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Transient Erythroblastopenia of Childhood
Published in Stephen A. Feig, Melvin H. Freedman, Clinical Disorders and Experimental Models of Erythropoietic Failure, 2019
The first series of publications clearly identifying TEC as a distinct entity were reported in 1970 by Lovric1 from Australia and by Wranne2 from Sweden. During the past few years, however, it has become apparent that TEC is one of the most common red blood cell (RBC) aplasias encountered in pediatric practice. The most severe cases reach the attention of pediatricians or hematologists, although many mild cases probably go unrecognized. Moreover, it is perceived by many physicians that the incidence of this disorder is increasing both in the U.S.3 and Europe.4 Because the magnitude of anemia in TEC usually is severe, it is unlikely that this disorder existed previously as an unrecognized entity. It seems much more probable that TEC represents a new clinical problem.
The Treatment of Burns
Published in Howard Green, Therapy with Cultured Cells, 2019
In 2007, the Japan Tissue Engineering Company (J-TEC) in Aichi, Japan, received regulatory approval for cultured epidermal grafts for the treatment of burns (Fig. 16). In Japan, there are 300 cases per year of full thickness burns affecting over 30% of body surface. At present, J-TEC is treating one new patient per week.
Introduction to Anticancer Therapies
Published in Gabriella Fabbrocini, Mario E. Lacouture, Antonella Tosti, Dermatologic Reactions to Cancer Therapies, 2019
Jennifer Wu, Mario E. Lacouture
Toxic erythema of chemotherapy (TEC) describes the overlapping features of skin toxicity induced by chemotherapy through a reproducible nonimmune mediated effect. The clinical characteristics of TEC are erythematous patches or plaques on the axillae and groins, hands, and feet, and, less often, the elbows, knees, and ears, associated with pain, burning, paresthesia, and pruritus. TEC usually appears within days to 3 weeks following the administration of chemotherapeutic agents but may occur late at 2–10 months in patients receiving lower-dose, continuous infusions of 5-fluorouracil (5-FU), or oral agents. Bullae and erosions within the affected area may be seen. The lesions are often self-limited but may recur with readministration of the same agents (4). Hand-foot syndrome (HFS) is a subtype of TEC involving mainly palms and soles (4,5). Chemotherapeutic agents more commonly associated with TEC include cytarabine (AraC), anthracyclines, doxorubicin and pegylated liposomal doxorubicin (PLD), 5-FU, capecitabine (5-FU prodrug), taxanes (docetaxel and paclitaxel), and methotrexate. Bleomycin, busulfan, carmustine, lomustine, cisplatin, carboplatin, clofarabine, cyclophosphamide, ifosfamide, etoposide, gemcitabine, hydroxyurea, melphalan, 6-mercaptopurine, mitoxantrone, tyrosine kinase inhibitors (imatinib, sunitinib), tegafur, thiotepa, and vinorelbine have also been related to TEC.
The differential effects of upadacitinib treatment on skin rashes of four anatomical sites in patients with atopic dermatitis
Published in Journal of Dermatological Treatment, 2023
Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda
Baseline total EASI before treatment significantly correlated with baseline levels of all laboratory parameters (IgE, TARC, LDH, and TEC). Some studies reported positive correlation of IgE with total EASI, consistent with our results (6), while other studies reported no correlations of IgE with total EASI (7), possibly due to the difference of patients’ population, age, sex distribution, or race. Baseline TARC and LDH significantly positively correlated with baseline total EASI and EASIs of four anatomical sites. Relatedly, previous reports suggested that TARC is the most reliable indicator reflecting severity of AD, and that LDH could also act as an indicator of severity (8). Previous reports have shown that TEC correlates with the severity of AD (9). Baseline EASI of individual sites mostly correlated with baseline IgE, TARC, LDH, and TEC except for no correlation between baseline TEC and EASIs of upper or lower limbs. This suggests that the values of IgE, TARC, LDH, and TEC might reflect the long-term control of rash on almost all the anatomical sites.
Efficacy and safety of plasmapheresis without plasma transfusion tandem with chemotherapy to treat multiple myeloma
Published in Hematology, 2022
Yigang Guo, Lulu Zhang, Rongyao Zhang, Meiling Zhou, Xu Chen, Chucheng Wan, Ping Hu, Yuanyuan He, Hua Jiang, Wei Geng, Weixing Zhang, Fariha Kanwal, Muhammad Fayyaz ur Rehman, Zhangzhi Li
Plasma exchange was performed using a Fresenius Com. Tec® blood cell separator (Germany) where 20% human serum albumin (100 mL), blood preservation solution ACD (Anticoagulant Citrate Dextrose, 500 mL), hydroxyethyl starch (500 mL), Ringer's solution (500 mL) and normal saline as exchange fluid (instead of traditional plasma exchange that uses fresh frozen plasma). Plasma exchange volume was 30–40 mL/kg, and each exchange interval was around 24–48 h. Three consecutive plasmaphereses without plasma were performed. Blood pressure, hematocrit, plasma albumin and physical status were evaluated before plasma exchange. Patients with severe anemia were infused with red blood cells to improve anemia. Coagulation function, hemoglobin, plasma albumin, globulin and vital signs (blood pressure, oxygen saturation, respiratory rate, and pulse) were monitored after plasma exchange. Fibrinogen (FIB) was supplemented when FIB was lower than 1.0 g/L. The patients with hypotension and dizziness were supplemented with crystals and colloids (albumin or fresh frozen plasma).
A new mixed-ligand coordination polymer: protective activity on influenza a virus-induced COPD via regulating tlr3 gene expression on alveolar epithelial cells
Published in Drug Development and Industrial Pharmacy, 2021
Youhui Tu, Chao Yang, Xiangwei Zhang
All the ligand and metal salts used in this study were obtained from Jinan Henghua Sci. & Tec. Co. Ltd. (Jinan, China). The other materials utilized in this research were from commercial sources and they were utilized without purification. Carbon, nitrogen, and hydrogen were analyzed with the elemental analytical instrument of Vario MACRO cube. The IR spectrum of KBr pellets in the range of 4000–400 cm−1 was carried out by using the FTIR-8400S Spectrometer. The measurements of powder X-ray diffraction (PXRD) were performed with the diffractometer of Rigaku D/Max-2500 PC in 5–50° 2θ range with radiation of Cu Kα (λ = 0.71073 Å). On the analyzer of ZCT-A at 25–800 °C, the thermogravimetric (TG) analyses were carried out in nitrogen atmosphere with 10 °C min−1 heating rate.