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Basic Principles in Photomedicine and Photochemistry
Published in Henry W. Lim, Nicholas A. Soter, Clinical Photomedicine, 2018
Skin is exposed daily to ultraviolet, visible, and infrared radiation from multiple sources including the sun, interior lighting, occupational light sources, and phototherapy systems. Photomedicine is concerned with the responses of tissue to these types of light as well as with the use of light for therapeutic purposes. Responses of skin to light are initiated by the absorption of ultraviolet and visible radiation by molecules in skin. Subsequently, the photoactivated molecules are converted into new compounds (photoproducts) that cause a series of biochemical changes in the tissue such as induction of enzyme activities, secretion of cytokines, and repair of damaged structures. After time, tissue changes can be observed by histologic examination and become apparent as lesions on the skin surface.
The Triple Heater (TH)
Published in Narda G. Robinson, Interactive Medical Acupuncture Anatomy, 2016
Tears, elongation, or strains of the dorsal radiocarpal ligament may negatively impact wrist stabilization and pronation. Laser therapy may aid in the restoration of ligamentous support on the dorsum of the wrist. It has shown value for problems associated with treatment of the transverse carpal ligament on the flexor surface.5 Photomedicine improves connective tissue health and provides analgesia.6
Ultraviolet-A1 and Visible Light Therapy
Published in Henry W. Lim, Herbert Hönigsmann, John L. M. Hawk, Photodermatology, 2007
Jean Krutmann, Akimichi Morita
Analysis of the mechanism of action of UVA-1 phototherapy has led to a rapid expansion of its indication spectrum. It is anticipated that this development will continue within the near future. In this regard, it has been of particular interest to learn that the generation of singlet oxygen by UVA-1 radiation represents a central photobiological mechanism required for the achievement of therapeutic effects (7). It is thus conceivable to assume that strategies directed at the amplification of singlet-oxygen-mediated effects as well as the development of alternative modes for singlet oxygen generation in human skin such as UV-free phototherapy will prove to be superior to UVA-1 phototherapy, as it is currently being employed. All these efforts will eventually contribute to the further development of UVA-1 and visible light phototherapy as one of the driving forces of modern photomedicine.
Malignant cell characterization via mathematical analysis of bio impedance and optical properties
Published in Electromagnetic Biology and Medicine, 2021
Lui et al. 2016 underscores the significance of refractive index in overhauling pivotal biophysical information about biological cell including determination of its cell metabolic activities. Liang et al. 2007, S. Carvalho 2016, Backman et al 2000 had all identified that rapid cell division in lesion cells account for higher refractive index and therefore is consequential for cell diagnosis. One of the primary advantages of optical frequency analysis is it allows scope for photomedicine application and targeted optimized drug delivery. However, more supporting in vitro research is pertinent to collect empirical data to prescient this technology in clinical application. The absorption property of malignant cell can also allow scope for targeted malignant cell destruction or chemotherapeutic treatment. As discussed earlier, the absorption property of malignant tissue commensurate with the nature of light–tissue interaction and is therefore a non-invasive or minimum invasive procedure. In future, peruse of absorption parameter is latent for precise cancer stage determination and in identification of the coordinate site of lesion cell.
Antiviral activity of curcumin-nanoemulsion associated with photodynamic therapy in vulvar cell lines transducing different variants of HPV-16
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Caroline Measso do Bonfim, Letícia Figueiredo Monteleoni, Marília de Freitas Calmon, Natália Maria Cândido, Paola Jocelan Scarin Provazzi, Vanesca de Souza Lino, Tatiana Rabachini, Laura Sichero, Luisa Lina Villa, Silvana Maria Quintana, Patrícia Pereira dos Santos Melli, Fernando Lucas Primo, Camila Fernanda Amantino, Antonio Claudio Tedesco, Enrique Boccardo, Paula Rahal
Nanoemulsions were synthesised by the “Photobiology and Photomedicine Group” at the Centre of Nanotechnology and Tissue Engineering of São Paulo University, in Ribeirão Preto, Brazil. Curcumin Nanoemulsions (NE-Cur) were prepared by curcumin solubilisation in oil phase followed by aqueous phase homogenisation with a hydrophilic emulsifier. The same procedure was used for empty nanoemulsion (NE), except the addition of curcumin. Further details on the formulation and preparation of nanoemulsions are in process of patent application and should be protected in accordance with the regulation of the Brazilian patent agency (Patent: Privilege of Innovation, Registration number: PI07063210).
Editors’ awardees for 2020
Published in International Journal of Hyperthermia, 2020
Currently, he is pursuing his post-doctoral training at the Wellman Center for Photomedicine, Massachusetts General hospital/Harvard University with Dr. Rox Anderson & Dr. Lilit Garibyan. He is presently studying the effect of novel injectable method of cryolipolysis for selective fat removal from deep tissues with the idea of improving treatment outcomes in metabolic diseases.