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Canine Malignant Hyperthermia/Canine Stress Syndrome
Published in S. Tsuyoshi Ohnishi, Tomoko Ohnishi, Malignant Hyperthermia, 1994
Susceptibility to MH in dogs has been demonstrated to be inherited in an autosomal dominant pattern.8 Gradations in susceptibility to halothane anesthesia, caffeine-induced contracture, and erythrocyte fragility have been observed.8,12,13,16
The development and application of a novel reagent for fixing red blood cells with glutaraldehyde and paraformaldehyde
Published in Hematology, 2023
Xinyang Li, Miyang Li, Yuhong Wang, Shengbao Duan, Hongmei Wang, Yong Li, Zhonghe Cai, Ruiyao Wang, Shuang Gao, Yan Qu, Tianxia Wang, Fei Cheng, Tiemei Liu
Figure 5 demonstrated that the concentration of free hemoglobin in the supernatant of type A /B red blood cell reagents was low during the first three months, whereas the concentration of free hemoglobin in the supernatant of untreated red blood cell reagents had increased significantly since the third month, while the concentration of red blood cell hemoglobin treated with 0.005% GA /0.05% PFA had not increased significantly. It demonstrated that untreated red blood cell reagents exhibit severe hemolysis after the third month. In the third month, the difference in hemoglobin content between untreated A-type red blood cell reagent and untreated B-type red blood cell reagent is primarily attributable to the fact that in three parallel experiments of untreated B-type red blood cells, the hemoglobin content in one experiment was lower, while the results in the other two experiments were higher, which was not significantly different from that of untreated A-type red blood cells (shown by the error bar in Figure 5). The low hemoglobin concentration in the supernatant of untreated type B red blood cells may be due to human operation error or variations in erythrocyte fragility between individuals. Specific values of free hemoglobin in supernatant can be found in Table S3 of the supplementary materials.
The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats
Published in Pharmaceutical Biology, 2022
Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist
The immunological and haematological effects of Dox were also demonstrated by our study. The suppression of red blood cells was observed in the Dox group, and may be caused by haemoglobin oxidation and an increase in erythrocyte fragility (Shinohara and Tanaka 1980; Oto et al. 2015; Sergazy et al. 2020). Importantly, PFPE feeding improved the levels of red blood cells, which may be due to the antioxidant properties of PFPE. This is in accordance with other studies that demonstrated the use of antioxidant substances, such as polyphenol, could protect this erythrocyte damage from Dox (Sergazy et al. 2020). Unexpectedly, while using Dox alone did not change platelet levels when compared to normal rats, the combination of Dox and PFPE increased the levels of the platelets. Although the mechanism of this scenario has not been fully elucidated, there is evidence showing some plant extract, Carica papaya L. (Caricaceae) leaf extracts, increased the number of platelets in animals and humans (Dharmarathna et al. 2013; Gadhwal et al. 2016). Interestingly, the analysis of chemical compounds found in C. papaya extract included alkaloids, tannins, anthraquinone, cardenolides, steroids, saponins, etc. (Dharmarathna et al. 2013), some of which related to compounds in PFPE.
Exercise and anemia in cancer patients: could it make the difference?
Published in Expert Review of Hematology, 2021
Alice Avancini, Lorenzo Belluomini, Daniela Tregnago, Ilaria Trestini, Michele Milella, Massimo Lanza, Sara Pilotto
Cancer-related anemia is typically diagnosed in patients with advanced disease stage, and it is primarily due to the secretion of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, and IL-6 [13]. In turn, inflammation may suppress the replication and maturation of erythroid precursors, limiting the responsiveness to erythropoietin (EPO), increasing the apoptosis of immature erythroblast, changing the iron metabolism, and inhibiting Hb synthesis [14,15]. More in-depth, some cytokines may alter the expression of hypoxia-inducible factor 1 (HIF-1), diminishing the EPO secretion, the hormone controlling the maturation, differentiation, and survival of erythrocytes by the kidney [13]. Moreover, factors such as IL-6 may stimulate hepcidin synthesis, which acts as an inhibitor of ferroportin, resulting in impaired iron metabolism [13]. Chronic inflammation is related to reactive oxygen species (ROS) production that may increase erythrocyte fragility. Finally, cancer-related anemia is frequently associated with other characteristics, such as weight loss, anorexia, and cachexia [13]. These features are linked with a poor nutritional status, such as deficiencies in vitamin B12, folic acid, and iron, essential for the maturation of red blood cells [14,15].