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Nelumbo nucifera
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Pulok K. Mukherjee, Debayan Goswami, Bhaskar Das, Subhadip Banerjee
Extensive basic and clinical studies on higenamine (50) (a compound isolated from N. nucifera) showed valuable therapeutic effects on different disorders. Higenamine appears to be a useful pharmacological stress agent in myocardial perfusion imaging (MPI). A phase 2 trial was conducted to compare higenamine stress MPI with an adenosine stress test (Yanrong et al. 2014). Their study suggested that higenamine SPECT was comparable with adenosine SPECT at detecting areas of the heart with reduced blood flow. They also found a similar effect on the detection of left anterior descending coronary artery, left circumflex coronary artery and right coronary artery.
The stimulant higenamine in weight loss and sports supplements
Published in Clinical Toxicology, 2019
Pieter A. Cohen, John C. Travis, Peter H. J. Keizers, Frederick E. Boyer, Bastiaan J. Venhuis
Our study has several limitations. We purchased supplements at only one time point prior to WADA prohibiting higenamine in sport, and it is possible that the quantity of higenamine may vary over time [44] as manufacturers have unlimited flexibility to reformulate products. However, the number of supplements listing higenamine as an ingredient has not decreased since WADA’s 2017 prohibition of higenamine in sport, as of June, 2018 the National Institute of Health’s Dietary Supplement Label Database lists more than 30 brands of supplements labeled as containing higenamine [45]. Furthermore, we did not analyze the supplements for additional ingredients, and these ingredients, such as caffeine and yohimbine, might have important synergistic physiological effects [8]; therefore, the current study does not address the safety of any individual supplement product, but rather focuses on the presence and quantity of higenamine. Finally, we did not analyze supplements that did not list higenamine or a synonym on the label. As higenamine is a constituent of several botanicals, a variety of botanical supplements might contain higenamine without the stimulant being listed as an ingredient on the label.