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Bio-Implants Derived from Biocompatible and Biodegradable Biopolymeric Materials
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
Polybutylene succinate (PBS based different blends are tried gave greater toughness. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(butylene succinate-co-adipate) (PBSA) biodegradable polymers some of them [39]. These polymers were added to a PLA/PBAT blend giving a decrease of thermal properties. There is an observation of an increase in melt flow with PBS, as it is more flexible compared to the other. There is no change in melt flow observed with PBSA or PHBV [40]. PLA degrades into water and carbon dioxide that does not cause any harm; they can be cleared out of human body, thus PLA became the most popular biomedical material in the market.
Enhanced Scaffold Fabrication Techniques for Optimal Characterization
Published in Naznin Sultana, Sanchita Bandyopadhyay-Ghosh, Chin Fhong Soon, Tissue Engineering Strategies for Organ Regeneration, 2020
Tshai Kim Yeow, Lim Siew Shee, Yong Leng Chuan, Chou Pui May
Lu et al. (2011) fabricated biodegradable poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffolds into a meniscal shape by solvent casting particulate leaching technique. During the fabrication, the slurry of salt and chloroform dissolved PHBV were poured into a prefabricated mold in the shape of a rabbit meniscus (10 mm in length, 6 mm in width, and 2 mm in thickness). It was observed that 18 weeks after transplantation of proliferated meniscal cells seeded PHBV scaffolds into rabbit knee joints, the cell-seeded scaffolds maintained their approximate shape and showed ideal initial mechanical properties and biocompatibility (Lu et al. 2011).
Fabrication of long-acting insulin formulation based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles: preparation, optimization, characterization, and in vitro evaluation
Published in Pharmaceutical Development and Technology, 2019
Samane Bayrami, Zahra Esmaili, SeyedAhmad SeyedAlinaghi, Saeed Reza Jamali Moghadam, Sepide Bayrami, Hamid Akbari Javar, Morteza Rafiee Tehrani, Farid Abedin Dorkoosh
Among a number of natural and synthetic polymers, PHBV has attracted attention due to its favorable properties such as biocompatibility, biodegradability, low-cost production, and noncytotoxicity of its degraded products (Sheu et al. 2009). The focus of this study was achieving a sustained drug delivery system with high encapsulation efficiency. DOE is identified as a highly automated statistical technique for designing, modeling, and analyzing the influence of variables on the predetermined response with a minimum sample size (Baş and Boyacı 2007). In this study, BBD was used for optimization and quantification the effects of PVA, PHBV, and insulin concentration on properties of NPs such as size, EE, and PDI which are the subject of the greatest significance in clinical application of NPs (Amasya et al. 2016; Alzubaidi et al. 2017). Based on the DOE results, the polymer concentration influences positively on the particle size of NPs owing to its direct impacts on the viscosity.
Prolonged injectable formulation of Nafarelin using in situ gel combination delivery system
Published in Pharmaceutical Development and Technology, 2018
Behnoush Alizadeh, Nika Bahari Javan, Hamid Akbari Javar, Mohammad Reza Khoshayand, Farid Dorkoosh
One of the common strategies to sustain the release profile of peptides and proteins is nanoparticles drug delivery systems (Tan et al. 2010). NPs have been recommended as valuable carriers for protection of peptides and proteins from adverse degradation and they also display great stability and high loading capacity (Mohanraj et al. 2006; Mohanraj & Chen 2007). The most extensively used polymers are polylactic-co-glycoloic acid (PLGA), polylactic acid (PLA), polycaprolactone (PCL), and polyalkyl cyanoacrylates (Kumari et al. 2010; Pal et al. 2011). Despite the wide usage of the aforementioned polymers in designing long-acting formulations of various therapeutic agents, there are still some issues remained unresolved. One of these problematic issues is swift degradation of PLGA which may lead to creation of an acidic environment. Aggregation and denaturation of peptides and proteins are the undesirable result of this issue which can cause immunogenicity. Crystalline residues which are remained even after several years due to slow degradation of some polymers like PLA is another problem worth noticing (Bahari Javan et al. 2016). Finally, high adhesiveness of cyanoacrylates, which results in both low elasticity and low resistance to chemical and physical attack, has limited the application of the aforementioned polymers (Lim & Kim 2015). In order to eliminate the disadvantages of widely used polymers, we have selected an alternative polymer named PHBV. PHBV is a biocompatible (Fukada & Ando 1986), biodegradable (Koosha et al. 1989), and non-toxic (Pouton & Akhtar 1996) polymer. Also the lower degradation rate of PHBV compared with PLGA and the higher degradation rate compared with PLA solves the issues outlined above (Kose et al. 2005).
Effects of rosiglitazone/PHBV drug delivery system on postoperative fibrosis in rabbit glaucoma filtration surgery model
Published in Drug Delivery, 2019
Feng Zhang, Ke Liu, Zheng Pan, Mengdan Cao, Dengming Zhou, Hairong Liu, Yuting Huang, Xuanchu Duan
PHBV has been a significant progress in the field of medical study. This polymer material is easily to get and harmless to environment in the produce process. Moreover, it is rather cheaper than other technologies. We combine rosiglitazone and PHBV by electrospinning. Similarly, rosiglitazone is a cheap medicine and easily acquired. Our study showed the application prospect of RSG/PHBV membrane and the use of electrospinning in medicine. Whereas, the long-term effectivity and safety of RSG/PHBV membrane need to observe in the next experiments.