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Psychopharmacology EMIs
Published in Michael Reilly, Bangaru Raju, Extended Matching Items for the MRCPsych Part 1, 2018
Each option may be used once, more than once or not at all.For each of the following statements about adverse effects of antipsychotics, choose the drug above that is most likely to be implicated.A common side-effect of this thienobenzodiazepine atypical antipsychotic is weight gain.This dibenzothiazepine atypical antipsychotic is not associated with any significant increase in serum prolactin levels.This substituted benzamide antipsychotic is thought to have a dose-dependant action at presynaptic dopamine sites.This diphenylbutylpiperidine is the longest-acting per oral administered antipsychotic.
100 MCQs from Dr. Guy Molyneaux and Colleagues
Published in David Browne, Selena Morgan Pillay, Guy Molyneaux, Brenda Wright, Bangaru Raju, Ijaz Hussein, Mohamed Ali Ahmed, Michael Reilly, MCQs for the New MRCPsych Paper A, 2017
Dr Pauline Devitt, Dr Angela Noonan, Dr Klaus Oliver Schubert, Prof Finian O’Brien
Fluspirilene is a diphenylbutylpiperidine with a long half-life and is administered as a particle suspension. In contrast, flupenthixol, fluphenazine, clopenthixol and haloperidol are all prepared as ester decanoates. (5, p 390)
ENTRIES A–Z
Published in Philip Winn, Dictionary of Biological Psychology, 2003
The antipsychotic drugs are those given to combat PSYCHOSIS, but in general it is taken as read that by antipsychotic one is referring to a drug given to treat the SIGNS AND SYMPTOMS of SCHIZOPHRENIA. The terms MAJOR TRANQUILLIZER and NEUROLEPTIC are to all intents and purposes synonymous with the term antipsychotic: antipsychotic is used for preference. The first antipsychotic to be given was CHLORPROMAZINE. In the 1940s Henri Laborit (1914-1995), a French surgeon, administered this to patients about to undergo surgery, in order to reduce STRESS. He hypothesized that the drug's calming effect could have benefit in treating schizophrenic patients. It was tested for this property and found to be very successful. Other members of the class of drugs—the PHENOTHIAZINES—to which chlorpropmazine belongs were also found to have antipsychotic properties. From a class of drugs related to the phenothiazines, the THIOXANTHINES, were derived the BUTYROPHENONES. Included in this group are HALOPERIDOL and SPIROPERIDOL. The phenothiazines and butyrophenones are commonly used to treat schizophrenia. There are also the so- called ATYPICALANTIPSYCHOTIC drugs (or ATYPICAL NEUROLEPTICS) which are members of other classes: for example, SULPIRIDE (a benzamine), MOLINDONE (similar to SEROTONIN) and PIMOZIDE (a diphenylbutylpiperidine). CLOZAPINE has also been used as an antipsychotic. Antipsychotic drugs are generally characterized as being antagonists at DOPAMINE receptors (see ANTAGONIST). Studies have shown striking correlations between the ability of a drug to bind to dopamine receptors (particularly D2 dopamine receptors) and antipsychotic potency. This relationship has been very influential in generating the DOPAMINE HYPOTHESIS OF SCHIZOPHRENIA. However, clozapine is a marked exception to this general rule. Although it has an antagonistic effect at dopamine receptors, it also has a variety of other properties. Despite this lack of specificity it is a widely used antipsychotic, with more power to combat the negative symptoms of schizophrenia that the phenothiazines or butyrophenones. It does have other unwanted effects that limit its use.
Repurposing antipsychotic drugs for cancer treatment: current evidence and future perspectives
Published in Expert Review of Anticancer Therapy, 2022
Georgios D. Lianos, George A. Alexiou, Stefano Rausei, Vasiliki Galani, Michail Mitsis, Athanasios P. Kyritsis
Pimozide belongs to the diphenylbutylpiperidine class of antipsychotic drugs and has shown anti-cancer effects for melanoma and neuroblastoma via proposed anti-dominographic effects. This drug was also found to sensitize tumor cells to radiation and inhibited STAT-3 and STAT-5 signaling proteins, thus had potential activity in leukemia and prostate cancer [18].