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Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Astragalus membranaceus contains many types of phytochemicals including: formononetin, astraisoflavan, astrapterocarpan, 2’-3’-dihydroxy-7,4’-dimethooxyisoflavone, isoliquiritigenin, D-ß-asparagine, calycosin, cycloastragenol, astragalosides, kumatakenin, ß-sitosterol, soyasaponin, and astragalin.2 Extracts of Astragalus membranaceus exhibit a variety of pharmacological effects of significance for the treatment of MDD.
Anti-Aging and Regenerative Medicine
Published in Aruna Bakhru, Nutrition and Integrative Medicine, 2018
Astragalus is a traditional Chinese medicinal herb which improves the functioning of the immune system and boosts immune therapy for cancer (Programmed-aging 2015). Cycloastragenol is a compound obtained from astragalus and plays an important role in the activation of telomeres. It helps to kill cancer cells, heal burns and protects from heart disease. The researchers of the University of Texas, Anderson Cancer Center reported that astragalus improved the immune system. Patients having breast cancer showed a decline in mortality rate from 50% to 10%, when administered as a combination of astragalus with other compounds. The group of patients who received pure astragalus extracts showed double the chances of survival (Gupta, Pulapalli, and Srikanth 2015).
Immunosenescence, inflammaging, and cancer immunotherapy efficacy
Published in Expert Review of Anticancer Therapy, 2022
Julieta E Rodriguez, Marie Naigeon, Vincent Goldschmidt, Matthieu Roulleaux Dugage, Lauren Seknazi, Francois X Danlos, Stephane Champiat, Aurélien Marabelle, Jean-Marie Michot, Christophe Massard, Benjamin Besse, Roberto Ferrara, Nathalie Chaput, Capucine Baldini
Functionally, senescent T cells are highly cytotoxic and glycolytic, partly due to down-regulation of the SIRT1-FOXO1 axis. SIRT1 is a deacetylase protein involved in metabolic processes that expression decreases with age. Boosting the SIRT1-FOXO1 axis in vitro with resveratrol or nicotinamide riboside induces a metabolic shift of CD28− CD8+ T cells to the one of naive and memory CD28+ T cells, providing a potential therapeutic strategy for reprogramming senescent T cells [81]. Rejuvenating senescent T cells by telomeres elongation could also be an option, and cycloastragenol has been shown to delay telomere shortening and increase telomerase activity and proliferative capacity in CD8+ cells. However, without specific targeting of senescent cells, telomere lengthening strategies can be unsafe in a cancer setting [82].
Comparison of the inhibition potential of parthenolide and micheliolide on various UDP-glucuronosyltransferase isoforms
Published in Xenobiotica, 2019
Wei-Feng Gao, Yi-Xuan Li, Wei-Hua Zhang, Ran Tao, Ting-Ting Yin, Yi-Jia Wang, Li-Na Liu, Zhi-Wei Fu, Sai-Nan Li, Nai-Rong Liu, Heng Zhang, Guang Liu, Li-Zhong Zhao, Xi-Peng Zhang, Chun-Ze Zhang
Many previous literatures have reported the inhibitors of UGT isoforms from herbs. For example, herbal components Atractylenolide I and III showed the inhibition toward the activity of UGT2B7 (Zhang et al., 2016). Herbal component cycloastragenol exerts inhibition on the activity of UGT1A8 and UGT2B7 (Li et al., 2012; Mohamed & Frye 2011; Ran et al., 2016).