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Mezlocillin, Azlocillin, Apalcillin, and Piperacillin
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Adrian Tramontana, Karin Thursky
Aeromonas spp. are usually piperacillin sensitive, except Aeromonas jandaei, which is usually resistant (Koehler and Ashdown, 1993; Overman and Janda, 1999). High rates of resistance among other non-veronii Aeromonas spp. have been seen in biliary isolates from patients with cholangitis (Chan et al., 2000). Most isolates of Achromobacter xylosoxidans are susceptible (Mandell et al., 1987). Chryseobacterium indologenes is usually susceptible to piperacillin, whereas around 60% of C. meningosepticum isolates are susceptible (Kirby et al., 2004).
Phenotypic synergy testing of ceftazidime–avibactam with aztreonam in a university hospital having high number of metallobetalactamase producing bacteria
Published in Infectious Diseases, 2020
Chinmoy Sahu, Sourav Pal, Sangram Singh Patel, Sanjay Singh, Mohan Gurjar, Ujjala Ghoshal
MDR bacteria cause significant problem in choosing the right antibiotic. Multiple factors contribute to the problem. Majority of MDR, carbapenem-resistant bacteria are isolated from inpatients having hospital acquired infections. They usually have multiple co-morbidities, immunosuppression, prior antibiotic use history etc. Resistance to safer drugs like carbapenems often pose challenge in antibiotic therapy especially in hospitals having high load of mellaobetalactamse-producing bacteria. Colistin, the last line of defence often can’t be used in these patients due to toxicity. Some bacteria like Stenotrophomonas maltophilia, Chryseobacterium indologenes and Proteus spp. are intrinsically resistant to colistin. So, in many cases, the clinicians look for other alternative antibiotics.
Dilemma in identifying Chryseobacterium species
Published in Infectious Diseases, 2018
With reference to the recently published manuscript titled “Chryseobacterium bacteraemia: a single-centre case series” by Perez et al. [1], six isolates of Chryseobacterium indologenes along with one isolate of Elizabethkingia meningoseptica were reported as cause of bacteraemia in patients with severe underlying conditions. These isolates were identified using automated methods and also using MALDI-TOF mass spectrometry (Bruker Daltonics, Bremen, Germany) since 2014. Accurate identification holds the key for such unusual organisms for their appropriate management strategies. We, hereby, would like to highlight that even though MALDI-TOF mass spectrometry is a valuable tool for diagnosis and identification of unusual pathogens, discrepancies in correct identification of Chryseobacterium and Elizabethkingia species have been cited in recent documented studies [2–5].
Chryseobacterium bacteraemia: a single-centre case series
Published in Infectious Diseases, 2018
Justo Sandino Pérez, Ana Maria Mancilla, Edgar Pérez Barragán, Mario Fernández-Ruiz
In patients with severe underlying conditions, the mortality resulting from infections due to Gram-negative bacteria is considerable. In a previous study on shock and mortality in solid organ transplant recipients reported in the present journal [1], the authors focused on non-lactose-fermenting Gram-negative bacteria, which are naturally resistant to commonly used antibiotics and increasingly important among immunocompromised hosts. Drug resistance and attributable-mortality rates were very high in the experience reported by Wan et al. [1]. Herein, we focused on one of these agents. Chryseobacterium indologenes, formerly known as Flavobacterium indologenes or F. aureum, is a catalase-, oxidase- and indole-positive, non-motile and non-fermenting Gram-negative bacillus. It is rarely identified as the causative agent in episodes of bacteraemia, pneumonia, meningitis and lumboperitoneal shunt infection, especially among hospitalized patients with previous antibiotic exposure and indwelling devices [2–4]. In addition, C. indologenes is intrinsically resistant to certain broad-spectrum antibiotics due to the presence of several classes of β-lactamases (including a carbapenem-hydrolysing metallo-β-lactamase [IND1 to IND7]) [5].