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Inflammatory Disorders of the Nervous System
Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020
Lathyrism: endemic in parts of South Asia, and presents as a subacute or chronic spastic paraparesis in people who regularly ingest chickling pea vetch over several months. It is thought to be caused by a toxin in the chickling pea.
Animal Models of Scoliosis
Published in Yuehuei H. An, Richard J. Friedman, Animal Models in Orthopaedic Research, 2020
Noriaki Kawakami, Masao Deguchi, Tokumi Kanemura
Experimental diets containing Lathyrus odoratus induced scoliosis.3,52,53 Geiger et al.52 investigated the effect of feeding lathyrus peas and succeeded in inducing lathyrism in young and adult rats. He noticed growth retardation of young animals with other symptoms, such as lameness, spinal curvature, sternal curvature, etc. Autopsy showed extreme curvature that was mostly ventral in the thoracic region. Ponseti53 studied characteristics of scoliosis induced by lathyrism in rats to explore the pathogenesis of scoliosis and reported hitherto unrecognized lesions in the epiphyseal plates. Yamamoto2 fed bipedal rats on modified Steenbock's diet that included Lathyrus odoratus to analyze the influence of the upright position on the development of scoliotic deformity due to dietary feedings. He compared them with rachitic quadrupedal, control bipedal, and control quadrupedal rats, and reported that marked scoliosis developed only in rachitic bipedal rats. This result indicated that the upright position played an important role to produce marked scoliosis even in rachitic rats. Compared with the relatively large amount of Lathyrus odoratus that was needed to produce scoliosis, feeding a small amount of B-aminopropionitrile (BAPN) has also been proved to produce scoliosis and other skeletal deformities by Lalich and Angevine.54
Experimental Stomatology
Published in Samuel Dreizen, Barnet M. Levy, Handbook of Experimental Stomatology, 2020
Samuel Dreizen, Barnet M. Levy
Krikos et al.149 described the oral changes in experimental lathyrism in rats. Diets containing sweet pea seeds (Lathyrus odoratus) produce a disease in this rodent that primarily affects the connective tissues. The culpable chemical is β-aminoproprionitrile, a two-carbon compound with an amino group on one end and a nitrile group on the other.
Prolonged consumption of grass pea (64 g/Cu/day) along with millets and other cereals causes no neurolathyrism
Published in Nutritional Neuroscience, 2021
R. Hari Kumar, Arjun Khandare, A. Laxmaiah, I. Meshram, N. Arlappa, Vakdevi Validandi, K. Venkaiah, P. Amrutha Rao, P. V. Sunu, V. Bhaskar, G. S. Toteja
A pre-tested screening questionnaire was administered by the trained field staff at the HH level. The population were screened for the signs and symptoms of lathyrism along with morbidity such as hypertension, type 2 diabetes, stroke and bone fractures.