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Benzylpenicillin (Penicillin G)
Published in M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson, Kucers’ The Use of Antibiotics, 2017
Alasdair M. Geddes, Ian M. Gould, Jason A. Roberts, Jason A. Trubiano, M. Lindsay Grayson
The uncommon enterococcal species E. avium and E. raffinosus have different Pen G susceptibilities. The MIC range for the former is 0.5–2 μg/ml, and for the latter, 4–64 μg/ml. Enterococcus raffinosus appears to have a PBP7, which is a low-affinity PBP, and this may play a role in the relative Pen G resistance of this species (Grayson et al., 1991b; Patel et al., 1993).
Intravenous fosfomycin for the treatment of patients with central nervous system infections: evaluation of the published evidence
Published in Expert Review of Anti-infective Therapy, 2020
Katerina G Tsegka, Georgios L Voulgaris, Margarita Kyriakidou, Matthew E Falagas
In more than 73 patients, the microbial agent that was isolated was Staphylococcus [Staphylococcus aureus, Staphylococcus epidermidis, including MRSA (n = 12) and MRSE (n = 2)]. The rest of the pathogens isolated are analyzed as follows: 22 cases of Streptococcus pneumoniae meningitis, 12 cases of Neisseria meningitidis, 7 cases of Escherichia coli, 6 cases of Haemophilus influenzae, 2 cases of Bacteroides, 2 ESBL Klebsiella pneumoniae, 2 cases of Acinetobacter baumannii. In addition, several other microorganisms were reported in case reports, including Bacillus cereus, Campylobacter fetus subsp., Citrobacter koseri, extensively drug resistant Pseudomonas aeruginosa (XDR-PA), Aspergillus fumigatus, Enterococcus raffinosus, Serratia marcescens. There were some cases of meningitis, in which the pathogen was not isolated.
Etiology, drug sensitivity profiles and clinical outcome of bloodstream infections: A retrospective study of 784 pediatric patients with hematological and neoplastic diseases
Published in Pediatric Hematology and Oncology, 2019
Senmin Chen, Sixi Liu, Xiuli Yuan, Huirong Mai, Junrong Lin, Feiqiu Wen
Five thousand one hundred and sixty-two blood samples were collected during the 2-year study. A total of 295 organisms (42 types) were isolated, and 5.7% of blood cultures were positive. Thirty-nine cases with Gram-positive bacteria were isolated, including CoNS (n = 28), Staphylococcus aureus (n = 1), Streptococcus mitis (n = 8), Rothia mugilacinosa (n = 1), and Enterococcus raffinosus (n = 1).