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Hip preservation techniques
Published in K. Mohan Iyer, Hip Preservation Techniques, 2019
Cartilage restoration can be achieved using different techniques, such as (1) microfracture surgery, (2) drilling, (3) abrasion arthroplasty, (4) autologous chondrocyte implantation, (5) osteochondral autograft transplantation, and (6) osteochondral allograft transplantation, and expanded mesenchymal stem cells seeded in a collagen membrane injected into hip chondral lesions were beneficial and showed promising results as reported in the Journal of Hip Preserving Surgery 2 years ago.
Treatment of glenohumeral chondral defects
Published in Andreas B. Imhoff, Jonathan B. Ticker, Augustus D. Mazzocca, Andreas Voss, Atlas of Advanced Shoulder Arthroscopy, 2017
Timothy S. Leroux, Michael L. Redondo, Brian J. Cole
Following surgery, all patients are placed in a sling. They are discharged home on the same day with adequate analgesia. For arthroscopic procedures that do not involve subscapularis take down, early range of motion is encouraged as tolerated. For open grafting procedures that involve repair of a subscapularis take down, the repair is protected by limiting active and passive external rotation to 20° and limiting active internal rotation for 6 weeks. Patients can otherwise range their shoulder as tolerated. We do not use continuous passive motion, but this is an option for patients following microfracture surgery, where motion is permitted without restriction. If needed, a formal physical therapy program is initiated at 6 weeks post-surgery, focusing on restoring range of motion, and later strengthening of the periscapular muscles and rotator cuff.
Microfracture technique combined with mesenchymal stem cells inducer represses miR-708-5p to target special at-rich sequence-binding protein 2 to drive cartilage repair and regeneration in rabbit knee osteoarthritis
Published in Growth Factors, 2023
YongChao Wang, Qin Su, HaiRong Tang, Qiang Tian, Xin Lin, MeiChun Fu, RenMing Zhang, ZhangFeng Luo, KeYun Zhang
Clinically, microfractures are often applied to repair cartilage alone or in combination with other techniques. For instance, microfracture combined with perforated decalcified cortical-cancellous bone matrix scaffold is employed for the one-step repair of rabbit cartilage defects (Dai et al. 2014). In this study, microfracture surgery combined with intra-articular injection of KGN was to figure out its effect on cartilage repair and its latent mechanism. KGN is a tiny molecule that has been manifested to stimulate MSCs to differentiate into chondrocytes in vitro and vivo (Xu et al. 2021). The results of this study displayed that microfracture technology combined with MSCs inducers was available to effectively restrain inflammatory factors, MMP-1 and MMP-3, mitigate cartilage tissue and synovial tissue damage, and elevate cartilage tissue type II collagen content and TIMP −1, and has a better therapeutic effect in comparison to microfracture alone. Meanwhile, it was also confirmed that Microfracture + KNG worked in KOA by targeting the miR-708-5p/SATB2 axis.
Cost-effectiveness analysis of arthroscopic injection of a bioadhesive hydrogel implant in conjunction with microfracture for the treatment of focal chondral defects of the knee – an Australian perspective
Published in Journal of Medical Economics, 2022
George Papadopoulos, Sarah Griffin, Hemant Rathi, Amit Gupta, Bhavna Sharma, Dirk van Bavel
Patients suffering from symptomatic focal chondral defects (Outerbridge Grade 3 or 4) of the knee, having failed conservative treatment, and indicated for surgery were included in the analysis. The intervention investigated in this analysis was JointRep in combination with microfracture surgery compared to microfracture surgery alone. Microfracture surgery alone is considered the gold standard of surgical treatment of chondral defects in the Asia Pacific, and hence was used as a comparator for this analysis20.