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Analysis of Repeated Measures Data
Published in K. V. S. Sarma, R. Vishnu Vardhan, Multivariate Statistics Made Simple, 2018
K. V. S. Sarma, R. Vishnu Vardhan
MedCalc is another software used by clinical researchers for statistical analysis. We can open an SPSS file in this software and run the analysis. The menu sequence for RM ANOVA is Statistics ANOVA Repeated measures Analysis of Variance. We have to select thee variables in the order QOL_1, QOL_2 and QOL_3. Since there is no factor for grouping the records, we can press OK. The output of MedCalc is shown in Figure 5.3.
Computer-Aided Diagnosis of Prostate Magnetic Resonance Imaging
Published in Ayman El-Baz, Gyan Pareek, Jasjit S. Suri, Prostate Cancer Imaging, 2018
Valentina Giannini, Simone Mazzetti, Filippo Russo, Daniele Regge
Per-patient and per-lesion assessments were compared using McNemar test; other comparisons were performed with Mann-Whitney test. The AUROC was generated for each reader using the confidence scores and pathology results. Statistically significance was set at p ≤ 0.05. Inter-observer agreement between reviewers was evaluated using Fleiss Kappa statistics on StatsToDo© [https://www.statstodo.com/CohenKappa_Pgm.php]. All other tests were conducted using MedCalc version 15.6.1.
The doctor′s bag
Published in Peter Davies, Lindsay Moran, Hussain Gandhi, Adrian Roebuck, Clare J Taylor, The New GP′s Handbook, 2022
The following are some useful apps that can be used in your day-to-day working life: Evernote: a great free notepad app that can be used as a stopgap to your appraisal and revalidation ePortfolio. Great for taking notes, photos and videos to link to your continuing professional development work, Evernote is available on most platforms. If you need higher storage limits these can be obtained for a fee.MIMS: although the British National Formulary app is more well known, the MIMMs app is of equal quality and provides equal depth of information as far as drug guidance apps go, and at nearly a fifth of the cost. This is available on Android and iOS.VisualDX: a great dermatology app that can be used for comparing rashes, or even as a differential diagnosis aid. It is reasonably expensive, although this is less than the cost of a dermatology course. This is available on Android and iOS.Epocrates: a combination of MIMS with a medical calculator. This is free to use though a large download and available on most platforms.Google Translate: not as good as a translator, but it does come close and it is very useful if Language Line is not an option. This is available on Android and iOS and through any internet browser.PocketCPR: a cardiopulmonary resuscitation guidance app offering real-time feedback and an audible metronome. This is available on Android and iOS.Google Navigation: if you have an Android phone please download this app. It is a satnav for your phone and it runs off Google Maps. This app makes finding your way to home visits a doddle.MedCalc: a collection of medical calculator programmes in one app. This is available in iOS.3D Brain: as it sounds, this is a great app to help understand neurology. This is available on iOS.Pillboxie: if your patient has an iPhone, get them to use this app. It helps them to effortlessly remember when to take medications and, more important, it shows them which one to take. This is available on iOS.NHS Direct: the NHS has their own app for information for patients. This is a basic but useful app that gives medical advice.
Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn’s disease: results from an Italian multicenter study
Published in Expert Opinion on Biological Therapy, 2023
Giammarco Mocci, Antonio Tursi, Giovanni Maconi, Giovanni Cataletti, Beatrice Mantia, Mariaelena Serio, Antonella Scarcelli, Cristiano Pagnini, Maria Giovanna Graziani, Maria Carla Di Paolo, Giuseppe Pranzo, Ileana Luppino, Pietro Paese, Walter Elisei, Rita Monterubbianesi, Roberto Faggiani, Antonio Ferronato, Barbara Perini, Edoardo Savarino, Francesca Maria Onidi, Laura Binaghi, Paolo Usai Satta, Elisa Schiavoni, Daniele Napolitano, Franco Scaldaferri, Daniela Pugliese, Roberta Pica, Andrea Cocco, Maddalena Zippi, Stefano Rodino, Ladislava Sebkova, Giulia Rocco, Carlotta Sacchi, Costantino Zampaletta, Federica Gaiani, Gianluigi De Angelis, Stefano Kayali, Libera Fanigliulo, Roberto Lorenzetti, Leonardo Allegretta, Stefano Scorza, Antonio Cuomo, Laura Donnarumma, Nicola Della Valle, Rodolfo Sacco, Giacomo Forti, Elisabetta Antonelli, Gabrio Bassotti, Chiara Iannelli, Francesco Luzza, Giovanni Aragona, Patrizia Perazzo, Angelo Lauria, Simona Piergallini, Raffaele Colucci, Maria Antonia Bianco, Costantino Meucci, Gianmarco Giorgetti, Valeria Clemente, Serafina Fiorella, Antonio Penna, Antonio De Medici, Marcello Picchio, Alfredo Papa
MedCalc® Release 14.8.1 was used to analyze the data. The median (interquartile range [IQR]) for continuous nonparametric variables and as a number (percentage) for a categorical variable were used to examine the characteristics of the study group’s characteristics. The categorical variables were compared using the Chisquare test, and the continuous variables were compared using the Mann–Whitney test. The primary endpoint was considered clinical remission. Because of the varying length of followup, a time to event method for censored observations was used to assess the predictive value of clinical parameters. The duration of followup was calculated from the date of diagnosis to the date of the event or censorship. Time to event analysis was carried out using KaplanMeier estimates to draw the cumulative incidence curves. Pvalues of <0.05 were considered to be statistically significant.
