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Toxocara
Published in Dongyou Liu, Handbook of Foodborne Diseases, 2018
To prevent contamination of the environment by dogs, it is important to deworm adult pets (four times per year) and young puppies (at 2, 4, 6, and 8 weeks of age and then monthly until 6 months of age) with pyrantel, fenbendazole, or selamectine, which are effective against adult worms; to give prophylactic anthelmintics to newborn puppies, kittens, or pregnant bitches; to collect and dispose of pet feces immediately to prevent the eggs from becoming infective; and to control the stray dog population [50].
Microsporidians (Encephalitozoon cuniculi)
Published in Eric S. Loker, Bruce V. Hofkin, Parasitology, 2015
Eric S. Loker, Bruce V. Hofkin
Treatment Various benzimidazole-type drugs are suggested as treatments, including the anthelmintics albendazole, oxibendazole, and fenbendazole. Some studies suggest that there is enhanced efficacy when one of these drugs is administered in combination with enrofloxacin (Baytril®), a bacteriocidal drug commonly used in veterinary medicine.
Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes
Published in Xenobiotica, 2022
Young-Heun Jung, Dong-Cheol Lee, Jong Oh Kim, Ju-Hyun Kim
Fenbendazole (FBZ) [methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate] is a benzimidazole carbamate compound with broad-spectrum anthelmintic activity against pathogenic gastrointestinal nematodes, cestodes, and trematodes (Baeder et al. 1974; Dawson et al. 1984; Düwel 1977). Since the introduction of FBZ in the 1970s, the metabolism and pharmacokinetics of FBZ have been studied widely in various animals, such as trout, catfish, cattle, sheep, goats, donkeys, horses, pigs, and dogs (Campbell 1990; Gokbulut et al. 2006; Gottschall et al. 1990; Kitzman et al. 1990; Landuyt et al. 1993; McKellar et al. 2002; Sorensen and Hansen 1998; Virkel et al. 2004). Among the benzimidazole anthelmintics, FBZ has a wide range of efficacy and is also one of the most potent compounds against parasitic helminths (Lacey 1988). One of the most well-known marketed FBZ, Panacur®, is used routinely for treating roundworms, hookworms, whipworms, and taenia tapeworms in dogs (Ciuca et al. 2021; Itoh et al. 2009).
Oxfendazole: a promising agent for the treatment and control of helminth infections in humans
Published in Expert Review of Anti-infective Therapy, 2019
Armando E. Gonzalez, Ellen E. Codd, John Horton, Hector H. Garcia, Robert H. Gilman
Since fenbendazole as well as most BZs are metabolized by CYP enzymes, it is likely that OXF is similarly metabolized; presently, no data in this regard are in the public domain. Neither have there been any investigations of potential drug/drug interactions through analysis of CYP profiles. Also we are unaware of any data on whether any of the downstream metabolites of OXF have been investigated for activity. By analogy with other BZs, the degradation metabolites do not have any activity, e.g. albendazole sulphone. Interestingly, only ABZ and FBZ have active metabolites, albendazole sulphoxide and oxfendazole, respectively, and both are sulfur containing. Fenbendazole, a prodrug of OXF, has good activity against a number of animal nematodes that are close relatives of human infecting species.
Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes
Published in Archives of Physiology and Biochemistry, 2021
Oxfendazole (OFZ) is a member of the class of benzimidazoles that is fenbendazole in which the sulfur has been oxidised to the corresponding sulfoxide. It has a role as an antinematodal drug. It is a sulfoxide, a member of benzimidazoles and a carbamate ester. It is derived from fenbendazole (Ortiz et al.2014).