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Autoimmune Disease
Published in Gia Merlo, Kathy Berra, Lifestyle Nursing, 2023
Nanette Morales, Jessica Landry, Christy McDonald Lenahan, Janine Santora
Magnesium deficiency has been associated with pro-inflammatory states, increasing risk for AD development and exacerbation (Neilson, 2018). Magnesium deficiency results in increased intracellular calcium ions that promote pro-inflammatory cytokines (Nielson, 2018). Postmenopausal women have declining estrogen levels, which may cause neuroinflammation as a result of reduced intracellular neuronal magnesium (Zhang et al., 2021). Neuroinflammation can lead to magnesium deficiency in postmenopausal women and can lead to cognitive impairment, pain, and depressive symptoms. A study by Zhang et al. examined aged female mice and female mice without their ovaries with neuronal disorders, including depression-like behaviors, pain, and cognitive impairment (2021). The mice were given oral magnesium-L-threonate (L-TAMS). The study concluded that the oral administration of L-TAMS prevented or reversed cognitive impairment, pain, and depressive-like behaviors in both sets of mice. Magnesium supplements may be a treatment option for menopausal symptoms and reduce neuroinflammation.
Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake
Published in Nutritional Neuroscience, 2022
Bassem F. El-Khodor, Karma James, Qing Chang, Wei Zhang, Yvette R. Loiselle, Chinmayee Panda, Taleen Hanania
A recently developed Mg compound (magnesium-L-threonate, Mg threonate) significantly increased [Mg2+] in the brain when added to drinking water [2] or administered as a bolus gavage in adult rats [1]. This is a significant finding as Mg salts commonly used in dietary supplements have poor delivery of Mg2+ to the brain [1,2].