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Rifampicin (Rifampin)
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
C. Alan, C. Street, Tony M. Korman
Elizabethkingia (formerly Chryseobacterium and Flavobacterium) meningosepticum, a Gram-negative bacillus, is a rare cause of neonatal meningitis and infections in immunosuppressed and ICU patients (Bloch et al., 1997). Rifampicin has been used successfully to treat meningitis due to this organism, usually combined with other antibiotics, such as erythromycin, vancomycin, gentamicin, or trimethoprim–sulfamethoxazole (Conti and Parenti, 1983; Di Pentima et al., 1998).
How MALDI-TOF mass spectrometry can aid the diagnosis of hard-to-identify pathogenic bacteria – the rare and the unknown
Published in Expert Review of Molecular Diagnostics, 2019
Markus Kostrzewa, Elisabeth Nagy, Percy Schröttner, Arthur B. Pranada
The ability of current MALDI-TOF MS systems to easily extend databases also enables the possibility to rapidly include emerging pathogens. This is possible because users are able to create own references with high quality for their in-house database if the manufacturer of a system gives clear guidance for the procedure and quality control, as the quality of a database has to be strictly controlled from sample preparation to quality control [107]. In 2016 the Centers for Disease Control (CDC) investigated outbreaks with Elizabethkingia anophelis causing serious infections with fatalities in the midwest of the United States (Nicholson 2016). Usually, Elizabethkingia species can be found in the environment and rarely cause infections. The CDC could quickly react and supplement their own MALDI Biotyper database. Subsequently, the commercial databases could be extended for easy identification of this new pathogen. The CDC hosted resource MicrobeNet [108] can play a key role in the rapid reaction on emerging infectious agents. As the CDC is collecting difficult to identify organisms in the USA nationwide, it has the capability to create references for its MALDI-TOF MS database very soon after a pathogen’s appearance. Thereby, these references can be made available to MALDI Biotyper users via the MicrobeNet embedded library before commercial suppliers expand their own databases.
MicroRNA Expression in Neonates with Late-onset Sepsis – A Cross-sectional Comparative Study
Published in Immunological Investigations, 2022
Saranya Sankar, Kathirvel Maruthai, Zachariah Bobby, Bethou Adhisivam
There was a newer organism outbreak Elizabethkingia species noted among the organisms isolated during our study period. Elizabethkingia species is a multi-drug resistant gram-negative organism and identified as an emerging pathogen in hospital settings. The outbreak was first identified in the United States in 1959 and reported by South Korea, Singapore, Taiwan, Hongkong and India in subsequent years. In neonates, it causes severe morbidity and mortality and is associated with hydrocephalus, deafness, and developmental delay (Masrani et al. 2019). The clinical presentation was similar to other species of gram-negative organisms.