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Wearable Sensors for Blood Perfusion Monitoring in Patients with Diabetes Mellitus
Published in Andrey V. Dunaev, Valery V. Tuchin, Biomedical Photonics for Diabetes Research, 2023
Evgenii A. Zherebtsov, Elena V. Zharkikh, Yulia I. Loktionova, Angelina I. Zherebtsova, Viktor V. Sidorov, Alexander I. Krupatkin, Andrey V. Dunaev
The index of microcirculation (Im) was recorded for 10 minutes in the supine position. To assess the state of the microcirculatory system and obtain quantified diagnostic information, the bypass index (BI), nutritional, and shunt blood flow parameters were evaluated [57]. The total value of the BI was obtained by adding two components: BI1 – the shunting index associated with differences in tone in the microvessels of the nutritive and non-nutritive blood flow pathways directly within the microcirculatory bed; BI2 – the shunting index associated with differences in perfusion of microvessels and larger vascular segments (arteries, venules, and veins) in cases of arterial hyperemia or venous stagnation [58]. For zones with AVA (e.g., big toes) and without AVA (e.g., shins), BI1 was calculated using formulas 5.3 and 5.4, respectively:
3-Dimensional nano-fibre scaffold for ex vivo expansion of cord blood haematopoietic stem cells
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Seyed Hadi Mousavi, Saeid Abroun, Masoud Soleimani, Seyed Javad Mowla
The importance of HOXB-4, BIM-1, HOX-A9 and hTERT in HSC self-renewal has been demonstrated before [23]. Some study shows that increased expression of Bmi-1 and HOXB-4 led to the symmetrical cell division of HSC and results in HSC expansion [39,40]. Also, other studies showed ectopic expression of HOXB-4 can mediate a significant expansion of HSC [41,42] and also HOXB-4 and HOXA-9, enhance HSC activity. Human telomerase reverse transcriptase (hTERT), in human CB CD34+ cells lead to an enhanced survival of mature haematopoietic cells. Our results confirm this study and showed that after expansion, especially in 3D PCL nano-scaffold increased self-renewality genes.
Cytoplasmic p27 is a novel prognostic biomarker and oncogenic protein for nasopharyngeal carcinoma
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Yaoshu Teng, Linping Hu, Bo Yu, Xiao Li, Manman Chen, Xiao Fu, Jin Zhang, Yueqiu Gao, Rujun Xu, Jin Zhu
As tumour-promoting genes, Bim-1 and Twist1 are involved in the proliferation and invasion of human tumour cells and are both highly expressed in NPC cell lines and NPC tissues. Overexpression of Bim-1 or Twist1 is negatively correlated with the prognosis of patients with NPC, suggesting that Bim-1 and Twist1 play oncogenic roles in NPC development [12,13]. However, whether cytoplasmic p27 participates in the proliferation, migration and invasion processes of NPC cells by regulating the expression of Bim-1 or Twist1 in NPC cells remains unclear.
Effectiveness of physiotherapy in elderly patients with dementia: a prospective, comparative analysis
Published in Disability and Rehabilitation, 2019
Joanna Kowalska, Justyna Mazurek, Natalia Kubasik, Joanna Rymaszewska
The above studies were conducted at two testing points: upon admission to the ward (T1: BI0, MMSE0) and after 3 months of regular physiotherapy (T3: BI3, MMSE3). Additionally, the patients’ functional status was assessed monthly (BI1, BI2). Physiotherapy efficacy was calculated as the difference between functional status at the time of admission to the ward (BI0) and functional status after physiotherapy (BI3; PE = BI3 − BI0).