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Psoriasis and lichen planus
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
This type of psoriasis is seen in children and young adults usually after acute streptococcal infections of throat. It presents with small lesions of 2 mm–1 cm distributed uniformly throughout the body, but mainly on the trunk, arms, and legs (Figure 9.7). Palms and sole involvement is rare. An elevated antistreptolysin O, streptozyme or anti-DNase B titer is found in nearly half of the patients, indicating a recent streptococcal infection. Resolution occurs within 2–3 months.
Hyperkinetic Movement Disorders
Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020
Morales-Briceno Hugo, Victor S.C. Fung, Annu Aggarwal, Philip Thompson
Blood tests: Blood sugar, electrolytes, hemoglobin.Thyroid function tests for BHC and Allan–Herndon–Dudley syndrome.Uric acid for LNS.Autoantibodies for SLE, APS, CD, and autoimmune encephalitis.Antistreptolysin O and anti-DNase B titers (SC).Serum creatine kinase, acanthocytes (NAc).Alpha-fetoprotein, albumin, cholesterol for AOA1 and AOA2.
Laboratory Diagnostic Tests in the Evaluation of Fever
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
Assays for Anti-DNAse-B are more sensitive and specific in the diagnosis of rheumatic fever than are ASO. A recently introduced latex screening test shows great promise as a rapid and inexpensive screen for the disease.
Unilateral Acute Idiopathic Maculopathy Associated with Streptococcal Pharyngitis, A Case Report
Published in Ocular Immunology and Inflammation, 2022
Clare L. Shute, Usha Chakravarthy, Clara E. McAvoy
Given the temporal relationship between developing a sore throat and experiencing unilateral visual loss, biochemical, hematological, and serological investigations were carried out 2 weeks following initial presentation with acute pharyngitis. Biochemistry showed a CRP of 19.2 (normal range <5 mg/L) and a mild uremia of 9.9 mmol/L (normal range 2.4–7.8 mmol/L). Hematological investigations showed an ESR of 20 mm/hr (normal range 1–12 mm/hr) and a WCC of 4.7 x109/L (normal range 4–10 x109/L). Serological investigations revealed a raised anti-streptolysin titer (ASOT) at 800 IU/ml and Streptococcus Anti-DNAse-B (ADB) antibody at 400 U/ml (ASOT > 200 IU/ml and ADB > 200 U/ml are suggestive of current/recent infection according to local laboratory protocol). The anti-streptolysin titer remained raised at 800 IU/ml 2 months later.
Post-Streptococcal Uveitis: Case Report
Published in Ocular Immunology and Inflammation, 2019
Carlos Augusto Medina, Angela Fajardo, Ana Calderon, Manuel Aracena
The diagnosis is mainly clinical, but should be supported by complementary tests, especially serological tests. Before a bilateral, non-granulomatous uveitis appearing after a process of pharyngotonsillitis in a patient under 60 years, this disease should be suspected. The most useful test is the determination of ASO antibodies, which have a high count in all clinical cases reported to date, and the higher they are, the greater the severity of the disease.2 A value >200 U/I has a sensitivity of 85%. False positive results can be obtained by contamination during sample transport and in patients with advanced liver disease. Another diagnostic support which can be obtained is the measurement of anti-deoxyribonuclease B (anti-DNase-B) antibodies. The test combination of ASO and anti-DNase-B has a sensitivity of 95.5% and specificity of 88.6%.2 Pharyngeal cultures are not very useful in patients with streptococcal auto-immune diseases, since they tend to be negative at 2–3 weeks after acute infection.3
Orbital Inflammatory Syndrome Post Group A Streptococcal Infection — Case Series and Review of Literature
Published in Ocular Immunology and Inflammation, 2019
Gilad Rabina, Igal Leibovitch, Muhammad Abumanhal, Amir Rosenblatt, Ran Ben Cnaan
Group A beta-hemolytic streptococci (GAS), also known as Streptococcus pyogenes, is a gram-positive coccus that demonstrates beta hemolysis on blood agar. GAS is thought to be responsible for numerous infections and infection-related syndromes.5 Post-streptococcal immune-mediated sequelae is caused by several immune mechanisms such as antibody-directed molecular mimicry and possible super antigen stimulation of T cells.6 Anti-streptolysin O (ASLO) and anti-DNAse B antibodies levels are the most consistently studied streptococcal antibodies and usually help to support a diagnosis of a post-streptococcal syndrome. ASLO levels have significance if elevated >200 IU/ml.7 Post-streptococcal myalgia/myositis is a rare manifestation and can occur anywhere from several weeks to several months after group A streptococcal (GAS) infection.8