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Selected Functional Foods That Combat the Effects of Hyperglycemia and Chronic Inflammation
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
Some tea bags are treated with epichlorohydrin to prevent them from disintegrating or tearing. Epichlorohydrin is mainly used in the production of epoxy resins, and when it comes in contact with water, it breaks down to 3-MCPD, a known carcinogen that has also been linked to infertility and suppressed immune function. According to the Institute of Food Science and Technology (UK) Issues Statement on 3-MCPD, 25 March 2003, its presence in foodstuffs should be reduced to undetectable level (http://www.food navigator.com/Science/IFST-issues-statement-on-3-MCPD).
Nasal Cavity Carcinogens: Possible Routes of Metabolic Activation
Published in D. V. M. Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
Stephen S. Hecht, Andre Castonguay, Dietrich Hoffmann
Epichlorohydrin is a volatile liquid which is primarily used for production of synthetic glycerol and for epoxy resins. As a carcinogen it appears to act mainly at the site of application. In Swiss mice receiving 2 mg epichlorohydrin as a tumor initiator on skin and 2.5 μg tetradecanoyl phorbol acetate (TPA) thrice weekly as tumor promoter, 9 out of 30 animals developed papilloma of the skin during the 385-day experiment. In the control group treated only with TPA, 3 out of 30 mice developed skin papilloma.207 Upon weekly subcutaneous application of 1 mg of epichlorohydrin for up to 83 weeks, 6 out of 50 mice developed local sarcoma compared to only 1 sarcoma-bearing animal in a group of 50 mice receiving the solvent tricaprylin alone.207
Selected Functional Foods That Combat Inflammation
Published in Robert Fried, Lynn Nezin, Evidence-Based Proactive Nutrition to Slow Cellular Aging, 2017
Some tea bags are treated with epichlorohydrin to prevent them from disintegrating or tearing. Epichlorohydrin is mainly used in the production of epoxy resins and when it comes in contact with water, it breaks down to 3-MCPD, a known carcinogen that has also been linked to infertility and suppressed immune function. According to the Institute of Food Science and Technology (UK) Issues Statement on 3-MCPD, on 25 March 2003, its presence in food stuffs should be reduced to an undetectable level (http://www.foodnavigator.com/Science/IFST-issues-statement-on-3-MCPD).
Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Alessio Nocentini, Alessandro Bonardi, Simone Pratesi, Paola Gratteri, Carlo Dani, Claudiu T. Supuran
For instance, crosslinked chitosan (CS) resins have been proposed to achieve bilirubin caption because of their blood compatibility and antifungal activity78. In 2000, Yu et al. obtained and optimised crosslinked chitosan spherical beads by a crosslinking reaction of CS with glutaraldehyde (Figure 5)77. The resins were thus activated via epichlorohydrin and functionalised with varied polyamines (i.e. di-, tri-, tetra- and pentamines). Adsorption studies were carried on the protonated resin forms and evaluated the adsorption capability of BR in a phosphate buffer solution (pH 7.4). Most spherical beads produced an effective BR adsorption with both electrostatic interactions (between BR and the positively charged amine groups of the resin) and hydrophobic interactions (between BR and the polyamine hydrophobic spacers) being the driving force for the adsorption. The functionalised crosslinked CS resins showed higher adsorption capacity compared with simple crosslinked CS resin for both unconjugated and conjugated bilirubin. When evaluated with dog blood, the resins showed a good biocompatibility that gives crosslinked CS beads a certain advantage over activated charcoal and other polymeric adsorbents.
Weight of evidence analysis of the tumorigenic potential of 1,3-dichloropropene supports a threshold-based risk assessment
Published in Critical Reviews in Toxicology, 2020
Zhongyu (June) Yan, Michael Bartels, Bhaskar Gollapudi, Jeffrey Driver, Matthew Himmelstein, Sean Gehen, Daland Juberg, Ian van Wesenbeeck, Claire Terry, Reza Rasoulpour
There is an extensive body of literature on the in vitro and in vivo genotoxicity of 1,3-D. Many of these studies were previously reviewed by Stott et al. (2001). The focus of this article is on well conducted (i.e. guideline) in vivo studies using characterized test material not containing epichlorohydrin as these are the studies most relevant for assessing the potential human hazards related to exposure to 1,3-D. For 1,3-D, such studies have been uniformly negative (Table 2).
Zn2+-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Huibin Yu, Hongqin Ke, Tu Chen, Xing Li, Shenglong Tan, Lei Zhou, Shenqi Wang
Chitosan (89.4% deacetylated, MW: 702 kDa) was purchased from Aladdin Industrial Corporation (Shanghai, China). Diethylenetriamine and zinc sulfate heptahydrate were purchased from Sinopharm Chemical Reagent Co. Ltd (Shanghai, China). Epichlorohydrin was purchased from Lingfeng Chemical Reagent Co. Ltd (Shanghai, China). All other reagents are analytical grade.