Comparison of performances of infliximab biosimilars CT-P13 versus SB2 in the treatment of inflammatory bowel diseases: a real-life multicenter, observational study in Italy
Published in Expert Opinion on Biological Therapy, 2022
Antonio Tursi, Giammarco Mocci, Leonardo Allegretta, Giovanni Aragona, Maria Antonia Bianco, Raffaele Colucci, Antonio Cuomo, Nicola Della Valle, Antonio Ferronato, Giacomo Forti, Federica Gaiani, Maria Giovanna Graziani, Roberto Lorenzetti, Francesco Luzza, Pietro Paese, Antonio Penna, Roberta Pica, Giuseppe Pranzo, Stefano Rodinò, Antonella Scarcelli, Costantino Zampaletta, Lorenzo Brozzi, Clelia Cicerone, Andrea Cocco, Gianluigi De’ Angelis, Laura Donnarumma, Serafina Fiorella, Chiara Iannelli, Tiziana Larussa, Marco Le Grazie, Ileana Luppino, Costantino Meucci, Roberto FaggianI, Cristiano Pagnini, Patrizia Perazzo, Kryssia Isabel Rodriguez-Castro, Rodolfo Sacco, Ladislava Sebkova, Mariaelena Serio, Alberta De Monti, Marcello Picchio, Daniele Napolitano, Elisa Schiavoni, Laura Turchini, Franco Scaldaferri, Daniela Pugliese, Luisa Guidi, Lucrezia Laterza, Giuseppe Privitera, Marco Pizzoferrato, Loris R. Lopetuso, Alessandro Armuzzi, Walter Elisei, Giovanni Maconi, Alfredo Papa
Data were analyzed using MedCalc® Release 14.8.1. The characteristics of the study group were analyzed as median interquartile range (IQR) for continuous non-parametric variables and as number (percentage) for categorical variables. Chi-square test was used to compare categorical variables; the Mann–Whitney test was used to compare continuous variables. Clinical remission was considered as the primary end-point. The prognostic value of clinical parameters was evaluated using time-to-event methods for censored observations, because of the varying length of follow-up. Follow-up times were calculated from the date of diagnosis to the date of event or censorship. Time-to-event analysis was carried out using Kaplan-Meier estimates to draw the cumulative incidence curves, compared by logrank tests. P-values of <0.05 were considered to be statistically significant.
Effects of Postural Variation on Intra-ocular Pressure: Comparison between Pseudo-exfoliation Glaucoma and Primary Open Angle Glaucoma
Published in Current Eye Research, 2020
Nimrod Dar, Avner Belkin, Shani Pillar, Vadim Sheiman, Ortal F. Tempelhof, Yaniv Barkana, Noa Geffen
For sample size calculations we used the IOP changes reported in a previous study, Ozkok et al.24 This study enrolled 29 patients with POAG and 32 patients with PXFG and reported IOP increase from 16.6 ± 3.4 (POAG) and 14.9 ± 2.7 (PXFG) at the sitting position to 18.3 ± 3.7 and 18.0 ± 3.0, respectively, at the supine position. We defined a minimum clinically significant difference of 1.2 mmHg. We found that a sample size of 29 patients in each group with a 1:1 ratio was required to detect a significant difference with a significance level of 0.05 and a power of 80% using an independent model. Calculations were performed using Medcalc software version 16 (Mariakerke, Belgium).