China
Africa
Explore chapters and articles related to this topic
Flavonoids with Preclinical Antidepressant-Like Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
7,8-Dihydroxyflavone is also effective in the inflammatory model of depression. Administration of lipopolysaccharide to mice increased immobility in the forced swim and tail suspension tests, and these effects were reversed by 7,8-dihydroxyflavone. Lipopolysaccharide-induced decreases in BDNF levels and dendritic spine densities in the hippocampus and prefrontal cortex were also reversed. The complexity of changes in the depressed brain were highlighted in this study with the findings that lipopolysaccharide increased BDNF and dendritic spine density in the nucleus accumbens. Those specific changes were reversed by the TrkB antagonist, ANA-12. Surprisingly, that treatment also exerted antidepressant effects.28
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?
Published in Expert Opinion on Therapeutic Targets, 2020
A. S. de Miranda, J. L. V. M. de Barros, Antonio Lucio Teixeira
In contrast to BDNF antidepressant-like activity in hippocampus, preventing BDNF production or blocking BDNF/TrkB signaling in dopaminergic reward circuitry (midbrain ventral tegmental area and nucleus accumbens) reduced anxiety toward former aggressors and induced strong antidepressive effects in rodents [22,49]. Using a combination of structure-based in silico screening and high-capacity functional assays in recombinant and neuronal cells, Cazorla et al., (2011) identified a low–molecular weight TrkB ligand named ANA-12 that inhibited the activation of TrkB by BDNF with a high potency. Systemic administration of ANA-12 (0.5 mg/kg, i.p.) in adult mice reduced TrkB signaling in the brain without affecting neuronal survival. Those mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors in various tests that were predictive of anxiolytic and antidepressant properties in human subjects.
Diagnostic value of soluble programmed cell death protein-1 in type-1 autoimmune hepatitis in Egyptian children
Published in Scandinavian Journal of Clinical and Laboratory Investigation, 2020
Ola G. Behairy, Eman G. Behiry, Manal S. El Defrawy, Ahmed N. El Adly
Regarding the diagnosis of AIH, all patients were type-1 AIH as anti-smooth muscle antibody (ASMA) was seropositive in all patients in the AIH group, while anti-nuclear antibody (ANA) was found 40% of patients of AIH group. This runs in accordance with a study done by Behairy, [11] who found that all patients were type-1 AIH as all patients were negative for anti-LKM. Regarding other auto-antibodies, 16 (64.0%) patients were positive for ANA, 12 (48.0%) for ASMA and all patients were negative for AMA.