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Interstitial Lung disease In Childhood Rheumatic Disorders
Published in Lourdes R. Laraya-Cuasay, Walter T. Hughes, Interstitial Lung Diseases in Children, 2019
Respiratory symptoms and pulmonary radiographic abnormalities of SS may regress following treatment with corticosteroids, if treatment is begun early in the course of disease. Failure to respond to therapy suggests the presence of fibrosis or a more advanced lesion. Pseudolymphoma, characterized by infiltrates of mature lymphocytes with true germinal centers, but without histologic criteria for malignancy, may also respond to therapy with corticosteroids or immunosuppressive agents. In other cases pseudolymphoma may progress to malignant lymphoma. A marked decrease in previously elevated IgM level may herald the development of a malignancy.38
Skin diseases of the elderly
Published in Robert A. Norman, Geriatric Dermatology, 2020
Actinic reticuloid dermatitis is a photosensitivity disorder associated with exaggerated response to UVA or UVB and even visible light. Some patients have a history of contact allergy to oleoresin extracts of common fragrances and composite plants. Clinically, the patients have lichenified erythematosus plaques of the forehead and neck which can progress to create a leonine facies (Figure 19). The itching is very intense. It has been described as a pseudolymphoma, but there are reports of a transition to malignant lymphoma. The histopathologic infiltrate is predominately T-cell suppressor cells (OKT8).
Descriptions of important reactions
Published in Jerome Z. Litt, Neil H. Shear, Litt's Drug Eruption & Reaction Manual, 2017
Pseudolymphoma is not a specific disease. It is an inflammatory response to various stimuli – known or unknown – that results in a lymphomatous-appearing, but benign, accumulation of inflammatory cells. It may resemble true lymphoma clinically and histologically. Localized, nodular pseudolymphomas typically mimic B-cell lymphoma.
Cutaneous B-Cell Pseudolymphoma (Lymphocytoma Cutis) of the Earlobe: A Poorly Recognized Complication of Ear Piercing in Children
Published in Fetal and Pediatric Pathology, 2022
Jonathan C Slack, Kyle C Kurek, Frankie O G Fraulin, Marie-Anne Brundler
Histologic sections demonstrated similar features to those seen in case 1. There was a dermal-based nodular infiltrate in the richly-vascularized dermis surrounding a squamous-lined sinus tract, consisting of plasma cells without light chain restriction (CD79a, Kappa, Lambda), mast cells, histiocytes (CD68), eosinophils, and small lymphocytes, with primary and secondary lymphoid follicles admixed throughout, and sparing of the overlying epidermis. The small, interfollicular lymphocytes were mostly B-cells (CD20, PAX-5), with lesser numbers of T-cells admixed (CD3, CD5, CD4 or CD8). The reactive lymphoid follicles (CD20, PAX-5, BCL-6+ and BCL-2 negative) demonstrated preserved follicular dendritic cell networks (CD21). Scattered CD20+/CD30+ centro/immunoblasts were present. No atypical CD30+ cells, or B-cells with aberrant CD5 expression, were identified. The histological and immunophenotypic findings were most in keeping with a B-cell pseudolymphoma. Occasional clusters of foreign-body type giant cells (not containing polarizable material) were identified. There was no evidence of a keloid scar.