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Uro-Angiographic Contrast Agents—The Holy Grail
Published in Christoph de Haën, X-Ray Contrast Agent Technology, 2019
Despite the difficulties in many parts of the world iopamidol and/or iohexol, in one case even ioversol, are today offered on the market by companies without proper experience in contrast agent innovation, including Agfa HealthCare Imaging Agents GmbH, Cologne, Germany, iMax Diagnostic Imaging, subsidiary of Hovione FarmaCiencia SA, Loures, Portugal, Tae Joon Pharmaceutical Co. Ltd., Seoul, South Korea, Zhejiang Hisin Pharmaceutical Co. Ltd., Taizhou, China, SRS Pharmaceutical Pvd. Ltd., Mumbai, India and Teva Seiyaku K.K., Nagoya, Japan, Sanochemia Pharmazeutika AG, Vienna, Austria. They have to compete with the traditional innovators, which have invested heavily in manufacturing facilities and distribution channels located worldwide. The multitude of newly entering companies should not obscure the fact that so far, their market share has remained small.174 The principle competitors in the field, except for changes in ownership and some acquisitions of companies active in contrast agent related fields, have remained essentially the same few that had developed proprietary third-generation contrast agents. Their revenues allow continued investments in research and development of contrast agents, although mostly outside the field of X-rays.
Contrast media
Published in Debabrata Mukherjee, Eric R. Bates, Marco Roffi, Richard A. Lange, David J. Moliterno, Nadia M. Whitehead, Cardiovascular Catheterization and Intervention, 2017
Laura Davidson, Charles J. Davidson
LOCM are also available as nonionic monomers. These are tri-iodinated with many hydrophilic hydroxyl groups. They possess a 3:1 iodine-to-particle ratio and have an osmo- larity between 500 and 850 mOsm/kg. These include iopam- idol (Isovue), iohexol (Omnipaque), iopromide (Ultravist), ioxilan (Oxilan), and ioversol (Optiray). The nonionic LOCM cause less ventricular irritability than their ionic predecessors but generally have a slightly higher viscosity. Nevertheless, there is no increased risk of thrombotic events compared to ionic agents.3, 4 Additionally, nonionic LOCM are associated with less nephrotoxicity and fewer allergic reactions compared to HOCM.5
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor
Published in Drug Delivery, 2023
Hailing Tang, Changhui Cao, Guangyuan Zhang, Zhengkao Sun
We designed in this study a novel multivesicular liposomes (MVLs) embolization agent simultaneously encapsulating ioversol and doxorubicin. To achieve the embolic effect, the lipid formulations were adjusted to make the membrane more rigid and stable. Two different sizes of MVL preparations were made to investigate the embolic effect. Ioversol was loaded in MVL as a water-soluble contrast agent to present the precise position of MVLs in blood vessels under digital subtraction angiography (DSA). Cytotoxic drug doxorubicin was loaded together at low concentration but persistently for antiangiogenesis effect (Park et al., 2021). We evaluated the release profile of IVO-DOX-MVLs in vitro as well as their embolic effect when delivered intra-arterially into the VX2 liver tumor model in rabbits.
MiR-429 prohibited NF-κB signalling to alleviate contrast-induced acute kidney injury via targeting PDCD4
Published in Autoimmunity, 2021
Hui-Min Niu, Li-Qin Guo, Yan-Hong Qiao, Hai-Yan Jiao
NF-κB signalling is a well-known classical pathway in inflammatory response [34,35]. NF-κB signalling was also proved to be involved in cell apoptosis in many diseases including AKI [35]. Inhibition of NF-κB was proved to induce an attenuation of cisplatin-induced acute kidney injury [36]. Moreover, downregulation of TIMP metallopeptidase inhibitor 2 (TIMP2) was showed to lead inhibition of NF-κB pathway and thus ameliorated sepsis induced acute kidney injury [37]. However, the significance of NF-κB in CI-AKI was rarely studied. A previous study suggested that limb ischaemic preconditioning phosphorylated glycogen synthase kinase 3 beta (GSK-3β) and inhibited NF-κB to improve CI-AKI [38]. In the present study, we confirmed that NF-κB was involved in the induction of apoptosis in CI-AKI, which is consistent with this previous report. As concerned about the correlation of NF-κB signalling and PDCD4, PDCD4 was demonstrated to be an upstream regulator NF-κB signalling [39]. In the present study, we verified PDCD4/NF-κB signalling axis in CI-AKI, which might be a novel way of PDCD4 to induce apoptosis in CI-AKI. Moreover, it was reported that the most commonly used contrast media in clinic are iodine preparations, such as iodixanol [40], ioversol, [41] and iohexol [24], which can induce acute kidney injury. Based on previous studies [22,40,42], iodoxanol was more commonly applied to induce acute kidney injury, therefore, we chose the iodixanol for our experiments.
A Quantitative Study of the Dimensional Change of Inferior Vena Cava on Computed Tomography During Acute Hemorrhage Shock in Swine
Published in Journal of Investigative Surgery, 2020
Yang Li, Hai-feng Qi, Le-tian Zhang, Wei-guo Zhang, Lian-yang Zhang
The pigs were fixed in a pre-designed wooden frame in a supine position. All the CT scans were performed in a 64 Multi-slice Spiral CT scanner (LightSpeed 64 VCT, GE Medical System, Milwaukee, WI, USA) with contiguous 0.625-mm axial sections from 1st thoracic vertebra to pubic symphysis and then reconstructed with 5-mm section thickness. on-ionic contrast agent ioversol (1 ml/kg body weight, Hengrui Medicine, 350mgI/ml, China) was bolus injected (3.3 ∼ 5ml/s) through via automatic pressure injector (Ulrich syringes, Germany) from the right jugular vein.