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Pull Test and Trichogram
Published in Rubina Alves, Ramon Grimalt, Techniques in the Evaluation and Management of Hair Diseases, 2021
Cristina Serrano Falcon, Nelly Espinoza, Daniela Guzman
In the questionnaire, we ask about the family history of alopecia; which is particularly useful in androgenetic alopecia (AGA) in which case polygenic inheritance has been demonstrated in its pathogenesis, and if any hair dystrophy with both dominant and recessive inheritance patterns is suspected. Also, it is important to inquire about family and personal history of autoimmune diseases, due to its association with alopecia areata, frontal fibrosing alopecia, and dissecting cellulite. The consumption of medications can explain the worsening or triggering of some types of alopecia and is a frequent cause of telogen and anagen effluvium. We should rule out iron metabolism disorders – especially in childbearing-aged women – thyroid diseases, low-calorie and low-protein diets, pregnancy, menstrual disorders, neoplastic diseases, and chemotherapeutic treatments, among others.
Molecular mechanisms of ferroptosis and their role in inflammation
Published in International Reviews of Immunology, 2023
Feng Wang, Jingya He, Ruxiao Xing, Tong Sha, Bin Sun
In addition to the inflammation caused by infection, there is an established link between the inflammation caused by cell senescence and iron metabolism. One possible reason for iron accumulation is the age-related increase in tissue-resident senescent cells, which drive inflammation and cause various diseases associated with advanced age. The accumulation of iron renders aging tissues vulnerable to oxidative stress, which may lead to cell dysfunction and ferroptosis. It is worth noting that refers to the discrepancy in the ratio of iron to blood cells and elevated iron levels enhance the sensitivity of brain tissue to oxidative dysfunction (e.g., lower glutathione, increased ROS, and increased lipid peroxidation), and accelerate ferroptosis [31]. Iron metabolism disorders lead to oxidative stress and ferroptosis; conversely, they are involved in regulating the inflammatory response. Therefore, ferroptosis is also one of the bases for the development of inflammatory diseases.
Evaluating hematological parameters in women with endometriosis
Published in Journal of Obstetrics and Gynaecology, 2021
Ashraf Moini, Mahboobeh Ghanaat, Reihaneh Hosseini, Hadith Rastad, Ladan Hosseini
Our findings regarding the level of Hb was in line with some studies (Kim et al. 2014; Tokmak et al. 2016), that showed lower Hb concentrations in women with endometriosis. It is possible that severe endometriosis with low Hb levels is associated with RBC regulation or iron metabolism disorders (Defrère et al. 2011; González-Ramos et al. 2012; Kim et al. 2014). Results of the present study, contrary to previous studies, showed lower platelet count in the endometriosis group that was an unexpected finding since an increased number of platelets in response to chronic inflammation is quite expected (Aydın 2019). Also, it has been suggested that in endometriosis disease, platelets disturb the reaction and function of killer cells and play a role in the metaplasia of smooth muscles and fibrogenesis (Seckin et al. 2018). Nonetheless, it had low predictive power for the diagnosis of endometriosis. On the other hand, there is an inverse correlation between MPV and platelet count that may explain the low platelet count in this study.
Iron metabolism and chronic inflammation in IgA nephropathy
Published in Renal Failure, 2023
Zhang-yu Tian, Zhi Li, Ling Chu, Yan Liu, Jin-rong He, Yu Xin, Ai-mei Li, Hao Zhang
Iron is an indispensable element. Iron is regulated at the systemic level and the cellular level, mainly through the absorption, transport, distribution, storage, utilization and excretion of iron metabolic processes to maintain iron homeostasis in the human body [1]. Iron metabolism disorders are closely associated with a diversity of diseases, such as cancer, neurodegenerative diseases, ischemia–reperfusion injury, hematologic disorders, inflammatory bowel diseases, liver diseases, pulmonary fibrosis and chronic kidney disease (CKD) [2–9]. Additionally, the kidney influences the regulation of iron homeostasis [10–12], while imbalances in iron homeostasis can exacerbate kidney injury [11,13–15].