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The Volatilome in Metabolomics
Published in Raquel Cumeras, Xavier Correig, Volatile organic compound analysis in biomedical diagnosis applications, 2018
Raquel Cumeras, Xavier Correig
Induced (exogenous) human volatiles are due to non-harmful external conditions. Those will include the resulting VOCs from the exposure to:drugs (Cumeras et al., 2013) – studied in pharmacometabolomics;environment (excluding pollutants) (Haitham et al., 2013);exposure to ionizing radiation (Menon et al., 2016) – studied in radiation metabolomics;microbials (excluding pathogens) (Petrof et al., 2013) – studied in microbiome; andnutrition (Gibney et al., 2005) – studied in foodomics.
Foodomics for human health: current status and perspectives
Published in Expert Review of Proteomics, 2018
Daniela Braconi, Giulia Bernardini, Lia Millucci, Annalisa Santucci
In the last decades, we have seen a progressive shift from nutrition research, traditionally focused on providing enough food to nourish people, toward an innovative view of diet as a way to improve or restore health [1]. The continuously growing interest on food-related topics including, but not limited to, safety, quality, traceability, genuineness, composition, sensorial profile, adulteration, contamination, and compliance with regulatory requirements, has prompted the scientific world toward the development and implementation of analytical techniques able to address these critical questions. In this framework, the term ‘foodomics’ was coined in 2009 by Cifuentes and collaborators to describe ‘a discipline that studies the Food and Nutrition domains through the application of advanced omics technologies to improve consumer’s well-being, health, and confidence’ [2–4]. Accordingly, foodomics is intended to be a global approach collecting and integrating information from several working areas where food (more generally, nutrition), advanced analytical techniques (omics, possibly coupled to in vitro, in vivo and clinical studies), and bioinformatics are all involved. Such a new discipline thus provides both impressive challenges and opportunities, since it is expected to improve our (so far) limited understanding of how food can promote health, prevent diseases, or increase individual performances. To this aim, it is necessary not only to identify potentially bioactive molecules, but also to understand the mechanisms through which such molecules induce changes at different levels (cell, tissue, and organ) and demonstrate their efficacy [1,5].