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Alginate and Hydrogel Applications for Wound Dressing
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Dina Fransiska, Ellya Sinurat, Fera Roswita Dewi, Hari Eko Irianto
Wound healing is a complex and ongoing process influenced by various factors, and it requires the right environment to recover quickly. Various wound dressings, such as fiber, sponge, hydrogel, foam, hydrocolloid, and others are used for wound treatment. Hydrogels are commonly employed in the biomedical industry because they may give mechanical support and a wet environment for wounds (Zhang & Zhao, 2020).
Innovations and Future Prospects of Dermal Delivery Systems
Published in Tapash K. Ghosh, Dermal Drug Delivery, 2020
Rashmi Upasani, Anushree Herwadkar, Neha Singh, Ajay K. Banga
Foams for dermal delivery offer remarkable advantages over traditional vehicles such as creams, gels, ointments, lotions and solutions. Ointments are composed of viscous, oily vehicles that are unpleasant to apply. Their tacky properties can result in patient discomfort and they can be difficult to remove from clothing. Similarly, creams and gels can leave a residue after application, which can stain clothing. Topically applied solutions may flow away readily from the site of application. The main attribute of foams is their exemplary cosmetic appeal. Foams, following expansion, can easily spread onto target areas, especially areas that are difficult to access such as behind the ear and neck. They are less sticky than cream formulations, easy to apply, leave fewer residues and hence are less likely to soil clothes and other parts of the body. They do not require rubbing during application and hence avoid the pain or irritation experienced during application of ointments, making them a dosage form of choice to treat highly inflamed skin conditions such as sunburn, eczema and psoriasis. Moreover, due to the evaporation of the propellant, they are likely to be cooler than ambient air, producing a cooling effect to the inflamed skin. Though there is no clinical evidence for foams to be superior to other formulations, their ease of application results in a high consumer appeal (Arzhavitina et al. 2010).
Surfactants in Cosmetic Products
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Ricardo Pedro, Kenneth A. Walters
Although the consumer usually associates foam with detergency, these terms are not synonymous because there are some efficient detergents that do not make too much foam. Foams have found many applications in the fields of firefighting, polymer insulation, rubber, concrete, ore extraction and topical pharmaceuticals, and have aesthetic utility in many personal care products and detergents, although their presence often does not contribute to the overall efficiency of the process. Foam is a psychological and functionally important factor with some surfactants, especially those used for the production of shampoos, skin cleansers, toothpastes and shave products.
Novel linezolid loaded bio-composite films as dressings for effective wound healing: experimental design, development, optimization, and antimicrobial activity
Published in Drug Delivery, 2022
Dina Saeed Ghataty, Reham Ibrahim Amer, Reham Wasfi, Rehab Nabil Shamma
Nowadays, a wide range of dressing materials including films, hydrogels, hydrocolloids, or foams are applied for diverse types of wounds and target various phases of the wound healing process. Dressing materials such as films are used to treat wounds and deliver therapeutic agents including, antibiotics and anti-inflammatory agents to the wound interface, to manage infection and pain (Colobatiu et al., 2019). Generally, films are biocompatible, biodegradable, and can be easily removed without trauma. They can be applied around different body parts exhibiting different shapes and contours, specifically around joints including knees, elbows, and hips owing to their mechanical properties. When applied over the wound, films promote wound healing by preventing the collection of exudates in the wound bed and maintaining a moist environment at the wound site to enhance tissue regeneration with minimum scar formation (Hafezi et al., 2019).
Application of nanotechnology in management and treatment of diabetic wounds
Published in Journal of Drug Targeting, 2022
Filipa Mascarenhas-Melo, Maria Beatriz S. Gonçalves, Diana Peixoto, Kiran D. Pawar, Victoria Bell, Vivek P. Chavda, Hajra Zafar, Faisal Raza, Ana Cláudia Paiva-Santos
Nanosystems have been described as modified drug delivery strategies over conventional systems, and viable solutions for the associated drawbacks of conventional drug delivery, by improved delivery patterns and related efficacy [15]. Conventional strategies such as skin substitutes, gene therapy, single or dual GF, cytokine stimulators and inhibitors, MMPs inhibitors have been used in the treatment of diabetic wounds. Current treatments usually include a suitable cleaning of the wound site and debridement, followed by the application of wound dressings, such as gauze, hydrogel, and foam [6, 16]. However, these materials need frequent change, cannot assure appropriate moisture and adherence to the wound site and most of the patients reveal pain on application or removal. Regarding GFs, their in vivo half-life time and absorption are low. Repeated application and fast elimination constitute other drawbacks, making it difficult to reach the wound bed. In addition, the application of these dressings does not fulfil the needs of each stage of the wound healing process. Thus, the development of a wound dressing that regulates skin modifications during each phase may be considered beneficial [6, 12, 16,17].
Therapeutic advances in wound healing
Published in Journal of Dermatological Treatment, 2022
André Oliveira, Sandra Simões, Andreia Ascenso, Catarina Pinto Reis
Although NPWT has been demonstrated to be effective in the treatment of numerous wounds as previously mentioned, there are some potential complications associated with its use. Therefore, clinicians should be aware of strategies to prevent them. There are three major complications, which can potentially be life-threatening, such as bleeding, infection, and retention of the foam dressing (147,149). The primary cause of bleeding is the mechanical damage of the underlying tissues and can be aggravated by infection, necrotic tissue or coagulopathy (149). Thereupon, it is not recommended NPWT’s foam dressing to be in direct contact with exposed blood vessels, organ, nerves, or anastomotic sites since the risk of fistulae formation in the presence of exposed organ or hemorrhage with exposed blood vessels is increased (147). Regarding the infections, the relation between infection and application of NPWT is not clearly defined although some authors have described chronic wound sepsis caused by retention of the foam dressing (150). Infections should be treated before NPWT application (147). Finally, retention of the foam in the wound may cause infection or bleeding since the dressing materials used with NPWT do not dissolve, and therefore, provoke an inflammatory reaction slowing the wound healing process down. Other complications include pain associated with dressing changes and patient’s allergy to the adhesive dressing or the foam material (in these cases, NPWT is not recommended) (147).