu et al. 2015), etc. It is seen as a potential treatment for arthritis, ulcerative colitis (Liu et al. 2018), asthma (Zeng et al. 2019), cardiac hypertrophy (Ding W et al. 2014), etc. The main objective of this review is to provide a systematic elaboration of the therapeutic effects of PC on a variety of diseases, so as to promote the understanding of PC and the development PC-derived herbal medicinal products and supplements.
The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver
Published in Drug and Chemical Toxicology, 2022
Azra Bozcaarmutlu, Canan Sapmaz, Ömer Bozdoğan, Aysel Kükner, Leyla Kılınç, Salih Tunç Kaya, Oğulcan Talat Özarslan, Didem Ekşioğlu
Resveratrol is a member of the polyphenol group found in plants. This compound is also classified as a phytoestrogen since it binds to estrogen receptor (Moutsatsou 2007). It is mostly found in the root of Polygonum cuspidatum, which is used in traditional medicine. It is also found in peanuts, black grapes, and red wine (Tomé-Carneiro et al. 2013, Al-Bishri 2017). The antioxidant, anti-cancer, and anti-inflammatory effects of resveratrol have been shown in several studies (Atten et al. 2001, El-Mowafy and Alkhalaf 2003, de la Lastra and Villegas 2007, Delmas et al. 2011). It has protective effects on the circulatory system and heart (Bertelli and Das 2009, Delmas et al. 2011). In diabetes, resveratrol has been shown to protect pancreatic beta cells, lower blood sugar and have a strong antioxidant effect (Szkudelska and Szkudelski 2010).
Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities
Published in Nutrition and Cancer, 2022
Mustafa B. A. Djamgoz, Valerie Jentzsch
This is a purgative resin from rhubarb (Polygonum cuspidatum), buckthorn and Japanese knotweed (Fallopia japonica) (Table 1B). By increasing activation of tumor suppressor genes via DNA demethylation, emodin suppressed PDAC cell proliferation (103–105). In combined treatments in vitro, emodin “sensitized” a drug-resistant cell line to gemcitabine (Figure 10A) (105). In an orthotopic xenograft model of PDAC, emodin promoted the effect of gemcitabine in suppressing tumorigenesis (Figure 10B) (106). The effects of emodin involved increased apoptosis and inhibited angiogenesis with possible transcriptional control via NF-κB (106–109). Finally, in a mouse model of PDAC, emodin dose-dependently decreased metastasis to liver by up to ca. 50% whilst “normalising” miR1271 expression and inhibiting EMT (107). In vitro and in vivo, liver cancer itself benefited from emodin treatment which also enhanced the effectiveness of a biological (sorafenib) therapy (110). Finally, also in an in vivo mouse model, cachexia could be reversed by long-term treatment with emodin and this occurred through decreased hypoxia inducible factor (HIF) - 1α signaling (111).