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Benign Tumors of the Lung
Published in Philip T. Cagle, Timothy C. Allen, Mary Beth Beasley, Diagnostic Pulmonary Pathology, 2008
Alberto M. Marchevsky, Ruta Gupta
IMFT are composed of spindle cells arranged in fascicles, with or without a storiform architecture that may permeate the adjacent lung parenchyma in an infiltrating pattern that can be unexpected in light of their gross circumscription (Figs. 6 A,B) (68,74,77,81,85). The spindle cells exhibit oval nuclei with fine chromatin, inconspicuous nucleoli, and slightly eosinophilic cytoplasm (Figs. 6 C,D). The spindle cells can rarely infiltrate the blood vessels. Mitoses are infrequent. Cytologic atypia is usually absent. Touton-like giant cells, foamy histiocytes, and lympho-plasmacytic cells are frequently present admixed with the tumor cells (Figs. 7 A-D). Variable amounts of collagen bands are present. Some lesions exhibit a prominent number of plasma cells, often associated with lymphoid follicles; these lesions have been reported as “plasma cell granuloma” of the lung.
Plasma cell granuloma of the conjunctiva in a young female
Published in Orbit, 2021
Md. Shahid Alam, Vathsalya Vijay, Atanu Barh, Krishnakumar Subramanian
Plasma cell granuloma is a rare non-neoplastic inflammatory condition of unknown etiology. Histologically it is characterised by proliferation of polyclonal plasma cells, lymphocytes, neutrophils, eosinophils, and histiocytes in a fibrotic background.1 The exact etiology and natural history of these lesions remain unclear. Some authors include it within the spectrum of IgG4-related disease.2 Though any part of the body can be involved, the most frequently reported are lungs and gastrointestinal tract3 There is no consensus on the exact management of this otherwise enigmatic disorder; surgical excision, radiotherapy, steroids, and immunosuppressants have been used with varying results.4 Conjunctival disease per se is very rare and usually associated with involvement of other organs.5 The current case report describes a bilateral conjunctival plasma cell granuloma in a young patient without any systemic involvement. The present article adheres to the tenets of the declaration of Helsinki. The patient’s parents gave consent for publication of photograph and other details for research purpose.