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Herbal Treatment for Irritable Bowel Syndrome
Published in Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders, 2023
Hasya Nazh Ekin, Didem Deliorman Orhan
IBS generally cannot be diagnosed with serum biomarkers or tests. Generally, the test results have been shown as normal. As a result of these handicaps, some criteria have been determined for the diagnosis of IBS. Nowadays, Rome criteria are used based on clinical studies on IBS symptoms in the United Kingdom. When the process of the regulation of these criteria is examined, it is seen that it was designed based on the Manning criteria prepared as a result of the studies carried out by Manning in 1978. At least two of six cardinal criteria (such as the looser stool of the starting of the pain, the mucus passage, relief of pain after intestinal movements, apparent distension, and lacking evacuation sensation, more frequent intestinal movements at the beginning of pain) should be seen in patients. After the Manning criteria were revised in 1990, the Rome criteria were published. Rome criteria are more restrictive than the Manning criteria.
The Modern Conceptualization of Unexplained Symptoms
Published in Peter Manu, The Psychopathology of Functional Somatic Syndromes, 2020
Compared with patients with organic disorders, those with irritable bowel syndrome reported a higher frequency of the following four symptoms: abdominal distention, as evidenced by appearance or tight clothing; relief of pain with bowel movement; more frequent stools with the onset of pain; and looser bowel movement with the onset of pain. A feeling of incomplete evacuation and passage of mucus were also common in the irritable bowel group. These six symptoms came to be known as the Manning criteria for the diagnosis of irritable bowel syndrome.
Chronic Abdominal Pain
Published in Kevin W. Olden, Handbook of Functional Gastrointestinal Disorders, 2020
The dilemma of diagnosis by exclusion yields evaluations that are perceived by both clinicians and patients as expensive and frustrating. Attempts at prospective diagnosis using physiological symptom patterns (similar to the Manning criteria for IBS) (4) have had limited success in chronic abdominal pain, largely due to their unfortunate reliance on biomedical symptom patterns.
Advancements in drug development for diarrhea-predominant irritable bowel syndrome
Published in Expert Opinion on Investigational Drugs, 2018
Giovanni Dothel, Maria Raffaella Barbaro, Emanuel Raschi, Giovanni Barbara, Fabrizio De Ponti
The irritable bowel syndrome (IBS) is a functional bowel disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits [1]. IBS has an estimated prevalence of 10–25% in the general population, although large variability exists in geographic regions due to the application of different diagnostic instruments (Manning criteria, Rome-I–IV criteria) [2,3]. IBS is associated with a marked socioeconomic burden due to its direct costs, such as hospitalization and medications and indirect expenses related mainly to reduced quality of life, increased work absenteeism [4].
Perinatal and familial risk factors for irritable bowel syndrome in a Swedish national cohort
Published in Scandinavian Journal of Gastroenterology, 2018
Rasmus Waehrens, Xinjun Li, Jan Sundquist, Kristina Sundquist, Bengt Zöller
An important strength of the present study was its ability to examine the association between perinatal risk factors and risk of IBS in young adulthood with the use of a nationwide birth cohort there all data were obtained from large nationwide registers. The results were adjusted for other perinatal risk factors as well as other broadly measured potential confounders. Bias that may potentially result from self-reporting was prevented with the use of registry-based data. The Swedish personal ID numbers (replaced by serial numbers) are a valuable tool for linking medical registers, and allow for almost 100% coverage of the Swedish healthcare system [26]. Study limitations include that only specialist treated cases of IBS in Sweden are included, and the diagnosis of IBS is thus more likely to be correct. However, the diagnosed individuals are likely to represent the most severely affected IBS patients. It is possible that other risk factors are more important in the less severe cases. However, previously we have found similar familial inheritance among specialist treated and primary health care–treated IBS patients [16]. The diagnostic criteria have changed over time, which is a limitation of the study [27,28]. Five different sets of diagnostic criteria for IBS have been used: the Manning criteria 1978 [27], the Rome I criteria (1994), the Rome II criteria (1999–2000), the Rome III criteria (2006) and the Rome IV criteria (2016) [28]. The diagnostic criteria may affect the incidence and prevalence of IBS [29,30]. Manning criteria usually gives higher prevalence than Rome criteria [29,30]. Rome positive IBS patients have been suggested to form a subgroup of Manning positive IBS patients with more severe abdominal symptoms, more psychopathology, and more frequent use of the health care system [30]. The follow up time in the present study (1991–2010) was mainly during the period when the Rome criteria were used, which is a strength of the present study using the stricter Rome criteria. Moreover, the Swedish Patient register has been validated for IBS [31]. IBS diagnosis was judged to be correct in 70% of cases. In further 9.6% of cases, IBS was a probable diagnosis. Thus, in totally, 79.6% IBS cases were correct or a probable diagnosis. Moreover, only 5% of cases had an obvious incorrect IBS diagnosis [31].