Pinane

Pinane

Biotransformation of Monoterpenoids by Microorganisms, Insects, and Mammals

Published in K. Hüsnü Can Başer, Gerhard Buchbauer, Handbook of Essential Oils, 2020

This results led us to study the biotransformation of (–)-pinane-2,3-diol (418ab′) and (+)-pinane-2,3 diol (418ab) by A. niger TBUYN-2. (–)-Pinane-2,3-diol (418ab′) was easily biotransformed to give (–)-pinane-2,3,5-triol (419ab′) and (+)-2,5-dihydroxy-3-pinanone (415a′) as the major products and (+)-2-hydroxy-3-pinanone (414a′) as the minor product.

Physiological and pathophysiological roles of hepoxilins and their analogs

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Published in Drug Metabolism Reviews, 2023

Sara A. Helal, Fadumo Ahmed Isse, Samar H. Gerges, Ayman O. S. El-Kadi

In agreement with these results, the effect of PBT-3 was compared to two thromboxane receptor antagonists SQ 29,548 and pinane thromboxane A2. The three compounds exhibited an antiplatelet effect in an ex vivo model but with different potencies. Interestingly, PBT-3 showed a high degree of specificity among other HxA3 and HX analogs when tested using a PFA-100-platelet function analyzer. It significantly prolonged the closure time in membranes coated with collagen/epinephrine in which platelet-related hemostasis is simulated (Reynaud et al. 2003). Albeit all four hepoxilin analogs (PBT-1 to PBT-4) can inhibit the aggregation of human platelet in vitro, it is obvious that PBT-3 is the most active with a 500-fold greater effect than the native HX (Reynaud et al. 2001). These results can make PBT-3 a worthy candidate for investigating new intervention strategies against diseases involving enhanced thromboxane production and platelet aggregation such as septic shock, thrombosis, and diabetes mellitus.

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Biotransformation of Monoterpenoids by Microorganisms, Insects, and Mammals

Physiological and pathophysiological roles of hepoxilins and their analogs