Puumala orthohantavirus

Order Bunyavirales

Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022

Paul Pumpens, Peter Pushko, Philippe Le Mercier

The crystal structure of the ectodomain Gn of Puumala hantavirus (PUUV) of the Puumala orthohantavirus species, genus Orthohantavirus, subfamily Mammantavirinae, expressed in mammalian cells was determined to 2.3 Å resolution using the single-wavelength anomalous diffraction method (Li S et al. 2016). Furthermore, using electron cryotomography of related apathogenic Tula orthohantavirus (TULV), the structure of the envelope glycoprotein spike complex was resolved to 16 Å (Li S et al. 2016).

Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies

View Article

Journal Information

Published in Infectious Diseases, 2022

Anne Tuiskunen Bäck, Johan Rasmuson, Therese Thunberg, Gregory Rankin, Julia Wigren Byström, Charlotta Andersson, Andreas Sjödin, Mattias Forsell, Clas Ahlm

Puumala orthohantavirus (PUUV) is endemic in the Central and Northern Europe with a peak incidence of >300 cases per 100,000 inhabitants with an overall case-fatality rate of 0.4%, and 2–6% for elderly patients [3]. The symptoms include fever, headache, myalgia, abdominal pain, blurred vision and oliguria [1]. Thrombocytopenia and renal impairment are frequent and diagnostic for the disease. One third of diagnosed patients are hospitalised and may develop hypotension due to capillary leakage [4].

Puumala orthohantavirus

Explore chapters and articles related to this topic

Order Bunyavirales

Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies