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Unlocking scaffold mechanical properties
Published in Yoshinobu Onuma, Patrick W.J.C. Serruys, Bioresorbable Scaffolds, 2017
John J. Scanlon, Yoshinobu Onuma, Patrick W.J.C. Serruys, Joseph M. Deitzel
The current coronary bioresorbable scaffolds (BRSs) are composed of either an aliphatic polymer or bioresorbable metal alloy. Numerous different polymers are available, each with different chemical compositions, mechanical properties, and subsequent bioresorption times. The purpose of this chapter is to facilitate the understanding of mechanical features of the materials used for bioresorbable scaffolds.
Coronary artery stenting
Published in Debabrata Mukherjee, Eric R. Bates, Marco Roffi, Richard A. Lange, David J. Moliterno, Nadia M. Whitehead, Cardiovascular Catheterization and Intervention, 2017
Raffaele Piccolo, Stephan Windecker
Current BRS are made of either a polymer or bioresorbable metal alloy. The scaffold composition is of great importance as it entails different chemical compositions, mechanical properties, and subsequent resorption times. The two most frequently used materials in the current generation of BRS are PLLA and magnesium.
Microneedles as an alternative technology for transdermal drug delivery systems: a patent review
Published in Expert Opinion on Therapeutic Patents, 2020
Monna Lisa Barreto Queiroz, Saravanan Shanmugam, Lana Naiadhy Silva Santos, Caio de Alcântara Campos, Anamaria Mendonça Santos, Mayrton Santos Batista, Adriano Antunes de Souza Araújo, Mairim Russo Serafini
Evonik Corporation and Kevin Burton [45] (2019), proposed a microneedle array that includes a system of delivering to the skin for a period of time for a treatment period. The microneedle also included a coating, such as a lubricious coating for ease of penetrating of anti-microbial agents in the skin. Therefore, the microneedles could be fabricated from bioresorbable metal or a biodegradable, the microneedles are comprised of a nonresorbable metal or a resorbable or nonresorbable polymer material. Thus, the drug delivery system has a plurality of rigid or flexible microneedles array. However, in certain locations of the microneedle a swellable portion is formed in the polymer structure and the swellable portion also comprises material such as polymethlmethacrylate, polyethylene glycol, hydrogels, and superabsorbers.