China
Africa
Explore chapters and articles related to this topic
Emerging Potential of In Vitro Diagnostic Devices: Applications and Current Status
Published in Debarshi Kar Mahapatra, Sanjay Kumar Bharti, Medicinal Chemistry with Pharmaceutical Product Development, 2019
Swarnali Das Paul, Gunjan Jeswani
There are many more other applications of IVD. They are including tests for genetic disorder, enzyme screening tests, tests for hematology, tests for metabolism, etc. Tests intended for an inherited or acquired genetic marker, including: detecting the Philadelphia chromosome, prenatal genetic screening tests for Huntington’s disease, cystic fibrosis and many more. IVDs are also helpful in monitoring biological components, including acute cardiac markers such as, Troponin T, Troponin I, and CKMB. Even congenital disorders can be detected by in vitro testing devices. Alpha fetoprotein (AFP) marker for fetal open neural tube defects is detected by IVD. Much software is embedded as a part of IVD. One such example is software for the analysis of results acquired in the first trimester to detecting fetal risk of trisomy. IVDs are also employed for performing coagulation testing, including factor assays, activated partial thromboplastin time (APTT) and prothrombin time testing. IVDs are also intended for therapeutic checking of the impact of incorrect use of immunosuppressive drugs such as, tacrolimus and cyclosporin, and for detecting their adverse transplantation consequence.
Seventeenth-century English surgery: the casebook of Joseph Binns
Published in Christopher Lawrence, Medical Theory, Surgical Practice, 2018
Not all surgical repairs of congenital disorders presented such problems. Binns reported that ‘Mr. Webster of Chesterfield his son was cut of a wry neck the 19 June 1640. It was skinned in 5 days. (Mr. Harris his way of cutting)’.63 Binns made no suggestion that such an operation was either dangerous or unusual. However, Mr Webster was concerned enough to travel a long way in search of expert surgical help. He was not alone. London was used as a medical centre for the whole of England, and Binns’s patients had often travelled long distances to consult him.
The role of complementary and integrative medicine within preconception care
Published in Jon Adams, Amie Steel, Alex Broom, Jane Frawley, Women’s Health and Complementary and Integrative Medicine, 2018
Abigail Aiyepola, Amie Steel, Jane Frawley, Jon Adams
Preconception care has received increased attention due to growing evidence that maternal health prior to conception can directly affect the health of the mother and the fetal environment during pregnancy (Committee on Gynecologic Practice, 2005). The majority of research attention in this area over the last 20 years has been directed towards the benefits of folic acid supplementation in preventing birth defects (Berry et al., 1999; Boyles et al., 2011; Khodr et al., 2014; Wilson et al., 2003; Yi et al., 2011). Meanwhile, the broader preconception care research field emphasises the impact of the fetal environment on adverse outcomes such as miscarriage (Nielsen et al., 2006), stillbirth (Signorello et al., 2010), congenital disorders (Shannon et al., 2013) and macrosomia (Strutz et al., 2012).
Modic changes and its association with other MRI phenotypes in east Anatolian low back pain patients
Published in British Journal of Neurosurgery, 2022
Low back pain (LBP) is an important global health problem and one of the leading causes of labor loss owing to limitations experienced by patients in performing activities of daily living.1,2 LBP is defined as pain, muscle tension, stiffness, and limitation of movement in the area between the 12th costal lower border and the lower gluteal folds. The cause of LBP has been identified in 5–10% of all cases. Common causes include trauma, congenital disorder, systemic disease, inflammation, infection, neoplasm, and issues related to metabolism.3 However, in many cases, it is difficult to establish a specific diagnosis. Pain and disability are the most important symptoms associated with nonspecific back pain. Despite the high prevalence of LBP, its pathophysiology has not been completely elucidated to date.
Antenatal corticosteroids-to-birth interval in preterm birth
Published in Acta Clinica Belgica, 2021
Isabelle Dehaene, Kris De Coen, Anna Oostra, Johan Decruyenaere, Kristien Roelens, Koenraad Smets
The observational data originates from the preterm birth register of Ghent University Hospital, a referral center for high-risk obstetric patients in Belgium. The register was created in 2016 and includes all women who delivered from 24 + 0 to 33 + 6 weeks’ gestation. Patients with the diagnosis of intrauterine fetal death at admission or expecting a fetus with a major congenital disorder that could influence neonatal outcomes were not included since the main goal of the registry is to explore neonatal and long-term outcomes according to obstetrical management. Maternal data was obtained retrospectively from 2012 till 9 July, 2017. From 10 July, 2017, data was collected prospectively, after obtaining informed consent of the parents to be. Neonatal data was extracted from the already operational neonatal database and imported into the register. Patient involvement was limited to consenting in the registration of the data and using the data for scientific purposes. Based on the current literature, a set of important variables was collected and managed using REDCap (Research Electronic Data Capture), a secure, web-based application designed to support data capture for research studies [10]. Of the core outcome set for evaluation of interventions to prevent preterm birth, all but one core neonatal outcomes were included in the register (not included is harm from intervention). Only one of the four core maternal outcome was included (PPROM) [11]. No other core outcome sets on PTB are available.
The safety of metronidazole in pregnancy
Published in Health Care for Women International, 2021
Ozioma C. Nwosu, Kathaleen Bloom
On February 2, 2018, a search of PubMed and ProQuest was conducted using “peer review” and “English” as limiters. Keyword, Boolean and MeSH searching included the following terms: Newborn OR Infant OR Neonate OR Fetus (Line 1) AND, Maternal OR Mother OR pregna* (line 2) AND, Metronidazole OR Flagyl (line 3) AND, Congenital abnormality OR Congenital Anomaly OR Congenital disorder OR Fetal anomaly OR fetal defect (line 4). Only 3 articles were ultimately selected for inclusion in the review. One of the articles was a systematic review (Sheehy et al., 2015). A replication of their search strategies failed to uncover any studies that were not previously analyzed. Two articles by Muanda and colleagues were found by a third party. One of these articles (Muanda et al., 2017) addressed the link between antibiotic use during pregnancy and the risk of spontaneous abortion. The other addressed the link between antibiotic use in pregnancy and the risk of major congenital malformations. However, metronidazole was not one of the antibiotics considered so this study was excluded. Figure 1 depicts the flow of the search.