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Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Decursin (Figure 4.10) isolated from the arial part of Angelica gigas (Miq.) Franch. & Sav. inhibited at a concentration of 20 μg/mL by approximately 40% the accumulation of triglycerides during the differentiation of 3T3-L1 preadipocytes (induced by insulin-dexamethasone-3-isobutyl-1-methylxanthine) in vitro and lowered the expression of fatty acid synthetase.206 When the differentiation of preadipocytes into adipocytes is induced experimentally in vitro by insulin, dexamethasone, and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, the expression of positive regulators of adipogenesis is increased.207 Once such regulator is sterol regulatory element-binding protein-1c with induces the expression of fatty acyl synthetase which catalyzes the synthesis of fatty acids. Decursin given at a daily dose of 200 mg/kg to C57BL/6J mice as part of high-fat diet for 7 weeks lowered body weight gain despite unchanged food intake.206 This prenylated coumarin brought serum triglycerides from 112 mg/dL to 87.3 mg/dL (normal: 97.2 mg/dL), and lowered total cholesterol from 253.6 to 216.3 mg/dL (normal: 230.3 mg/dL).206 This regimen improved glucose tolerance in parenteral glucose administration. This prenylated coumarin lowered the production of leptin, resistin, interleukin-6, and monocyte chemoattractant protein-1 induced by high-fat diet.206 Leptin, resistin, interleukin-6, and monocyte chemoattractant protein-1 are negatively regulated by peroxisome proliferator-activated receptor-γ suggesting that decursin and/or first-pass metabolite(s) could act as peroxisome proliferator-activated receptor-γ agonist.
Angelica gigas root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways
Published in Pharmaceutical Biology, 2021
Se-Eun Lee, Chiyeon Lim, Suin Cho
Angelica gigas is a medicinal plant that is widely used in traditional Korean medicine, but not in Chinese medicine. This study confirmed that pre- and post-treatment with AGR, which is used in Korean medicine, exerts a neuroprotective effect in an ischaemia-induced brain infarction mouse model; in addition, some of the mechanisms involved in this effect were investigated. However, the treatment had no effect on changes in NDS. The reason may be the short behaviour observation period in our study. Thus, we plan to investigate whether NDS can improve with longer behaviour observation period, in our future study.
Exploring the potential of solid dispersion for improving solubility, dissolution & bioavailability of herbal extracts, enriched fractions, and bioactives
Published in Journal of Microencapsulation, 2021
Debadatta Mohapatra, Ashish K. Agrawal, Alakh N. Sahu
The root of Angelica gigas Nakai (AGN) (Family- Umbelliferae) possess hydrophobic bioactives coumarins, such as decursinol angelate & decursin, which give anticancer, anti-allergic, and anti-amnestic effect. SD approach via HME was adapted to improve their solubility and antiproliferative activity. The Soluplus® based AGN-SD was found to enhance the antiproliferative effect (Jiang et al.2015). In another work, Soluplus® based AGN-SD showed improved anti-inflammatory activity and a better inhibitory effect on the human Kv1.3 potassium channel (Jiang et al.2020).