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Biological Response Modifiers and Chemotherapeutic Agents that Alter Interleukin 2 Activities
Published in Ronald H. Goldfarb, Theresa L. Whiteside, Tumor Immunology and Cancer Therapy, 2020
William L. West, Allen R. Rhoads, Clement O. Akogyeram
Swainsonine, an indolizidine alkaloids, has generated interest in its potential use as an anticancer agent with reports that it: (i) inhibits tumor growth and metastasis (41), (ii) augments natural killer (NK) and macrophage-mediated tumor cell killing (42) and (iii) stimulates bone marrow cell proliferation (43). The antineoplastic activity of swainsonine can be explained, at least in part, by augmentation of immune effector mechanisms (44,45).
Biocatalyzed Synthesis of Antidiabetic Drugs
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019
Some examples of each kind are shown in Fig. 11.39: Thus, polyhydroxylated piperidine 1-deoxynojirimycin (DNJ) 108, isolated from the roots of mulberry trees, or pyrrolidine 2,5-dideoxy-2,5-imino-D-mannitol 109, commonly known as DMDP, found in many plants and microorganisms, have been both studied for their antihyperglycemic properties (Horne et al., 2011). Indolizidine 110 is the toxic alkaloid castanospermine, a potent inhibitor of lysosomal α-glucosidase (Lahiri et al., 2013). DNJ, DMDP and castanospermine also inhibit glycoprotein processing enzymes to varying degrees (Asano et al., 2000). Casuarine 111 is an example of a pyrrolizidine, which was also isolated from plants and have been used in the treatment of breast cancer, diabetes, and bacterial infections (Wardrop and Waidyarachchi, 2010). Finally, Calystegine A3112 belongs to nortropane-type alkaloids possessing glycosidase inhibitory activity (Asano et al., 2000).
Inhibitory activities of indolizine derivatives: a patent review
Published in Expert Opinion on Therapeutic Patents, 2020
Kamal M. Dawood, Ashraf A. Abbas
Indolizine (1) is a heteroaromatic ring that belongs to a class of bridgehead-N-fused heterocyclic systems. Indolizine is biostere for indole which is widely common in a large number of natural products, pharmaceuticals, and approved commercial drugs. Indolizine containing compounds have pronounced diverse biological properties and also employed in material science [123–4]. Hydrogenated indolizine (indolizidine) is a well-known core nucleus in many natural product alkaloids which are highly potent scaffolds for drug discovery [56789–10]. One of the most common bioactive indolizidine alkaloids is swainsonine (2) that had a potential chemotherapy drug [11] and toxicological properties [12131415–16] as well as therapeutic potentials [17181920–21]