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Flaxseed and L-Arginine, and Omega-3 Fatty Acids, per se, in Treatment of Hypertension and Sickle Cell Disease
Published in Robert Fried, Richard M. Carlton, Flaxseed, 2023
Robert Fried, Richard M. Carlton
The Journal of Chiropractic Medicine published an “umbrella review,” i.e., a review of previously published systematic reviews or meta-analyses that encompassed the literature from January 1, 1980, through December 31, 2015, of three separate databases—PubMed, Cochrane Library and Cumulative Index to Nursing and Allied Health Literature.
Animal healers
Published in Clive R. Hollin, An Introduction to Human–Animal Relationships, 2021
Santaniello et al. (2020) conducted an “umbrella review” summarising the methodological issues highlighted in 15 systematic reviews of AAT. They found variations in descriptions of therapeutic parameters such as number and length of sessions and the duration of treatment, while there was little the uniformity in the descriptions of the intervention. There was also disparity in the research methodology applied to study outcome.
Advanced approaches to evidence synthesis and its application to intervention design
Published in David A. Richards, Ingalill Rahm Hallberg, Complex Interventions in Health, 2015
By the end of this chapter and associated reading you should be able to: Understand how subgroup analysis and meta-regression of primary studies (randomized controlled trials, or RCTs) may be used to understand heterogeneity and design new complex interventions.Understand the differences between study-level meta-analysis and IPD meta-analysis and identify where IPD meta-analysis may be beneficial.Understand how network meta-analysis can be used to determine the relative effectiveness of interventions that have not been compared in head-to-head comparisons.Describe the difference between a traditional systematic review and an umbrella review or overview.
Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies
Published in Nutrition and Cancer, 2023
Junhao Chen, Kaimin Ke, Zhenghuan Liu, Luchen Yang, Linchun Wang, Jing Zhou, Qiang Dong
Umbrella review has become increasingly popular, especially in the last 2 years, and it has been regarded as one of highest levels of evidence synthesis because it includes meta-analyses with a relatively large number of subjects. To the best of our knowledge, this study is the first umbrella review investigating BMI and cancer risk. However, there were also several limitations. First of all, the studies included in the meta-analyses of our umbrella review were mainly cohort and case-control studies and lacked experimental studies, which will have an impact on the overall quality of the study. Second, this umbrella review was a comprehensive evaluation of existing systematic reviews and meta-analyses about BMI and cancer risk. Consequently, some related studies that have not been published before our search will not be included in this study. Third, among the 42 meta-analyses, five meta-analyses reported significant publication bias, and the data about publication bias were not available for 10 meta-analyses. Last but not least, the risk of tumor occurrence is the result of many factors, which might exert an impact on associations between BMI and cancer incidence.
Digital and blended curriculum delivery in health professions education: an umbrella review with implications for Doctor of Physical Therapy education programs
Published in Physical Therapy Reviews, 2022
Megan A. Connelly Ortega, Victoria G. Marchese, Michael J. Zarro, Roy J. Film, Andrea G. Shipper, Cara Felter
There are structured methods to explore the literature such as systematic and umbrella reviews. A systematic review is typically narrow in its focus examining a single intervention or paradigm, while an umbrella review encompasses multiple interventions or paradigms [9]. An umbrella review is a review of published systematic reviews that includes a comparison of findings, provides an overall summary of the available evidence on a topic, and shows whether reviewers of similar topics have come to similar or different conclusions [9]. More than 10,000 systematic reviews have been published on the topic of curriculum design and delivery in HPE. These reviews mostly focused on a single method of curriculum delivery (e.g. the flipped classroom approach) [10–13] and/or a limited learning objective (e.g. anatomy education) [14–16]. Therefore, to implement the best practices throughout a program’s entire curriculum, it is necessary to look broadly at all of the available research on curriculum design and delivery to adopt the most salient and efficacious practices.
Tea intake and cardiovascular disease: an umbrella review
Published in Annals of Medicine, 2021
Abby Keller, Taylor C. Wallace
Our umbrella review has several strengths and limitations. Quality assessment of the included systematic reviews by AMSTAR 2 is a major strength. Our umbrella review is limited due to the reliance on previously published systematic reviews, leaving the opportunity that missed studies may have an influence on our findings. To circumvent this dilemma, we included all (not just the most recent) systematic reviews within the past 10 years and made judgements based on the consistency of evidence over time. There is known overlap between studies included amongst similar systematic reviews; however, consistency of the results reported by different researchers analysing similar data reduces the chance of confirmation bias. As previously stated, the small sample sizes present in many meta-analyses within included systematic reviews may also be a limiting factor for detecting more modest effects of tea. Additional large, randomised intervention studies of both healthy and at-risk populations assessing the effects of beverage tea intake on CVD outcomes and biomarkers can help increase the evidence supporting our reported effects.