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High-Dimensional, Penalized-Regression Models in Time-to-Event Clinical Trials
Published in Susan Halabi, Stefan Michiels, Textbook of Clinical Trials in Oncology, 2019
Federico Rotolo, Nils Ternès, Stefan Michiels
The entire prediction model (126 variables) has a moderate ability to discriminate patients according to their survival probability (C-statistics = 0.67 with double cross-validation). Regarding the treatment-effect modifying component of the model, it only slightly discriminates between patients in terms of their treatment benefit (ΔC = 0.02 with double cross-validation): the lower the treatment-effect modifying score, the higher the benefit of the trastuzumab. In terms of point estimates, the effect of treatment with trastuzumab on absolute DRFS seems higher for the low treatment-effect modifying scores. However, the width of the confidence intervals is extremely large, and the confidence intervals overlap a great deal between the two arms.
Influence of thermocycling and colorants in the color of a bis-acryl composite resin—in vitro study
Published in J. Belinha, R.M. Natal Jorge, J.C. Reis Campos, Mário A.P. Vaz, João Manuel, R.S. Tavares, Biodental Engineering V, 2019
M.G.F. de Macedo, C.A.M. Volpato, B.A.P.C. Henriques, P.C. Vaz, F.S. Silva, C.F.C.L. Silva
When the disks were submitted to thermocycling, the color differences (ΔE00) became more evident as the cycles increased. The largest color differences were observed in the unpolished group (3.73), although all polished groups presented differences close to 3ΔE00 for 200 cycles (Table 1). Both groups and aging were significant statistically (P = 0.02 and P < 0.001, respectively). For all groups, the color difference (ΔE00) found is mainly related to the decrease in chroma (ΔC′) and the increase in hue (ΔH′) (P < 0.001).
Hyperglycemia Impairs the Functions of Blood
Published in Robert Fried, Richard M. Carlton, Type 2 Diabetes, 2018
Robert Fried, Richard M. Carlton
Patients with lower hemoglobin concentrations were shown to have a longer duration of diabetes, a lower BMI, and lower concentrations of total cholesterol, triglycerides, and LDL cholesterol. They also had lower levels of postprandial C-peptide, Δ C-peptide, and postprandial β-cell responsiveness. They also had a higher prevalence of retinopathy and nephropathy. It was found that there was a significant association between nephropathy and hemoglobin concentration. Also, hemoglobin concentrations were independently associated with Δ C-peptide levels, and postprandial β-cell responsiveness (Kwon, and Ahn. 2012).
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Mohammed Farrag El-Behairy, Walaa Hamada Abd-Allah, Mohamed M. Khalifa, Mohamed S. Nafie, Mohamed A. Saleh, Mohammed S. Abdel-Maksoud, Tarfah Al-Warhi, Wagdy M. Eldehna, Ahmed A. Al‐Karmalawy
Compounds 4a–g have been characterised by NMR and Mass spectroscopy as described in the experimental section and supporting information. In 13C-NMR, two signals corresponding to carbonyl carbon have been observed at δC 164–169 and δc 153–157 ppm. Also, all aromatic carbons were observed at δC 100–150 ppm, and the aliphatic methyl of 4d and methylene of 4g were detected at δC 21.5 and 45 ppm, respectively. The 1H-NMR showed only aromatic protons for all compounds except compound 4d, which displayed methyl signal at δH 2.29 ppm, and compound 4g, where a very characteristic triplet resulted from overlapped doublet of doublet signals of the prochiral methylene group was noted at δH 1.15 ppm. The most characteristic signal of compounds 4a–g is the amidic NH singlet signal at δH 10.0 ppm, while the other amidic NH was observed at δH 7.0–8.0 ppm, very close to aromatic protons. The mass spectra of compounds 4a–g were performed using negative mode ESI and showed the molecular ion signal as a minor peak, but the [M-H]– was present in all spectra as the base peak.
Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Mohammad M. Al-Sanea, Tamer M. Nasr, Samir Bondock, Aya Y. Gawish, Nada M. Mohamed
On the other hand, derivatives 3b and 3c were distinguished with their carbonyl substituents that showed prominent peaks in their IR and 13C NMR spectra at ύ 1655 cm−1 and δc 188–189.1 ppm, respectively. In addition to their aliphatic protons which appeared at δH 2.25–2.49 ppm and 1.32–4.22 ppm for 3b and 3c, respectively. Their corresponding aliphatic carbons were displayed at δc 18.4–29.7 ppm and 14.3–60.2 ppm for 3b and 3c, respectively. Similar to 3b, derivative 9 possessed a methyl ketone and a methyl substitution that appeared at δH 1.2–2.4 ppm and δc 14.1–60.5 ppm for methyl and methyl ketone, respectively. From their mass spectrum, compounds 5a, 5b, 6a, 6b, 8a and 8b showed the phenyl ring fragment at m/z 77. Moreover, the phenyl imine (Ph-N=) bond formation of 8a–c was confirmed by the presence of their mass fragments at m/z 91–92. It was noticed that 5a had poor solubility in DMSO that reflected weak signals in both NMR spectra.
What is the nutritional status of patients with prolonged disorders of consciousness? A retrospective cross-sectional study
Published in Brain Injury, 2023
Camilla Ippoliti, Marjorie Fadeur, Christian Malherbe, Jenny De Flines, Anne-Marie Verbrugge, Olivia Gosseries, Didier Ledoux, Benoit Misset, Steven Laureys, Nicolas Paquot, Aurore Thibaut
Regarding the link between BMI and ΔC, the ΔC was significantly higher in the obese group of patients compared to the patients with a normal BMI and to the ones who are underweighted. This result shows that patients who are obese are the ones in which the difference between their DCN and the RCI is higher (−630 kcal). On the other hand, patients whose RCI is superior to the DCN (+106 kcal) are underweighted. Considering that there are no significant differences in the RCI among patients with different diagnosis and etiology, other factors need to be considered, such as dysfunction of the hypothalamus. Indeed, it is well accepted that the brain, notably the hypothalamus and its complex network, plays a crucial role (22). Food intake, besides external factors (e.g. emotions), is influenced by internal factors, such as the ‘energy homeostasis’ regulatory process that promotes stability in the amount of body energy stored in the form of fat (22). The hypothalamus represents the major center controlling for food intake and body weight; more precisely, the ventromedial hypothalamic nucleus is the ‘satiety center,’ while the lateral hypothalamic area is the ‘hunger center’ (23). More recently, the notion of specific brain’s loci controlling for food intake and body weight has been replaced by the importance of neuronal pathways that generate integrated responses to afferent input related to changing body fuel stores (22). Further investigations including neuroimaging are necessary to study possible hypothalamus dysfunction and the neural pathways involved in energy needs and body weight in DoC patients.