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Suffering with two dissimilar diseases
Published in Dinesh Kumar Jain, Homeopathy, 2022
Immunity plays a very important role in the development of a disease. Hahnemann did not know about immunity and antigen-antibody reaction; that's why he did not understand the mechanism of the above observations. In the development of a disease, resistance of the host is very important. Resistance means the ability to localize and destroy microorganism. This capacity is dependent upon the presence of specific antibody that synthesizes in response to a specific antigenic stimulus. Variations in host resistance are the result of the host's ability to form antibodies. Malnutrition (especially protein deficiency), toxic depression due to bacterial toxins, and hormonal imbalance can greatly depress synthesis of antibodies. Anything that reduces the number of leukocytes also reduces resistance.
Dermal Hypersensitivity: Immunologic Principles and Current Methods of Assessment
Published in David W. Hobson, Dermal and Ocular Toxicology, 2020
The same immune mechanisms that furnish both resistance against infections and so-called “immune-surveillance of neoplasia” can also produce immunopathologic disease (a “double-edged sword” effect).17,63 Cell-mediated immunity becomes harmful during delayed hypersensitivity reactions that cause tissue damage, such as in ACD, graft-vs.-host disease, certain autoimmune disorders, and larger space-occupying granulomas.18 Likewise, humoral immunity can also damage host tissues during immediate hypersensitivity reactions, such as in anaphylaxis, immune-complex disease, and cytotoxicity of host cells. As with disease resistance, hypersensitivity can involve either or both of these arms of acquired immunity, depending on a multitude of variables.17,18,48,49
Psychoneuroimmunology, Stress and Disease
Published in Herman Friedman, Thomas W. Klein, Andrea L. Friedman, Psychoneuroimmunology, Stress, and Infection, 2020
Michael Schlesinger, Yair Yodfat
Stressful life events and other psychosocial factors may increase the susceptibility to illnesses and mortality.2,3 In 1952 Hinkle and Plummer4 showed that telephone company employees with high illness-absentee rates reported higher levels of dissatisfaction with life and 12 times the number of minor respiratory illnesses than a control sample of workers with low absence rate. Beautrais et al.5 showed that hospital admissions and general practitioner consultations for lower respiratory tract illness, gastroenteritis, accidents, poisoning, burns/scalds, and suspected home related conditions in 1 to 4 year old children were highly correlated with the number of family life events. Children from families with more than 12 life events were 6 times more likely to have been hospitalized. According to Plaut and Friedman6 primary and mediating variables contribute to the relation between stressors and disease resistance. The primary variables are stress, coping, and disease parameters such as weight loss, illness, behavior, etc. The mediating variables are situational factors (nutrition, circadian rhythms, temperature and extraneous stimulation), psychosocial mechanisms (e.g., differential housing and life changes), genetic and environmental history, and physiological mechanisms (e.g., hormonal mechanisms).
Orobanche foetida resistance in two new faba bean genotypes produced by radiation mutagenesis
Published in International Journal of Radiation Biology, 2018
Sonia Mejri, Yassine Mabrouk, Omrane Belhadj, Mouldi Saidi
Gamma irradiation can induce systemic acquired resistance (SAR) in plants against the pathogens. Breeding for disease resistance is easy when a good source of resistance is available. Unfortunately, this is not the case in faba bean against broomrape, where the only incomplete resistance of complex inheritance has been identified (Maalouf et al. 2011). Resistance identified in faba bean was attributed to mechanisms operating against the establishment of germinated broomrape seeds and inhibiting the penetration through the host tissues as well as hampering the tubercle development (Abbes et al. 2007; Pérez-de-Luque et al. 2010). As a consequence, differences in resistance, caused by diverse mechanisms, which could account for the remaining variation, might be under-represented by the simple scoring of the final number of emerged orobanche shoots.
The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation
Published in Acta Oto-Laryngologica, 2018
Shufeng Wu, Huan Shi, Ningning Cao, Lei Ye, Chuangqi Yu, Lingyan Zheng
In general, the level of immunoglobulins among children ranged from 7 to 13 years was much higher compared with the preschool children groups, which was represented in both JRP patients and normal children. It revealed that immune function enhanced by age, so was the disease resistance. For JRP patients, serum IgG level between 7 and 13 years was greater than in the preschool children (p < .05; Figure 1). For normal children, there was significant difference for IgA and IgG in different groups, which showed that the serum IgA and IgG levels between 7 and 13 years was greater than in the preschool children (p < .01; Figure 1), which revealed that the development of immune function was built up with the growing.
“ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities
Published in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018
Daniel Harrison, Paul Mehta, Michael A. van Es, Elijah Stommel, Vivian E. Drory, Beatrice Nefussy, Leonard H. van den Berg, Jesse Crayle, Richard Bedlack
Finally, it is possible that our cases have genetic differences that confer disease resistance. There is a precedent for this in HIV elite controllers, and that discovery led to an effective treatment, maraviroc, for patients with HIV (23). One possibility is that some of these patients have mutations that lead to enhanced reinnervation. This might be of particular benefit in purely lower motor neuron disease, which was prevalent in our cases. We plan to perform whole genome sequencing on ALS reversals to determine if they differ genetically from patients with more typical ALS progression. By better understanding ALS reversals, we hope to make them happen more often.