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Principles of Clinical Diagnosis
Published in Susan Bayliss Mallory, Alanna Bree, Peggy Chern, Illustrated Manual of Pediatric Dermatology, 2005
Susan Bayliss Mallory, Alanna Bree, Peggy Chern
Romani J, Puig L, Fernandez-Figueras MT, de Moragas JM. Pityriasis lichenoides in children: clinicopathologic review of 22 patients. Pediatr Dermatol 1998; 15: 11–16 Lymphomatoid papulosis
Primary cutaneous anaplastic large-cell lymphoma of the eyelid: report of two cases and review of the literature
Published in Orbit, 2021
Adriana Iuliano, Federica Fossataro, Maria Paola Laezza, Vittoria Lanni, Massimo Mascolo, Silvia Varricchio, Giovanni Uccello, Fausto Tranfa, Diego Strianese
Primary cutaneous CD30+ anaplastic large-cell lymphoma (cALCL) is an uncommon T-cell lymphoma, characterised by a good prognosis and responsiveness to treatment.1 This tumour is part of the CD30 + T-cell lymphoproliferative subgroup of disorders that includes lymphomatoid papulosis (LyP); primary cutaneous anaplastic or non-anaplastic CD30+ large-cell lymphoma (cALCL); and aggressive systemic anaplastic large-cell lymphoma (ALCL).2 ALCL usually occurs on the trunk or limbs and presents as solitary, asymptomatic lesions that are nodular, reddish-purple coloured, and often ulcerated. Primary cutaneous involvement of the ocular adnexa is, however, extremely rare.3–8 The tumour often masquerades as basal cell carcinoma, squamous cell carcinoma, or keratoacanthoma, or any tumour that presents as a solitary nodule. Coupled with its rarity, this may result in delayed diagnosis.9–12
New nonchemotherapy treatment options for cutaneous T-cell lymphomas
Published in Expert Review of Anticancer Therapy, 2021
Another group of cutaneous lymphomas are the primary cutaneous CD30+ lymphoproliferative disorders (LPDs), which include lymphomatoid papulosis (LyP) and cutaneous anaplastic large-cell lymphoma (c-ALCL)[3]. LyP is characterized by chronically reoccurring, self-healing skin lesions[10]. While LyP is considered a benign condition, surveillance is recommended due to the risk of evolution to a cutaneous anaplastic large cell lymphoma (c-ALCL) or MF. Patients with c-ALCL present with solitary or local groups of nodules or tumors with or without regional nodal involvement but with no systemic disease. C-ALCL has a favorable prognosis and is often treated with involved field radiotherapy. Patients can have clinical features of both LyP and c-ALCL, and LyP can overlap with mycosis fungoides. In addition, patients with tumor stage mycosis fungoides may demonstrate large cell transformation resembling c-ALCL, so diagnosis often requires understanding of the context of the lesions over time.
Small molecule inhibitors for cutaneous T-cell lymphomas
Published in Expert Opinion on Orphan Drugs, 2018
Cutaneous T-cell lymphomas (CTCLs) are a group of non-Hodgkin’s T-cell lymphomas showing a wide variety of clinical, histopathological, and immunohistochemical findings [1]. Mycosis fungoides, primary cutaneous CD30+ lymphoproliferative disorders, and Sezary syndrome are the most common subtypes of CTCLs [2,3]. Mycosis fungoides represents nearly 50% of all primary CTCLs. In the initial stages, mycosis fungoides presents as slowly progressing erythematous, round, oval, or arciform patches/plaques and its clinical course is generally considered indolent. In about 30% of patients, mycosis fungoides is characterized by an aggressive clinical behavior with multiple nodular/tumor lesions and extracutaneous spread. Sezary syndrome is a rare and more aggressive subtype of CTCL characterized by a generalized exfoliative erythema with severe pruritus and disseminated disease into the blood and lymph nodes [3]. Primary cutaneous CD30+ lymphoproliferative disorders represent about 25% of all CTCLs and include a spectrum of CD30+ cutaneous lymphomas ranging from primary cutaneous anaplastic large cell lymphoma to lymphomatoid papulosis. Primary cutaneous anaplastic large cell lymphoma presents with solitary or localized nodules, sometimes with ulceration and rarely shows extracutaneous involvement during its clinical course [4]. Lymphomatoid papulosis is characterized by an indolent and self-healing diffuse papulo-nodular eruption, generally involving trunk and extremities [4].