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Gnetum gnemon L.) leaves extract and beta cyclodextrin as a stabilizer
Published in Ade Gafar Abdullah, Isma Widiaty, Cep Ubad Abdullah, Medical Technology and Environmental Health, 2020
H.A. Wisnuwardhani, R.D. Shafira, Y. Lukmayani, A. Arumsari
The development of the emergence of microbial resistance to a particular antimicrobial, making the discovery of a new drug (antimicrobial) that has a broad spectrum is very important. Copper nanoparticles are one of the most widely studied metal nanoparticles as a promising antimicrobial candidate besides silver nanoparticles. Copper nanoparticles themselves have been widely studied as antibacterial against bacteria E. coli and S. aureus (Prabhu et al. 2017), E. coli (Lee et al. 2013, Chatterjee et al. 2014). Synthesis of metal nanoparticles using plant extracts as bioreductors, most of which are still focused on the synthesis of silver nanoparticles, which are already widely studied as having antibacterial activity. One of the studies on the synthesis of copper nanoparticles using plant extracts is the synthesis of copper nanoparticles using clove flower extract (Syzigium aromaticum) (Rengga et al. 2017), and even then, not to test its antibacterial activity. Other researchers are mostly from abroad, including using Nag Champa (Kathad & Gajera, 2014), mangos teen leaves (Prabhu et al. 2017), tea leaves (Mandaya, et al. 2017), Magnolia Kobus (Lee et al. 2013) leaves, Asparagus adscendens leaves (Thakur et al. 2018), Citrus medica fruit (Shende et al. 2015). According to previous research, there are no studies that have carried out the synthesis of copper nanoparticles using extracts.
Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model
Published in Nanotoxicology, 2022
Vanrohlu Nicy, Milirani Das, Guruswami Gurusubramanian, Pradip Mondal, Vikas Kumar Roy
It has been shown that nanoparticle, including CuNPs, induces a toxic effect via increasing oxidative stress and also induces inflammation (Tang et al. 2018; Xu et al. 2022; Tang et al. 2018; Zhou et al. 2019; Wang et al. 2019). In general, copper nanoparticles and copper have been reported to exhibit toxic effects leading to cell death, when copper intake exceeds the tolerable limit (Hejazy et al. 2018). Furthermore, nano-copper caused placental damage by inducing inflammation and autophagy and affects fetal growth and development (Kang et al. 2021; Luo et al. 2020). It was also well known that increased oxidative stress in testis, impaired germ cell proliferation, stimulated apoptosis and decreased testosterone biosynthesis. However, the effects of CuNPs have not been investigated on these parameters after the CuNPs treatment.
Therapeutic prospective of plant-induced silver nanoparticles: application as antimicrobial and anticancer agent
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Krushna C. Hembram, Rahul Kumar, Laxman Kandha, Pankaj K. Parhi, Chanakya N. Kundu, Birendra K. Bindhani
Plant extracts were widely used in the formation of various metallic nanoparticles apart from silver and gold for various other important uses. Polladium nanoparticles (PdNPs) were used as catalyst in different reactions. PdNPs were synthesized using the plant extract of Hippophae rhamnoides and Catharanthus roseus leaf extracts shows catalytic activity in Suzuki miyaura coupling reaction in water and photo-catalytic degradation. Plant mediated some other metallic nanoparticle includes copper nanoparticles (CuNPs) formed by using Citrus medica Linn juice showed antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Propionibacterium acnes, Salmonella typhi and Pseudomonas aeruginosa. These above studies give clear idea about the applicability, advantages and broad aspect of plants in the field of nanotechnology [5,6]. In medicines, silver and silver nanoparticles were used as an ointment to overcome against burn and wound infection. Silver nanoparticles have been reported as having the highest electrical and thermal conductivity than any metal. They have extra ordinary properties like chemical stability, high conductivity and induce both catalytic and biological activities. These unique properties of silver force the researcher to consider over the other metallic nanoparticles for antimicrobial, antiviral, anticancer, antifungal and anti-inflammatory activities. It has been investigated and recognized that it has an ability to inhibit microbial growth present in medical and industrial processes.
Green synthesis of copper nanoparticles using Cissus vitiginea and its antioxidant and antibacterial activity against urinary tract infection pathogens
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Shuang Wu, Shanmugam Rajeshkumar, Malini Madasamy, Vanaja Mahendran
Now a day non-conventional antioxidant and antibacterial agents are becoming key in the pharmaceutical research field. The results of antibacterial action of spherical shaped nano copper treated against UTI pathogens, namely E.coli, Enterococcus sp., Proteus sp. and Klebsiella sp. and the zone of inhibition around the copper nanparticles loaded disc was noted and measured (Figure 7). From our results, we observed that copper nanoparticles highly active against E. coli and Enterococcus sp. it shows the high zone of inhibition around 22.2 and 20.3 mm in diameter, respectively. Klebsiella sp. exhibit moderately inhibition (18.5 mm) whereas Proteus sp. exhibit less sensitivity (16.33 mm) to copper nanoparticles. Likewise, Ruparehia et al. [30] reported that E. coli showed higher sensitivity to nano copper. It was the strains of E. coli and Enterococcus sp. was the more resistant microorganisms being higher than 80 and 70%, respectively. This nano copper appears to push its killing effect by introducing reactive hydroxyl radicals that can cause irrespirable damage such as the oxidation of proteins, separation of RNA and DNA molecules and cell membrane mutilation due to lipid peroxidation. Similarly, Sivaraj et al. [31] proved that Tabernaemontana divaricate leaves mediated synthesized copper oxide nanoparticles were very effective nanomaterials against UTI pathogen especially E. coli. The nano copper proved that forcible inhibits the growth of UTI pathogens namely E. coli, Enterococcus sp., Proteus sp. and Klebsiella sp.