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Plant Species from the Atlantic Forest Biome and Their Bioactive Constituents
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Rebeca Previate Medina, Carolina Rabal Biasetto, Lidiane Gaspareto Felippe, Lilian Cherubin Correia, Marília Valli, Afif Felix Monteiro, Alberto José Cavalheiro, Ângela Regina Araújo, Ian Castro-Gamboa, Maysa Furlan, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva
Portuguese colonizers rapidly realized the potential of Brazilian flora as a source of novel interesting products as well as the valuable knowledge on plant species provided by native Indians, especially those associated to plant pigments and poisons. Chlorophora tinctoria (Moraceae) was known in the Indian language as “tatajuba”, which means firewood or fire-colored wood. The flavonol morin (6) was shown to be responsible for the color (Figure 9.1) and became soon became a major commodity exported to Europe to be used as a fabric pigment (Pinto, 1995).
Allergy and Asthma
Published in Hilary McClafferty, Integrative Pediatrics, 2017
Emerging research on morin, a naturally occurring flavonol found in high concentration in herbs in the Moraceae family, has shown it to have both anti-inflammatory and anticancer properties. Animal studies show promising activity against allergic airway inflammation by modulating the complex inflammatory response and reduction of total IgE levels. This and other work on naturally occurring anti-inflammatories will hopefully lead to an expanded range of effective and non-toxic options for asthma (Ma et al. 2016).
Therapeutic Medicinal Mushroom (Ganoderma Lucidum): A Review of Bioactive Compounds and their Applications
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Plant- and Marine-Based Phytochemicals for Human Health, 2018
Recently, Reis et al. (2015) reported induction of autophagy in human gastric adenocarcinoma cells by a methanolic extract of G. lucidum that was found to contains substantial amounts of phenolic compounds such as p-hydroxybenzoic acid (123 ± 9 μg/g extract), p-coumaric acid (80 ± 6 μg/g extract), and cinnamic acid (59 ± 6 μg/g extract). Autophagy is a “selfdigestive” process whereby, a cell is able to survive under nutrient (s) deprivation conditions. However, recent studies suggest that it may also be regarded as a cell death mechanism since the cells exposed to prolonged stress and continuous autophagy eventually “die off.” Although the methanolic extract induced autophagy, yet it was observed that the phenolics were not responsible for such an observation.111 The presence of phenolic compounds in G. lucidum namely protocatechuic acid, p-hydroxybenzoic acid, catechin, chlorogenic acid, vanillic acid, syringic acid, p-coumaric acid, rutin, and t-cinnamic acid was also confirmed by during the HPLC analysis of three mushrooms including G. lucidum. The study showed that G. lucidum had highest phenolic content, as well as individual phenolic compounds and also exhibited the highest antioxidant activity.181Saltarelli et al. (2015) performed a comparative analysis between G. lucidum extracts (Gl-4 and Gl-5) and G. resinaceum for their antioxidant and antiproliferative activities on U937 cells. The study demonstrated highest total phenol content in the Gl-4 isolate of G. lucidum and had highest antioxidant activity as measured by DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical scavenging activity and Fe+2 chelating activity. The major flavonoids detected included morin, myricetin, quercetin, and rutin.118
The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis
Published in Drug and Chemical Toxicology, 2022
Selçuk Özdemir, Sefa Kucukler, Selim Çomaklı, Fatih Mehmet Kandemir
In recent years, efforts to develop new anti-cancer drugs have been increasing due to the toxic effects of chemotherapeutic drugs used in cancer treatment (Butler et al.2014). Herbal plants have been used in the treatment of several diseases and cancer types because of the beneficial effects (Nafees et al.2018). The antioxidant compounds, such as flavonoids reduce the toxic effect of anticancer drugs in the cancer cells (Florea and Busselberg 2011). Flavonoids, categorized with flavones, flavonols, isoflavones, flavonols, flavanones, flavanonols, and chalcones are known as polyphenolic compounds (Kumar and Pandey 2013). Morin is a flavonoid and broadly found in white berry and cranberry branch (Campos-Esparza et al.2009, Cai et al.2018). It has been suggested that Morin reduces oxidative stress by inhibiting the production of ROS, prevents apoptosis by decreasing the release of apoptotic factors and increasing the Bcl-2 gene expression and antioxidant genes in rats (Kapoor and Kakkar 2012). Moreover, previous studies have been reported that Morin has several pharmacological benefits, including antioxidant, anti-inflammatory, anticancer, and anti-stress (Kandemir et al.2020, Çelik et al.2020). Given the beneficial pharmacological properties of Morin, it could be considered to reduce liver damage after IFOS usage. However, there is no data or report on beneficial effects of Morin against the IFOS toxicity in the liver.
Effect and underlying mechanism of morin on the pharmacokinetics of diclofenac sodium in rats
Published in Xenobiotica, 2021
Jinghua Zhang, Sennan Shao, Dan Huang, Jing Zhang, Yue Dai, Zhifeng Wei, Yufeng Xia
Morin (C15H10O7, Figure 1) is a natural flavonol, which is widely distributed in plants of the Moraceae family such as mulberry branches, mulberry leaves, and mulberry barks, as well as foods such as apples, guava, and honey (Aggarwal and Shishodia 2006; Lotito and Frei 2006; Wijeratne et al. 2006; Chen et al. 2018). Modern pharmacological studies have found that morin has a variety of beneficial pharmacological actions, including anti-inflammatory, immunomodulatory, anti-tumor and anti-oxidant, etc (Zeng et al. 2015; Sithara et al. 2017; Sultana et al. 2017; Wang N et al. 2018). Specifically, morin could significantly reduce inflammatory synovial angiogenesis and ameliorate histopathological changes of joints by inhibiting vascular endothelial growth factor induced migration and tube formation in human umbilical vein endothelial cells (Zeng et al. 2015). Furthermore, it was found that mannose decorated liposomal morin (ML-Morin) could target macrophages and osteoclasts in arthritis rats. The results demonstrated that ML-Morin preferentially reached macrophages and effectively inhibited inflammatory immune response and osteoclastogenesis, and its anti-inflammatory effect was superior to mannosylated liposomal dexamethasone palmitate, a reference drug proved by clinical and histological analysis (Sultana et al. 2017). Hence, morin is likely to be a promising drug candidate for the treatment of arthritis.
Morin inhibits colorectal tumor growth through inhibition of NF-κB signaling pathway
Published in Immunopharmacology and Immunotoxicology, 2019
Our results showed that Morin effectively suppressed the proliferation of cancer cells in two human colorectal cell lines, HT-29 and HCT-116 cells, both in a dose-dependent manner in vitro. Moreover, we found that Morin inhibited the growth of tumors derived from HCT-116 cells using a xenograft tumor model of human colorectal cancer. These results suggested that Morin could inhibit the proliferation of human colorectal cancer both in vitro and in vivo, which was consistent with previous findings. Recently, several studies have proposed that Morin inhibits cell proliferation in some other cell types. For instance, Perumal et al. [26] reported that Morin chemically inhibited stellate cell proliferation in vitro. Ke et al. [27] showed Morin inhibited cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition.