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Deep Tissue Hyperalgesia
Published in Robert M. Bennett, The Clinical Neurobiology of Fibromyalgia and Myofascial Pain, 2020
Lars Arendt-Nielsen, Thomas Graven-Nielsen
In humans little information is available on the peripheral neuronal correlate of muscle nociceptor sensitization and only few microneuro-graphic studies have been published (4,5). The reason is difficulties in recording and directly activation of the muscle nociceptors. Other more indirect but still quantitative techniques are therefore needed, and quantitative sensory testing may help to assess muscle pain and hence muscle hyperalgesia. As there have been made substantial achievements in this field in recent years, a short update will be given in the following.
Female Sexual Dysfunction
Published in Linda Cardozo, Staskin David, Textbook of Female Urology and Urogynecology - Two-Volume Set, 2017
Seth D. Cohen, Irwin Goldstein
Figure 64.12 (A) A biothesiometer meAsures vibrAtory perception thresholds (expressed in volts) on A genitAl reference site (index finger) As well As in multiple genitAl sites such As the glAns clitoris (dorsAl nerve of the clitoris) And the right And left lAbiA minorA (the perineAl nerve). (b) QuAntitAtive sensory testing involves determinAtion of hot And cold perception threshold vAlues in the sAme test sites As the biothesiometer.
Sensory testing and clinical neurophysiology
Published in Harald Breivik, William I Campbell, Michael K Nicholas, Clinical Pain Management, 2008
Ellen Jørum, Lars Arendt-Nielsen
In conclusion, quantitative sensory testing has a role to play in clinical neurophysiology, neurology, and pain management. The challenge for the future is to develop techniques to: assess not only the pain pathways as such but also, in more detail, the various mechanisms involved;investigate pain originating not only from skin but also from deeper structures.
Ultrasound-guided percutaneous electrical stimulation for a patient with cubital tunnel syndrome: a case report with a one-year follow-up
Published in Physiotherapy Theory and Practice, 2022
César Fernández-de-Las-Peñas, José L. Arias-Buría, Youssef Rahou El Bachiri, Gustavo Plaza-Manzano, Joshua A. Cleland
Finally, we acknowledge that a case report does not allow us to infer a cause-and-effect relationship. Further, the patient’s diagnosis and treatment selection were mainly based on clinical examination and self-reported symptoms. It has been reported that ultrasound nerve assessment may reveal a swollen and hypoechoic nerve characteristic of ulnar neuropathy (Simon et al., 2015). Future trials investigating ultrasound and electromyographic changes within the ulnar nerve after application of ultrasound-guided PENS should be conducted. Similarly, our outcomes assessed sensory and motor symptoms self-reported by the patient. It may be valuable to analyze changes in quantitative sensory testing associated to neuropathic pain (e.g. mechanical detection thresholds or thermal thresholds, after the application of PENS).
Restoration of the penile sensory pathway through end-to-side dorsal root neurorrhaphy in rats
Published in The Journal of Spinal Cord Medicine, 2022
Hao Zhang, Shuaishuai Chai, Qiufeng Pan, Bing Li
Despite these encouraging findings, this study has several limitations. Firstly, in our research, no functional experiments were performed to quantitatively analyze the recovery of PS in the rats. In clinical studies, self-reported and quantitative sensory testing are commonly used to evaluate sensory function.3,4,27 However, these methods cannot to be applied to animals. Finding a reliable detection method to quantitatively measure the degree of sensory restoration in rats will be one of the main focuses in our next experiments. Secondly, to reduce the rate of mortality among the rats, we did not damage the spinal cord of rats before neurorrhaphy. Instead, we used bilateral afferent nerve resection to simulate the loss of penile sensation after SCI, which differs from the actual situation of clinical patients. Thirdly, the present study did not describe the specific mechanism of neural regeneration induced by the procedure in the rats. Although the previous studies have shown that the transfer of DR does not cause significant donor nerve damage or trigger DREZ inhibitory effects,12–14 the detailed mechanism needs to be further studied. Moreover, the animal model used in our work is quite different from the human body, and the number of animals we used was limited. Therefore, the relevant results need to be verified through large animal models and autopsy experiments.
The time to develop treatments for diabetic neuropathy
Published in Expert Opinion on Investigational Drugs, 2021
2.2 QUANTITATIVE SENSORY TESTING: Due to the variability of clinical assessment, in an attempt to better standardize the clinical assessment of sensory function, various quantitative sensory testing (QST) devices have been developed [43,44]. These devices create sensory stimuli and rely on the subject’s response to define sensory thresholds. Many devices have been developed for quantitative sensory testing of vibration, thermal sensation, light touch, and current perception. These measures are necessarily subjective and require quantitation. QST is painless and noninvasive, requires minimal training and is relatively easy to perform. However, the variability is high, requiring a large sample size for confirmatory results [45–47]. There is only a low to moderate correlation with nerve conduction study values, resulting in potential statistical discrepancies in longitudinal studies of agents to treat diabetic neuropathy [48,49].