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Renal disorders
Published in Rachel U Sidwell, Mike A Thomson, Concise Paediatrics, 2020
Rachel U Sidwell, Mike A Thomson
A similar condition often confused with Bartter syndrome, involving hypomagnesaemia, hypokalaemia and hypo-calciuria, with normal growth. Caused by a defect in thiazide-sensitive NaCl channels in the distal tubule. Treatment includes magnesium supplements.
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Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Bartter Syndrome Diminished sodium resorption by the proximal tubule of the kidney leading to hypokalemic alkalosis. Described by American physician, Frederick C. Bartter (1914–1985) and colleagues in 1958. He was born in Manila in the Philippines and graduated from Harvard in 1940. Inappropriate secretion of antidiuretic hormone in patients with bronchial carcinoma was described by him and W.B. Schwartz in 1957.
Section 3
Published in Padmanabhan Ramnarayan, MCQs in Paediatrics for the MRCPCH, Part 1, 2017
Metabolic alkalosis with hypokalaemia is seen in pyloric stenosis because of the loss of stomach acid with K+ and HCl, and cystic fibrosis as in pseudo-Bartter syndrome. Bartter syndrome is a form of renal potassium wasting with elevated renin and aldosterone; the K+ is usually (2.5mmol/l. Renal failure and urinary diversion procedures cause metabolic acidosis.
Severe hypokalemia with cardiac arrest as an unusual manifestation of alcoholism
Published in Journal of Community Hospital Internal Medicine Perspectives, 2018
Omar Abdulfattah, Ebad Ur Rahman, Zainab Alnafoosi, Frances Schmidt
renal tubular acidosis, diabetic ketoacidosis, Bartter syndrome and Gitelman syndrome unlikely. Renal artery stenosis, malignant hypertension, renin-secreting tumor, and hyperaldosteronism were ruled out as active renin level was 0.653 ng/ml/hr (reference 0.167−5.38 ng/ml/hr) and aldosterone levels was < 0.01 ng/dL (reference 0.00− 30 ng/dL). Gastrointestinal potassium loss was ruled out as patient had no history of diarrhea, vomiting or acid-base disturbance (pH was 7.430). Twenty-four-hour stool collection for potassium level was ordered but test could not be performed as stool was solid and the test can only be utilized on liquid stool. Based on clinical and laboratory testing results we concluded that hypokalemia was secondary to chronic alcohol-use disorder.
The patient with metabolic alkalosis
Published in Acta Clinica Belgica, 2019
Valentine Gillion, Michel Jadoul, Olivier Devuyst, Jean-Michel Pochet
Bartter syndrome refers to a group of recessive tubulopathies with impaired salt reabsorption in the thick ascending loop of Henle with an important subsequent salt wasting, metabolic alkalosis with hypokalemia and hypercalciuria. Gitelman syndrome is a milder tubular disorder with a usual adult onset. Bi-allelic mutations in the thiazide-sensitive Na-Cl cotransporter of the distal convoluted tubule result in renal tubular salt-wasting disorder with hypokalemic metabolic alkalosis, hypocalciuria and hypomagnesemia. These salt-losing conditions lead to hypovolemia and secondary hyperaldosteronism
A step towards precision medicine in management of severe transient polyhydramnios: MAGED2 variant
Published in Journal of Obstetrics and Gynaecology, 2019
Chloé J. Arthuis, Mathilde Nizon, Martin Kömhoff, Bodo B. Beck, Vera Riehmer, Tiphaine Bihouée, Alexandra Bruel, Nadir Benbrik, Norbert Winer, Bertrand Isidor
Transient antenatal Bartter syndrome is an X-linked recessive disorder (Xp11.21). Until known, all women are asymptomatic carriers. Genetic counselling has to be offered to those couples to explain the risk of recurrence for a male foetus, the usually favourable outcome, but also the risk of perinatal death mainly due to a prematurity. Therefore, they should be informed of the importance of a close monitoring to prevent a prematurity with iterative amnioreductions. Moreover, a treatment with indomethacin may be discussed.