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Pregnancy
Published in T. Yee Khong, Annie N. Y. Cheung, Wenxin Zheng, Richard Wing-Cheuk Wong, Hao Chen, Diagnostic Endometrial Pathology, 2019
T. Yee Khong, Annie N. Y. Cheung, Wenxin Zheng
An infrequent finding in abnormal uterine bleeding is the placental site nodule or plaque (see also Chapter 10). These are usually microscopic singular or multiple well-circumscribed plaques that are extensively hyalinized, giving an eosinophilic fluffy appearance (Figures 3.28 and 3.29). Rarely, they can be identified grossly. These nodules are generally paucicellular but persistent extravillous trophoblast is present within these nodules indicating their origin from a pregnancy that had occurred either knowingly up to several years previously or unbeknown to the woman.23 Apart from this lack of immediate temporal relationship to pregnancy, they do not differ significantly from the nodules that are present in subinvolution of the placental bed.
Gestational Trophoblastic Neoplasia
Published in Dongyou Liu, Tumors and Cancers, 2017
Ansar Hussain, Shiekh Aejaz Aziz, Gul Mohd. Bhat, A. R. Lone
Encompassing both benign and malignant lesions arising from the anomalous growth of trophoblastic tissue within the uterus, gestational trophoblastic diseases (GTDs) are classified into (1) trophoblastic neoplasms (choriocarcinoma, placental site trophoblastic tumor [PSTT], epithelioid trophoblastic tumor [ETT]), (2) molar pregnancies (hydatidiform mole [HM]—complete, partial, invasive, metastatic), and (3) nonneoplastic, nonmolar trophoblastic lesions (placental site nodule [PSN] and plaque, exaggerated placental site [EPS]) [1].
Management of trophoblastic tumors : review of evidence, current practice, and future directions
Published in Expert Review of Anticancer Therapy, 2023
Antoine Deleuze, Christophe Massard, Fanny Le Du, Benoit You, Claudia Lefeuvre-Plesse, Pierre-Adrien Bolze, Thibault de la Motte Rouge
Premalignant forms encompass partial hydatidiform moles (PHM), CHM, and atypical placental site nodule (APSN). PHM have a triploid genome and arise from the fertilization of a haploid egg either by a single sperm with subsequent paternal chromosomes duplication or via dispermy. CHM are mostly monospermic 46×X developing after the fertilization of an empty egg by one sperm followed by duplication and more rarely dispermic 46×X or XY, arising from fertilization of an empty egg by two sperms. Hydatidiform moles are characterized by a trophoblastic proliferation associated with vesicular swelling of placental villi. PHM is usually associated with an abnormal fetus as the presence of both maternal and paternal chromosomes allows the development of embryonic tissue, whereas CHM is associated with the absence of fetal development [1,8]. The immunohistological staining for p57 is usually negative in CHM and found positive in PHM.
Retained pregnancy tissue after miscarriage is associated with high rate of chronic endometritis
Published in Journal of Obstetrics and Gynaecology, 2022
Dana B. McQueen, Kruti P. Maniar, Anne Hutchinson, Rafael Confino, Lia Bernardi, Mary Ellen Pavone
Finally, while no women in the RPL cohort were suspected to have RPT on their initial evaluation, three women had an incidental implantation site or placental site nodule identified in their endometrial biopsy specimen. Interestingly, in all three of these cases, chronic endometritis was found.