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Role of Medicinal Plants in the Treatment of Hemorrhoids
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Yaw Duah Boakye, Daniel Obeng Mensah, Eugene Kusi Agyei, Richard Agyen, Christian Agyare
The major phytochemicals in Cissus quadrangularis are flavonoids. Bioflavonoids have been shown to exhibit phelotonic, vasculoprotective, and anti-inflammatory activities. Luteolin and ß-sitosterol from the crude extract of C. quadrangularis have been shown to produce its anti-inflammatorry effect. The venotonic effect of C. quadrangularis has been postulated to be due to the flavonoids present in its crude extract, which act in the same way as that of diosmin and hesperidin (found in Daflon).53
Perspectives of Nature-Oriented Pharmacotherapeutics for the Effectual Management of Hemorrhoidal Symptoms
Published in Debarshi Kar Mahapatra, Cristóbal Noé Aguilar, A. K. Haghi, Applied Pharmaceutical Practice and Nutraceuticals, 2021
Taranpreet Kaur Bamrah, Mojabir Hussen Ansari, Debarshi Kar Mahapatra
Cissus quadrangularis is commonly found in Asia and Africa and is useful particularly in the relief of bleeding hemorrhoids. The plant is extremely useful in treating pain (by selectively inhibiting the local mediators and nociceptors in the central nervous system) and inflammation (reduction in the release and synthesis of related mediators, principally prostaglandins). On longer application, it is perceived that the magnitude of hemorrhoids condenses and prevents bleeding.
Unbiased research
Published in C. P. Khare, Evidence-based Ayurveda, 2019
15 Evaluation of the hepatoprotective activity of Cissus quadrangularis stem extract against isoniazid-induced liver damage in rats: Viswanatha Swamy AH, RV Kulkarni, AH Thippeswamy, BC Koti, A Gore, Indian Journal of Pharmacology, 2010, 42: 397–400.
Cissus quadrangularis extract mitigates diabetic cardiomyopathy by inhibiting RAAS activation, inflammation and oxidative stress
Published in Biomarkers, 2022
Anees Ahmed Syed, Mohammad Irshad Reza, Mohammad Shafiq, Sanjana Kumariya, Roshan Katekar, Kashif Hanif, Jiaur R. Gayen
Cissus quadrangularis (family: Vitaceae) is a perennial medicinal plant present worldwide, including in Thailand, South Africa, the Philippines, Sri Lanka and India. In traditional Indian medicinal systems, nearly the whole plant is used to treat various diseases (Mehta et al.2001). It is also used as a foodstuff (Enechi and Odonwodo 2003), has nutritive (Malathi 2014), and has application in nutraceutical food products (Karadbhajne et al.2014). This plant provides a source of dietary supplements such as carbohydrates, lipids, protein and fibres. It also includes ash (Kumar 2018). It is rich in phenolic compounds, β-carotene and Vit. C (Enechi and Odonwodo 2003, Singh et al.2007, Malathi 2014). The plant stem possesses incredibly good nutritional and therapeutic properties. It promotes the health of the bones (Lakshmanan et al.2020) and is also used in nutraceutical products (bakery products) (Karadbhajne et al.2014). It also contains flavonoids, iridoids, stilbenes, β-sitosterol, and β-sitosterol glycoside (Singh et al.2007), phenolic glycoside, lignan glycosides (Kumar et al.2019). C. quadrangularis is used for the treatment of back and neck problems (Asolkar and Chopra 1992), osteoporosis (Kumar et al.2010), asthma, haemorrhoids, muscular and joint pains, and menstrual disorders (Mehta et al.2001). Recent studies have shown the EECQ ameliorates insulin resistance in peri-/post-menopausal rats (Syed et al.2022b) and hypertension in genetically hypertensive rats (Syed et al. 2022a).
Ethanolic extract of Cissus quadrangularis improves vasoreactivity by modulation of eNOS expression and oxidative stress in spontaneously hypertensive rats
Published in Clinical and Experimental Hypertension, 2022
Anees Ahmed Syed, Mohammed Shafiq, Mohammad Irshad Reza, Pragya Bharati, Athar Husain, Pragati Singh, Kashif Hanif, Jiaur R. Gayen
A medicinal plant Cissus quadrangularis is often used throughout the world to cure bone fractures; thus, commonly known as Hadjod. This plant is widely found in Srilanka, West Africa, Malaysia, and India (27). C. quadrangularis is commonly used to treat fracture repair, menstrual disorder, and smooth muscle relaxation activity (28). Traditionally, several Cissus species plants are being used for diabetes treatment (29). Besides, C. quadrangularis has both hypoglycemic and free radical scavenging activities (30,31). Phytochemical screening revealed flavonoids, phytosterols, triterpenoids, and anabolic steroids in C. quadrangularis (32). Till date, no studies have been conducted to explore the antihypertensive and vasorelaxant activities of this plant. Therefore, in this research, we have explored the antihypertensive efficacy of C. quadrangularis using conscious SHR as well as the mechanism of its vasorelaxant function using isolated aortic SHR rings.
Green synthesis of copper nanoparticles using Cissus vitiginea and its antioxidant and antibacterial activity against urinary tract infection pathogens
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Shuang Wu, Shanmugam Rajeshkumar, Malini Madasamy, Vanaja Mahendran
Cissus vitiginea belongs to the family Vitaceae consists of about 14 genera and 900 species primarily distributed in tropical regions [20]. It is a common medicinal value perennial climber and is distributed throughout India, particularly in tropical regions. It has a rich number of antioxidants [21]. Antioxidants may be for great benefit in improving the quality of life by preventing or postponing the onset of degenerative diseases [22]. This plant was used in Ayurveda as an alternative, dyspeptic, digestive, tonic analgesic in the eye and ear diseases and the treatment of irregular menstruation and asthma [23]. This present study was attempted to find out the antibacterial and antioxidant activity of green synthesized nano copper by using C. vitiginea leaf extract as a reducing agent against the urinary tract pathogens and 2,2-diphenylpicrylhydrazyl (DPPH) free radical.