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Investigation of COVID-19 Chest X-ray Images using Texture Features – A Comprehensive Approach
Published in S. Prabha, P. Karthikeyan, K. Kamalanand, N. Selvaganesan, Computational Modelling and Imaging for SARS-CoV-2 and COVID-19, 2021
J. Thamil Selvi, K. Subhashini, M. Methini
The Statistical Feature Matrix (SFM) extracts visual texture features by considering the intersample spacing between the pixels [Loizou et al., 2015]. Features such as Coarseness, Contrast, Periodicity and Roughness are extracted from normal and abnormal chest X-ray images, then extracted and analysed.
Treatment of pre-eclampsia
Published in Pankaj Desai, Pre-eclampsia, 2020
Even a regular antenatal check-up can alert the clinician to a possibility of the baby not thriving within. This needs just an average experience and no extraordinary expertise. Most clinicians have done away with the practice of measuring the SFM. In such a situation, even regular alert palpation of the fundus and assessing its height with context to the weeks of gestation as per the menstrual age is sufficient for the same.
Schimmelpenning–Feuerstein–Mims Syndrome
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Schimmelpenning–Feuerstein–Mims (SFM) syndrome is a RASopathy that results from mosaicism secondary to postzygotic mutations in the HRAS, KRAS, and NRAS genes during the early embryonic period [16]. Clinically, this disorder is characterized by classical sebaceous nevus on the scalp, forehead, neck and trunk, along with multisystem involvement (neurological, ocular, renal, cardiac, or skeletal anomalies) [17,18]. Sebaceous nevus is a congenital skin hamartoma that typically appears as a yellow-hued plaque (its occurrence along Blaschko's lines suggests a mosaic genetic mutation), displays epidermal acanthosis and hyperplasia or structural abnormalities of sebaceous glands and hair follicles, and has the potential of developing into secondary benign tumors (e.g., trichoblastoma and syringocystadenoma papilliferum) as well as malignant tumors (e.g., basal cell carcinoma) [19]. Diagnosis of SFM syndrome involves observation of characteristic clinical features. Identification of HRAS, KRAS, and NRAS mutations in tumor specimens is informative but nonspecific for SFM syndrome. Treatment of this disorder relies on standard procedures that provide symptomatic relief and improve cosmetic appearance for affected individuals.
Effect of standardized fluid management on cardiac function after CRS + HIPEC in patients with PMP: a single-center case-control study
Published in International Journal of Hyperthermia, 2023
Rui Yang, Yan-Dong Su, Gang Liu, Yang Yu, Xin-Bao Li, Xin Zhao, Zhong-He Ji, Ru Ma, Zhi-Ran Yang, Yu-Lin Lin, He-Liang Wu, Yan Li
Clinically, doctors usually dynamically adjust infusion volume by monitoring various postoperative outputs, NT-ProBNP, CVP and other clinical indicators of patients, thereby avoiding too much or too little rehydration. However, in clinical practice, there are significant differences in the experience of postoperative fluid management among clinicians, and it is challenging to standardize and individualize postoperative fluid management. Such variations inevitably affect clinical outcomes. To minimize such differences, we designed a standardized postoperative fluid management tool to optimize postoperative fluid management and realize real-time, dynamic, individualized SFM, which can reduce postoperative cardiovascular SAEs. This study showed that a postoperative CTNI > 2 × ULN was an independent risk factor for postoperative cardiovascular SAEs, and a CTNI > ULN was an independent prognostic factor. SFM can significantly reduce the probability and degree of CTNI abnormalities and the risk of postoperative cardiovascular SAEs. Gorgun et al. [24] showed that the postoperative CTNI level in patients undergoing gastrointestinal surgery was associated with 30-day to 1-year postoperative mortality. Other studies have shown [25–28] that preoperative calponin levels in patients undergoing non-cardiac surgery have a predictive value for postoperative cardiovascular SAEs. Both preoperative and postoperative troponin levels are important risk predictors of postoperative SAEs, and treatment strategies should be promptly adjusted in response to troponin levels.
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery
Published in Pharmaceutical Development and Technology, 2021
Wipada Samprasit, Praneet Opanasopit, Benchawan Chamsai
The cytotoxicity and anti-tumour activity of NPs without α-mangostin (blank NPs) and α-mangostin-loaded NPs was tested on normal human fibroblast (NHF) and human colorectal adenocarcinoma cells (HT-29), respectively. The cells were cultured in DMEM supplemented with 10% FBS, 2 mM L-glutamine, 100 IU/mL penicillin, 100 μg/mL streptomycin, and 5 μg/mL amphotericin B at 37 °C in a humidified atmosphere of 95% air and 5% CO2. The NPs were sterilized by UV radiation for one hour before testing. The cells were seeded at 10 000 cells per well in 96-well plates. When the cultures reached confluence, the cells were treated with NPs at concentrations ranging from 0 to 600 μg/mL in a serum-free medium (SFM) and subsequently incubated for 24 h. The SFM was used because it did not contain the protein which may not enhance and suppress the effect of the tested drug. After treatment, the cytotoxicity and anti-tumour activity was examined by MTT assay. The cells were incubated with 200 µL of MTT solution (0.5 mg/mL in DMEM without phenol red) in a CO2 incubator for 1 h. The solution was then removed and 500 µL of DMSO was added. The cell viability (%) was calculated based on the absorbance at 570 nm using a Genesis10 UV-visible spectrophotometer. For the blank NPs, the viability of the non-treated cells was arbitrarily defined as 100%. In the case of α-mangostin-loaded NPs, the 100% of cell viability was the cells exposed to the respective concentration of blank NPs.
Inter-rater reliability of DartfishTM movement analysis software for measuring maximum flexion and extension at the hip and knee in older adults with osteoporosis and osteopenia
Published in Physiotherapy Theory and Practice, 2019
Tyler Allen, Zachary Hollingham, James MacWhirter, Mark Welsh, Ahmed Negm, Jonathan D. Adachi, Norma J. MacIntyre
The Safe Functional Motion test (SFM) is used to assess habitual movement patterns during activities of daily living (ADLs) among individuals at risk for osteoporotic fracture (MacIntyre, Recknor, Grant, and Recknor, 2013; Recknor, Grant, Recknor, and MacIntyre, 2013). During the SFM, individuals are asked to perform 10 tasks, which represent the spectrum of typical daily activities performed by older adults (Recknor, Grant, Recknor, and MacIntyre, 2013). An individual’s task performance is evaluated and scored based on six physical function domains: spinal compression forces, balance, upper body strength, lower body strength, upper body flexibility, and lower body flexibility (Recknor, Grant, Recknor, and MacIntyre, 2013). SFM scores have been shown to predict incident vertebral fracture in individuals with OP (MacIntyre, Recknor, Grant, and Recknor, 2013), and movement patterns that employ less spinal flexion (through hip/knee flexion patterns) result in better SFM scores (Recknor, Grant, Recknor, and MacIntyre, 2013).