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The Child with Fever or a Rash
Published in Miriam Orcutt, Clare Shortall, Sarah Walpole, Aula Abbara, Sylvia Garry, Rita Issa, Alimuddin Zumla, Ibrahim Abubakar, Handbook of Refugee Health, 2021
Neal Russell, Bhanu Williams, Anna Battersby
Consider topical or oral antibiotics with good hygiene measures. Topical options include fusidic acid (first line) and mupirocin (for MRSA). Treatment should be prescribed according to guidance, for example, fusidic acid applied three times a day for 7 days. Oral antibiotics should be given for infections that are extensive or resistant to topical treatment – for example flucloxacillin, clarithromycin or erythromycin. For recurrent infections, consider eradication of nasal carriage of staphylococcus aureus with chlorhexidine with neomycin or nasal mupirocin. Staphylococcal scalded skin syndrome requires inpatient secondary care with IV antibiotics. Children are considered infectious until all lesions are dry and scabbed over after 48 hours of antibiotics. Universal personal hygiene advice applies, and any toys should be washed in detergent and warm water.2
Monographs of Topical Drugs that Have Caused Contact Allergy/Allergic Contact Dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Fusidic acid is a bacteriostatic antibiotic derived from the fungus Fusidium coccineum that is used mostly as a topical medication to treat bacterial skin infections caused by Staphylococcus aureus, but is also given systemically as a tablet or injection. In pharmaceutical products, fusidic acid is employed as sodium fusidate (CAS number 751-94-0, EC number 212-030-3, molecular formula C31H47NaO6) (1).
High-Performance Liquid Chromatography
Published in Adorjan Aszalos, Modern Analysis of Antibiotics, 2020
Joel J. Kirschbaum, Adorjan Aszalos
Fusidic acid is an antibiotic with high antistaphylococcal activity. In the form of bulk material or as the sodium salt in pharmaceutical preparations, it was quantified using an octadecylsilane column and a mobile phase composed of 0.01 M KH2PO4, pH ≃6.6-methanol (3:1), flowing at 2 ml/min into a 254 nm detector [445]. Responses were linear between 50 and 1000 μg/1.
A review of antibiotics and psoriasis: induction, exacerbation, and amelioration
Published in Expert Review of Clinical Pharmacology, 2019
By binding on the elongation factor G (EF-G) and preventing EF-G turnover, fusidic acid inhibits bacterial protein synthesis. It mainly has effect on gram-positive cocci. Plaque psoriasis: previous promising and opposite reports [25–28] of fusidic acid in psoriasis treatment had led to a double-blind controlled trial (n = 20). Patients with recently overt or hidden infections were all excluded. The result showed no significant difference of clearing psoriasis in active treated group compared with placebo [29].
Antibiotic susceptibility of Staphylococcus aureus isolated from skin lesions in children. A retrospective analysis from a tertiary care Italian pediatric hospital
Published in Journal of Chemotherapy, 2021
Marilea Lezzi, Roberto Bandettini, Elisabetta Ugolotti, Carolina Saffioti, Alessio Mesini, Carlotta Pastorino, Francesca Manunza, Marta Ferretti, Giacomo Brisca, Elio Castagnola
The use of topical antibiotics has been associated with selection of resistant strains.10 In our study data on resistance to mupirocin could be poorly reliable because of the high proportion (70%) of untested strains. Fusidic acid showed a very low proportion of resistance (about 3%) but also in this case near 1/3 of strains were not tested. Finally, topical gentamycin is a highly used over the counter topical antibiotic in Italy, and indeed the resistance we observed was not negligible (9–12%). Our data suggest that fusidic acid could be the better topical choice, at least in our epidemiological condition.
Clostridium difficile infection in oncology patients: epidemiology, pathophysiology, risk factors, diagnosis, and treatment
Published in Hospital Practice, 2018
Omar Abughanimeh, Ayman Qasrawi, Osama Kaddourah, Laith Al Momani, Mouhanna Abu Ghanimeh
Other medications are also under investigation such as ridinilazole and LFF571. Both medications showed a similar clinical response to vancomycin in their phase 2 clinical trials [95]. Fusidic acid was listed in the IDSA/SHEA 2018 guidelines as a drug with ‘probable efficacy’, but it is not available in the United States [40].