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Malignant disease of the skin
Published in Ronald Marks, Richard Motley, Common Skin Diseases, 2019
In addition to the above declared forms of cutaneous T-cell lymphoma, there are a number of uncommon precursor disorders which were known collectively (and inappropriately) as parapsoriasis. These by no means always progress to T-cell lymphoma, and their true nature is uncertain. In addition, they are not well characterized clinically.
The Histopathology of Eczema
Published in Donald Rudikoff, Steven R. Cohen, Noah Scheinfeld, Atopic Dermatitis and Eczematous Disorders, 2014
Cynthia M. Magro, A. Neil Crowson, Molly E. Dyrsen, Martin C. Mihm
Parapsoriasis has two forms: small-plaque and large-plaque. Although there is some controversy over this issue, it appears that the large-plaque variety is a precursor to patch-stage lesions of mycosis fungoides (Sehgal et al. 2007). The small-plaque variant, alternately termed ‘superficial persistent dermatitis’ or ‘chronic superficial dermatitis,’ rarely if ever progresses to mycosis fungoides. Chronic, superficial, persistent dermatitis or small-plaque parapsoriasis is considered with the spongiotic dermatitides. Typically starting in adulthood, patients manifest erythematous round-to-oval scaly patches 1–2 cm in diameter on the trunk or extremities. With an oval contour, they have the approximate size and shape of fingerprints taken from the distal phalanges and, thus, the alternative appellation for this condition is ‘digitate dermatosis.’ Lesions may be larger on the lower extremities; the face, palms, and soles are typically spared. An older lesion may, when compressed from the sides, show a wrinkling of a fine, cigarette-paper-like scale. Lesions may be more prominent in winter and tend to disappear in the summer.
Papulosquamous Skin Disorders in HIV Infection
Published in Clay J. Cockerell, Antoanella Calame, Cutaneous Manifestations of HIV Disease, 2012
Peter Morrell, Antoanella Calame, Clay J. Cockerell
Parapsoriasis is a term that refers to many different unrelated conditions that are largely of historical interest. However, it is discussed here because it still appears in the literature and may be confusing to clinicians. It has traditionally been categorized into small (SPP) and large (LPP) plaque parapsoriasis but also includes acute and chronic variants of pityriasis lichenoides (107) and even lymphomatoid papulosis (LyP).6,29 SPP is generally synonymous with pityriasis lichenoides chronica (PLC), and LPP with patch stage of mycosis fungoides (MF).6,29 They all appear in a worldwide distribution and in every ethnic group, but males do seem to be disproportionately affected.6,29 There have only been a handful of HIV-associated PLEVA cases reported in the literature.30 Of these, all presented with PLEVA while still having CD4 T cell counts greater than 200 × 106/l.30 This leads researchers to conclude that PLEVA is most likely a marker of early to mid HIV infection.30 HIV-associated PLC is similar.31
The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses
Published in Expert Opinion on Drug Safety, 2020
Hye Jung Park, Jung-Won Park, Sae Hoon Kim, So-Yun Choi, Hee-Kyoo Kim, Chang-Gyu Jung, Min-Suk Yang, Dong Yoon Kang, Min-Kyoung Cho, Hyouk-Soo Kwon, Hye-Ryun Kang, Yong Won Lee
We retrospectively reviewed electronic medical records of the recruited seven DHS participants and eight dapsone-tolerant participants. Among seven DHS participants, six participants were female, and the age range was from 11 to 59 years old. Dapsone was prescribed at a usual dose (50–100 mg/day), and was prescribed to treat the underlying disease of each patient, including contact dermatitis (case no. 1), folliculitis (case no. 2), parapsoriasis (case no. 3), allergic cutaneous vasculitis (case no. 4), IgA bullous dermatosis (case no. 5), acne vulgaris (case no. 6), and prurigo pigmentosa (case no. 7). The latent period ranged from 14 to 42 days. Among the eight dapsone-tolerant participants, six were male, and the age range was from 33 to 69 years old. The duration from medication start to stop varied from 87 to 362 days. Participant no. 14, a dapsone-tolerant subject who took dapsone for 253 days, presented with HLA-B*13 (Table 1).
Healthcare resource utilization, costs of care, and treatment of mycosis fungoides cutaneous T-cell lymphoma patterns in a large managed care population: a retrospective US claims-based analysis
Published in Journal of Dermatological Treatment, 2018
Yuen Tsang, Tao Gu, Gaurav Sharma, Susan Raspa, Bill Drake, Hiangkiat Tan
Cutaneous T-cell lymphoma (CTCL) refers to a group of visible lymphoproliferative malignancies characterized by neoplastic T-lymphocytes in the skin with mycosis fungoides (MF) as the most frequent subtype (1–3). MF-CTCL and a leukemic form, Sezary Syndrome (SS), make up approximately 80% of these relatively rare but potentially devastating cutaneous lymphomas (1,3). MF-CTCL typically occurs in three stages – patch, plaque and tumor. It is not unusual for the patch or early phase to remain at that stage for several years as patchy nonspecific dermatitis on the lower trunk and buttocks. Patches may sometimes be wrinkled and have irregular pigmentation patterns, and pruritus, the urge to scratch, is low or nonexistent at this stage (4). MF-CTCL may be followed by common, indolent inflammatory courses that include different forms of dermatitis or parapsoriasis, often large plaque type and may exist over years or decades as the plaque-stage or patch-stage MF-CTCL (5). When well developed, plaques form the basis of MF-CTCL diagnoses and are accompanied by intense pruritus. When these plaques are found on 10% of the body surface, they are classified as stage IA, and when these legions exceed 10%, they are categorized as IB and have been known to remain at these stages for years or decades without any additional development. In more severe cases, the disease could progress to clinical lymphadenopathy or stage IIA, and in some instances, growth of the plaques results in tumor formation or stage IIB. These processes take many years and even decades to develop, and ulcers are a likely result of tumor formation (2,6,7).
Characteristics of hospitalizations and emergency department visits due to generalized pustular psoriasis in the United States
Published in Current Medical Research and Opinion, 2021
Maya L. Hanna, David Singer, Shaun D. Bender, Wendell C. Valdecantos, Jashin J. Wu
ED visits were more often coded with GPP as the primary diagnosis. GPP was the primary diagnosis in 34% of hospitalizations and 69% of ED visits (Table 1, Figure 1(a and b)). Among the remaining visits where GPP was the first secondary diagnosis, 21% of hospitalizations and 25% of ED visits had a primary diagnosis of another skin condition including cellulitis, rash, dermatitis, or parapsoriasis (Figure 1(a and b)). Diabetes, hypertension, and septicemia were included among other coded primary diagnoses among hospitalizations (Figure 1(a)), while circulatory signs/symptoms and nonspecific chest pain made up the majority of other coded primary diagnoses among ED visits (Figure 1(b)).